Drug & supplement interaction

Corkwood Tree + Defibrotide Sodium

Defibrotide Sodium brand name: Defitelio.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Corkwood Tree and Defibrotide Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Corkwood Tree and Defibrotide Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Defibrotide Sodium and Corkwood Tree in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Corkwood Tree safety at a glance

Corkwood Tree overall Avoid The plant contains potent toxic tropane alkaloids and is not safe for self-use.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Defibrotide Sodium and Corkwood Tree? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Defibrotide Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Defibrotide Sodium is filed under a single classification — anticoagulant/antiplatelet drugs. Corkwood Tree has documented interactions with 1 drug class — the most serious being anticholinergic drugs (moderate) — and none of Defibrotide Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Corkwood Tree Does Interact With Other Medications

Corkwood Tree has 195 moderate known drug interactions in our database — Defibrotide Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 195 No known interaction 2,635 (incl. Defibrotide Sodium)
Taking anything else?

Check Another of Your Medications Against Corkwood Tree

Covers the 2,830 medications we’ve checked against Corkwood Tree. Pick one to open its full report.

What to actually watch for

What Corkwood Tree Itself Has Been Linked To

This is not an interaction — nothing below involves Defibrotide Sodium. It is the side-effect record for Corkwood Tree on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Corkwood Tree, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Trouble passing urine Worth acting on Additional detail

    “Orally, corkwood tree leaves can cause urinary retention. Alkaloid constituents in corkwood tree, namely scopolamine and atropine, have anticholinergic effects, which explains reports of urinary retention associated with corkwood tree leaf use.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in urinary retention.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.
  • Hallucinations / Confusion Worth acting on Additional detail

    “Orally, corkwood tree leaves can cause agitation, delirium, and hallucinations. In one case, a 22-year-old male presented with agitation, delirium, and visual hallucinations, among other symptoms, after ingesting 5-10 corkwood tree leaves. Alkaloid constituents in corkwood tree, namely scopolamine and atropine, have anticholinergic effects, which likely explains these adverse psychiatric effects.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in delirium.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.
  • Raised blood pressure Worth acting on Additional detail

    “Orally, corkwood tree leaves can cause hypertension and tachycardia. In one case, a 22-year-old male presented with hypertension and tachycardia, among other symptoms, after ingesting 5-10 corkwood tree leaves. Alkaloid constituents in corkwood tree, namely scopolamine and atropine, have anticholinergic effects, which likely explains these adverse cardiovascular effects.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.
  • Flushing Additional detail

    “Orally, corkwood tree leaves can cause flushing, hyperthermia, and anhidrosis. In one case, a 22-year-old male presented with flushing and hyperthermia, among other symptoms, after ingesting 5-10 corkwood tree leaves. Anhidrosis, or the inability to sweat normally, has also been observed with corkwood tree leaf use.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in niacin-induced flushing.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.
  • Dry mouth Additional detail

    “Orally, corkwood tree leaves can cause dry mouth. In one case, a 22-year-old male presented with dry mouth, among other symptoms, after ingesting 5-10 corkwood tree leaves. Alkaloid constituents in corkwood tree, namely scopolamine and atropine, have anticholinergic effects, which likely explains the dry mouth reported in this case.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in dry mouth.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.
  • A fast or pounding heartbeat Additional detail

    Recorded for Corkwood Tree in the same Natural Medicines adverse-effect record shown under Hallucinations / Confusion above.

  • Anxiety or restlessness Additional detail

    Recorded for Corkwood Tree in the same Natural Medicines adverse-effect record shown under Hallucinations / Confusion above.

Everything above comes from the Natural Medicines adverse-effect record for Corkwood Tree — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Defibrotide Sodium’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Defibrotide Sodium column appears here.

Special populations

Corkwood Tree in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Defibrotide Sodium

This page covers Corkwood Tree only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Defibrotide Sodium page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Defibrotide Sodium page

“Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Defibrotide Sodium interaction page

How much people look this up

Where Corkwood Tree and Defibrotide Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corkwood Tree
Steady interest

#1,106 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Defibrotide Sodium
Top half

#1,132 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Corkwood Tree reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Corkwood Tree and Defibrotide Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Corkwood Tree

What is Corkwood Tree?

  • Source of scopolamine and hyoscyamine alkaloids
  • Traditional use as a stimulant or for fatigue
  • Historic use for motion sickness (via its alkaloids)
  • Antispasmodic / smooth muscle effects

Corkwood Tree (Duboisia myoporoides) is an Australian plant best known as a commercial source of powerful tropane alkaloids like scopolamine and hyoscyamine, not as a safe home remedy. The raw plant is highly toxic and should not be used as a dietary supplement; only purified, medically prescribed alkaloids derived from it should be used, and only under a doctor's care.

Duboisia myoporoides · Solanaceae · Leaves · Not commonly sold as a consumer supplement; historically a source of plant extracts and isolated alkaloids

An interaction check asks whether these two react with each other — it does not ask whether Corkwood Tree is a good idea for someone in your situation. Here is what our Corkwood Tree record says about it on its own.

Corkwood Tree: dosing

There is no safe established dose of Corkwood Tree leaf for self-use, and it should not be taken as a supplement. The only appropriate use of compounds from this plant is in standardized, prescription medicines (such as scopolamine or hyoscyamine) that are dosed and monitored by healthcare professionals.If you have been given a medicine derived from this plant, follow the product label and your prescriber's directions exactly. Do not attempt to make or use any homemade preparation.

From our Corkwood Tree monograph — the full record covers uses, side effects and every documented interaction.

Read the full Corkwood Tree monograph & all interactions
Medication

About Defibrotide Injection

What Is Defibrotide Injection Used For?

Brand name: Defitelio

Defitelio (defibrotide injection) is used to treat hepatic veno-occlusive disease (VOD) — also called sinusoidal obstruction syndrome (SOS) — in adult and pediatric patients. This is a serious condition where small blood vessels in the liver become blocked, most often after a hematopoietic stem-cell transplant (HSCT).

Defitelio is specifically indicated when VOD is accompanied by kidney dysfunction or pulmonary (lung) dysfunction, making it a treatment for one of the most severe forms of this complication.

Most-Reported Side Effects for Defibrotide Sodium

From FAERS, the FDA’s public side-effect reporting system (3,546 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Venoocclusive disease 564 reports
Multiple organ dysfunction syndrome 343 reports
Venoocclusive liver disease 336 reports
Hypotension 159 reports
Hemorrhage 155 reports
See full Defibrotide Injection drug information
Keep checking

Other Drugs & Corkwood Tree

Browse every other medication we’ve checked against Corkwood Tree — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
195Moderate
0Minor
2,634No known interaction
195 Moderate 2,634 No interaction
Moderate

195 interactions

Showing 60 of 195 moderate interactions — see all 195 on the Corkwood Tree page.

No interaction 2,634 drugs checked — show the list

We also checked Corkwood Tree against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,634 medications checked with no known interaction — see the full Corkwood Tree list.

See the full Corkwood Tree interactions page
See every supplement checked against Defibrotide Sodium, ranked by severity
Evidence & sources

Corkwood Tree References

The 2 references that drive our Corkwood Tree monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Corkwood Tree and Defibrotide Sodium Together: Common Questions

Is it safe to take Corkwood Tree with Defibrotide Sodium?
We do not list a known interaction between Corkwood Tree and Defibrotide Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Corkwood Tree and Defibrotide Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Defibrotide Sodium is filed under 1 classification, and Corkwood Tree has documented interactions with 1 drug class — none of Defibrotide Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Corkwood Tree interact with any other medications?
Yes. Corkwood Tree has 195 documented drug interactions in our database — Defibrotide Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Defibrotide Sodium interact with any supplements?
Yes. Defibrotide Sodium has documented interactions with 202 supplements in our database — Corkwood Tree is not one of them. The Defibrotide Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Corkwood Tree monograph Uses, safety profile, and every drug interaction in one place Defibrotide Injection drug information The full plain-English guide to this medication Defibrotide Sodium supplement interactions Every supplement checked against Defibrotide Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.