Drug & supplement interaction

Purple Nut Sedge + Defibrotide Sodium

Defibrotide Sodium brand name: Defitelio.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Purple Nut Sedge has a moderate interaction with Defibrotide Sodium. In vitro, purple nut sedge inhibits platelet aggregation.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Purple Nut Sedge and Defibrotide Sodium

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Defibrotide Sodium

Defibrotide Sodium falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Purple Nut Sedge interacts with.

In vitro, purple nut sedge inhibits platelet aggregation. Theoretically, purple nut sedge might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: defibrotide is a strong clot-fighting medicine given in the hospital to people recovering from a stem-cell transplant. In lab dishes, purple nut sedge has been shown to make platelets (the cells that help blood clot) a little less sticky. So in theory, adding it on top of defibrotide could nudge your bleeding risk a bit higher, with things like easy bruising, nosebleeds, or bleeding that's harder to stop.

That said, this is only test-tube evidence, not proven in people, so I wouldn't panic. Honestly, if you're on defibrotide you're already in close hospital care, and you shouldn't add any new supplement without your transplant team's okay. Please run purple nut sedge by your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Seo EJ, Lee DU, Kwak JH, et al. Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone. J Ethnopharmacol. 2011;135(1):48-54. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Purple Nut Sedge Also Interacts With Other Medications

Purple Nut Sedge has 423 moderate known drug interactions in our database — the Defibrotide Sodium one above is one of them. If you take anything else, check it against the full list below.

Moderate 423 No known interaction 2,407 (incl. Defibrotide Sodium)
Taking anything else?

Check Another of Your Medications Against Purple Nut Sedge

Covers the 2,830 medications we’ve checked against Purple Nut Sedge. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Defibrotide Sodium

This page covers Purple Nut Sedge only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Defibrotide Sodium page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Defibrotide Sodium page

“Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Defibrotide Sodium interaction page

How much people look this up

Where Purple Nut Sedge and Defibrotide Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Purple Nut Sedge
Top half

#718 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Defibrotide Sodium
Top half

#1,027 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Purple Nut Sedge

What is Purple Nut Sedge?

  • Digestive upset and bloating
  • Menstrual cramps and irregular periods
  • Fever and inflammation
  • Skin and weight-related concerns
  • Antimicrobial uses

Purple nut sedge (Cyperus rotundus) is a common weed whose tubers have a long history in Ayurvedic, Chinese, and other traditional medicine systems, mostly for digestive and menstrual complaints. Modern human evidence is very limited, so its benefits remain unproven. If you want to try it, talk with a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Read the full Purple Nut Sedge monograph & all interactions
Medication

About Defibrotide Injection

What Is Defibrotide Injection Used For?

Brand name: Defitelio

Defitelio (defibrotide injection) is used to treat hepatic veno-occlusive disease (VOD) — also called sinusoidal obstruction syndrome (SOS) — in adult and pediatric patients. This is a serious condition where small blood vessels in the liver become blocked, most often after a hematopoietic stem-cell transplant (HSCT).

Defitelio is specifically indicated when VOD is accompanied by kidney dysfunction or pulmonary (lung) dysfunction, making it a treatment for one of the most severe forms of this complication.

See full Defibrotide Injection drug information
Keep checking

Other Drugs & Purple Nut Sedge

Browse every other medication we’ve checked against Purple Nut Sedge — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
423Moderate
0Minor
2,406No known interaction
423 Moderate 2,406 No interaction
Moderate

423 interactions

Showing 60 of 423 moderate interactions — see all 423 on the Purple Nut Sedge page.

No interaction 2,406 drugs checked — show the list

We also checked Purple Nut Sedge against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,406 medications checked with no known interaction — see the full Purple Nut Sedge list.

See the full Purple Nut Sedge interactions page
See every supplement checked against Defibrotide Sodium, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Purple Nut Sedge monograph › Uses, safety, and every drug interaction in one place Defibrotide Sodium supplement interactions › Every supplement checked against Defibrotide Sodium, ranked by severity Defibrotide Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Purple Nut Sedge and Defibrotide Sodium Together: Common Questions

Can you take Purple Nut Sedge with Defibrotide Sodium?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Purple Nut Sedge and Defibrotide Sodium interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.