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Dietary supplement

Willow Bark and Herb 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Willow Bark and Herb 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Willow Bark and Herb 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Willow Bark and Herb 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for low back pain, osteoarthritis joint pain, headache.Based on those ingredients, 127 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are White Willow. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Willow Bark and Herb 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Willow Bark and Herb 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Willow Bark and Herb 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: white willow bark at 450 mg per capsule. Willow bark is an herbal remedy traditionally used for pain and inflammation; it works because it contains salicin, a compound your body converts to a salicylate that works similarly to aspirin.

The capsule also contains gelatin and water as inactive ingredients to hold and deliver the willow bark.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Willow Bark's overall clinical evidence instead.

Moderate

Some clinical evidence supports Willow Bark for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Back pain — rated "Possibly Effective" (Natural Medicines).

Willow bark is possibly effective for back pain based on the evidence we hold. For headaches, colds, and flu, the evidence isn't established—we don't have enough reliable data to know whether it helps.

If you're considering this for back pain, talk with your pharmacist or doctor about how it compares to other options.

The evidence, ingredient by ingredient Willow Bark

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Willow bark is generally well tolerated short-term in healthy adults, but because it acts like aspirin, it's not right for everyone. The most common side effects are diarrhea, heartburn, indigestion, and vomiting.

Some people get itching or a rash, and in rare cases, it can cause gastrointestinal bleeding or affect kidney function. People allergic to aspirin may have serious reactions, including anaphylaxis or swelling of the eyes.

Avoid willow bark during pregnancy—its aspirin-like action poses risks, especially later in pregnancy. There isn't enough safety information for breastfeeding, so it's best to skip it while nursing.

Side effects, ingredient by ingredient Willow Bark

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Willow Bark.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 127 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before adding this product if you take blood thinners or antiplatelet drugs (Moderate-severity interaction), aspirin or aspirin-like pain relievers (Moderate), or acetazolamide (Moderate). Because willow bark acts like aspirin, any medication that interacts with aspirin could be a concern—the search tool on this page can check your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Willow bark may help with back pain if other options don't work for you. But because it acts like aspirin, it's not for anyone on blood thinners, aspirin, or certain other medications.

Talk with your pharmacist before starting, especially if you take any regular prescriptions or have a history of stomach problems or aspirin sensitivity.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Willow Bark and Herb 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435108106
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 285896
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Willow Bark and Herb 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064435108106
IngredientAmount% DV
White Willow450 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2004 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Willow Bark and Herb 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Willow Bark and Herb 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Willow Bark and Herb 450 mg by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

White Willow

Interacts with
127 drugs
450 mg per serving Form: White Willow, White Willow

Willow bark is a traditional plant remedy that contains salicin, a compound related to aspirin, and is most often used for pain and inflammation. Some...

White Willow monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Willow Bark and Herb 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Willow Bark and Herb 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
127Drugs
127 Moderate

Ingredients driving the most interactions

White Willow 127

Individual Drug Interactions

The ingredients in Willow Bark and Herb 450 mg interact with 127 drugs. Click any drug to see the details.

1 of the 1 ingredient in Willow Bark and Herb 450 mg interact with drugs. Each result below shows which ingredient is responsible. White Willow

Each ingredient & the kinds of drugs it affects

For each ingredient in Willow Bark and Herb 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

White Willow5 drug types · 127 drugs

Acetazolamide

Theoretically, willow bark might result in additive adverse effects associated with acetazolamide.
Willow bark contains salicin, a plant salicylate. Human case reports suggests that a combination of acetazolamide and salicylate increases unbound plasma levels of acetazolamide, as well as adverse effects related to acetazolamide.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Willow bark has antiplatelet effects, but less so than aspirin.

Likelihood Probable Evidence D
Aspirin

Theoretically, willow bark might increase the effects and adverse effects of aspirin.
Willow bark contains salicin, a plant salicylate. It might have an additive effect when taken with other salicylate-containing drugs such as aspirin.

Likelihood Probable Evidence D
Choline Magnesium Trisalicylate (Trilisate)

Theoretically, willow bark might increase the effects and adverse effects of choline magnesium trisalicylate.
Willow bark contains salicin, a plant salicylate. It might have an additive effect when taken with other salicylate-containing drugs such as choline magnesium trisalicylate.

Likelihood Probable Evidence D
Salsalate (Disalcid)

Theoretically, willow bark might increase the effects and adverse effects of salsalate.
Willow bark contains salicin, a plant salicylate. It might have an additive effect when taken with other salicylate-containing drugs such as salsalate.

Likelihood Probable Evidence D
White Willow full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Willow Bark and Herb 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Willow Bark and Herb 450 mg by TerraVita Premium Collection: Common Questions

Does Willow Bark and Herb 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Willow Bark and Herb 450 mg has a known interaction with 127 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Willow Bark and Herb 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my back pain?
Willow bark is possibly effective for back pain according to our data, so it may help. But it works like aspirin, so it's not for everyone—talk with your pharmacist to make sure it fits your situation.
Can I take this with my blood thinner or aspirin?
No. Willow bark has mild blood-thinning effects itself, so mixing it with blood thinners or aspirin increases bleeding risk. Always check with your pharmacist before adding it to any other medications.
What side effects might I get?
Most common are diarrhea, heartburn, indigestion, and vomiting. Some people get itching or a rash. Serious side effects like gastrointestinal bleeding or kidney problems are rare, and severe allergic reactions can happen in people who are allergic to aspirin.
Is this safe during pregnancy or breastfeeding?
No. Avoid willow bark during pregnancy because its aspirin-like action poses risks, especially later in pregnancy. There isn't enough safety data for breastfeeding, so skip it while nursing.
Is there anything else in this capsule besides willow bark?
The capsule contains gelatin and water as inactive ingredients to deliver the willow bark—nothing else.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Willow Bark and Herb 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Willow Bark and Herb 450 mg label
Go deeper

The Full Monographs Behind Willow Bark and Herb 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Willow Bark

Interacts with 127 drugs

Willow bark is a traditional plant remedy that contains salicin, a compound related to aspirin, and is most often used for pain and inflammation. Some evidence suggests it may modestly help...

Read the full Willow Bark monograph →
Sources

Sources & How We Checked

Willow Bark and Herb 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Willow Bark 12 references
  1. Chrubasik S, Eisenberg E, Balan E, et al. Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study. Am J Med 2000;109:9-14. PubMed
  2. Schmid B, Ludtke R, Selbmann HK, et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother Res 2001;15:344-50. PubMed
  3. Biegert C, Wagner I, Ludtke R, et al. Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials. J Rheumatol 2004;31:2121-30.
  4. Unsworth J, d'Assis-Fonseca A, Beswick DT, Blake DR. Serum salicylate levels in a breast fed infant. Ann Rheum Dis 1987;46:638-9. PubMed
  5. Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolic acidosis caused by salicylate. Clin Pediatr (Phila) 1981;20:53-4. PubMed
  6. Chrubasik S, Kunzel O, Model A, et al. Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology (Oxford) 2001;40:1388-93. PubMed
  7. Schmid B, Kotter I, Heide L. Pharmacokinetics of salicin after oral administration of a standardised willow bark extract. Eur J Clin Pharmacol. 2001;57:387-91. PubMed
  8. Krivoy N, Pavlotzky E, Chrubasik S, et al. Effect of salicis cortex extract on human platelet aggregation. Planta Med 2001;67:209-12. PubMed
  9. Mills SY, Jacoby RK, Chacksfield M, Willoughby M. Effect of a proprietary herbal medicine on the relief of chronic arthritic pain: a double-blind study. Br J Rheumatol 1996;35:874-8. PubMed
  10. Chrubasik, S., Kunzel, O., Black, A., Conradt, C., and Kerschbaumer, F. Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study. Phytomedicine 2001;8(4):241-251. PubMed
  11. <p>Moro PA, Flacco V, Cassetti F, Clementi V, Colombo ML, Chiesa GM, Menniti-Ippolito F, Raschetti R, Santuccio C. Hypovolemic shock due to severe gastrointestinal bleeding in a child taking an herbal syrup. Ann Ist Super Sanita. 2011;47(3):278-83.</p>
  12. Sweeney, K. R., Chapron, D. J., Brandt, J. L., Gomolin, I. H., Feig, P. U., and Kramer, P. A. Toxic interaction between acetazolamide and salicylate: case reports and a pharmacokinetic explanation. Clin Pharmacol Ther 1986;40(5):518-524.

See these in context on the Willow Bark monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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