Drug & supplement interaction

Slimfast Diet + Defibrotide Sodium

Defibrotide Sodium brand name: Defitelio.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Slimfast Diet and Defibrotide Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Slimfast Diet and Defibrotide Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Defibrotide Sodium and Slimfast Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Slimfast Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Slimfast Diet at all — not against Defibrotide Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Slimfast Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Slimfast Diet safety at a glance

Slimfast Diet overall Use caution Generally well tolerated for healthy adults, but it is a food-based plan rather than a tested medicine and is not right for everyone.
Pregnancy Use caution Calorie-restricting diet plans are not recommended during pregnancy; speak with your doctor about nutrition needs.
Breastfeeding Use caution Restricting calories while breastfeeding may not be appropriate; check with your doctor before using a meal-replacement plan.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Defibrotide Sodium and Slimfast Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Defibrotide Sodium’s Own FDA Label Lists

This is not an interaction — none of it involves Slimfast Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Defibrotide Sodium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Slimfast Diet and take the medicine. 4 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on
  • Bleeding or bruising Worth acting on mentioned in 4.4% of FDA reports for Defibrotide Sodium
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Low blood pressure mentioned in 4.5% of FDA reports for Defibrotide Sodium
  • Diarrhea
  • Vomiting
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Defibrotide Sodium. Read the label on DailyMed › Where a percentage is shown, it is the share of 3,546 voluntary FDA FAERS reports for Defibrotide Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Slimfast Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Slimfast Diet side to compare — that is a limit of the record, not a statement that Slimfast Diet has no side effects.

Everything else you take

See Every Supplement That Interacts With Defibrotide Sodium

This page covers Slimfast Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Defibrotide Sodium page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Defibrotide Sodium page

“Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Defibrotide Sodium interaction page

How much people look this up

Where Slimfast Diet and Defibrotide Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Slimfast Diet
Steady interest

#948 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Defibrotide Sodium
Top half

#1,312 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Slimfast Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Slimfast Diet and Defibrotide Sodium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Slimfast Diet

What is Slimfast Diet?

  • Weight loss
  • Weight maintenance
  • Meal replacement
  • Calorie control
  • Convenient on-the-go nutrition

SlimFast is a commercial brand of meal-replacement shakes, bars, and snacks designed to help with weight loss by controlling daily calories. It is not an herb or single supplement, and while structured meal-replacement plans can help some people lose weight in the short term, long-term success depends on overall diet and lifestyle. Talk with your doctor or pharmacist before starting if you have a medical condition such as diabetes.

Not applicable (commercial meal-replacement product, not a plant) · Ready-to-drink shakes, shake powders, meal-replacement bars, and snack products

An interaction check asks whether these two react with each other — it does not ask whether Slimfast Diet is a good idea for someone in your situation. Here is what our Slimfast Diet record says about it on its own.

Slimfast Diet: dosing

There is no medicinal "dose" for SlimFast because it is a food product. Instead, follow the plan and serving sizes printed on the product label. A common approach is replacing one or two meals a day with a SlimFast shake or bar, eating one balanced meal, and having a small snack or two.Drink plenty of water and aim to keep your overall diet balanced.

From our Slimfast Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Slimfast Diet monograph & all interactions
Medication

About Defibrotide Injection

What Is Defibrotide Injection Used For?

Brand name: Defitelio

Defitelio (defibrotide injection) is used to treat hepatic veno-occlusive disease (VOD) — also called sinusoidal obstruction syndrome (SOS) — in adult and pediatric patients. This is a serious condition where small blood vessels in the liver become blocked, most often after a hematopoietic stem-cell transplant (HSCT).

Defitelio is specifically indicated when VOD is accompanied by kidney dysfunction or pulmonary (lung) dysfunction, making it a treatment for one of the most severe forms of this complication.

Most-Reported Side Effects for Defibrotide Sodium

From FAERS, the FDA’s public side-effect reporting system (3,546 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Venoocclusive disease 564 reports
Multiple organ dysfunction syndrome 343 reports
Venoocclusive liver disease 336 reports
Hypotension 159 reports
Hemorrhage 155 reports
See full Defibrotide Injection drug information
Keep checking

Other Drugs & Slimfast Diet

Browse every other medication we’ve checked against Slimfast Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Slimfast Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Slimfast Diet list.

See the full Slimfast Diet interactions page
See every supplement checked against Defibrotide Sodium, ranked by severity
Evidence & sources

Slimfast Diet References

The 6 references that drive our Slimfast Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pritchett AM, Deswal A, Aguilar D, et al. Lifestyle Modification with Diet and Exercise in Obese Patients with Heart Failure - A Pilot Study. J Obes Weight Loss Ther. 2012 Mar 1;2(2):1-8. PubMed
  2. Berkowitz RI, Wadden TA, Gehrman CA, et al. Meal replacements in the treatment of adolescent obesity: a randomized controlled trial. Obesity (Silver Spring). 2011 Jun;19(6):1193-9. PubMed
  3. Morgan LM, Griffin BA, Millward DJ, et al. Comparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors. Public Health Nutr. 2009 Jun;12(6):799-807. PubMed
  4. Truby H, Baic S, deLooy A, et al. Randomised controlled trial of four commercial weight loss programmes in the UK: initial findings from the BBC "diet trials." BMJ. 2006 Jun 3;332(7553):1309-14. PubMed
  5. Noakes M, Foster PR, Keogh JB, Clifton PM. Meal replacements are as effective as structured weight-loss diets for treating obesity in adults with features of metabolic syndrome. J Nutr. 2004 Aug;134(8):1894-9. PubMed
  6. Yip I, Go VL, DeShields S, et al. Liquid meal replacements and glycemic control in obese type 2 diabetes patients. Obes Res. 2001 Nov;9 Suppl 4:341S-347S. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Slimfast Diet While Taking Defibrotide Sodium: Common Questions

Is it safe to follow Slimfast Diet while taking Defibrotide Sodium?
We do not list a known interaction between Slimfast Diet and Defibrotide Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Defibrotide Sodium interact with any supplements?
Yes. Defibrotide Sodium has documented interactions with 202 supplements in our database — Slimfast Diet is not one of them. The Defibrotide Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Slimfast Diet monograph Uses, safety profile, and every drug interaction in one place Defibrotide Injection drug information The full plain-English guide to this medication Defibrotide Sodium supplement interactions Every supplement checked against Defibrotide Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Defibrotide Sodium and Slimfast Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.