Drug & supplement interaction

Burr Marigold + Defibrotide Sodium

Defibrotide Sodium brand name: Defitelio.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Burr Marigold and Defibrotide Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Burr Marigold and Defibrotide Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Defibrotide Sodium and Burr Marigold in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Burr Marigold at all — not against Defibrotide Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Burr Marigold safety at a glance

Burr Marigold overall Use caution Limited human safety data, so use cautiously and discuss with a healthcare professional first.
Pregnancy Avoid Not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Defibrotide Sodium and Burr Marigold? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Defibrotide Sodium’s Own FDA Label Lists

This is not an interaction — none of it involves Burr Marigold. These are the most notable effects listed in the ADVERSE REACTIONS section of Defibrotide Sodium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on
  • Bleeding or bruising Worth acting on mentioned in 4.4% of FDA reports for Defibrotide Sodium
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Low blood pressure mentioned in 4.5% of FDA reports for Defibrotide Sodium
  • Diarrhea
  • Vomiting
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Defibrotide Sodium. Read the label on DailyMed › Where a percentage is shown, it is the share of 3,546 voluntary FDA FAERS reports for Defibrotide Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Burr Marigold’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Burr Marigold side to compare — that is a limit of the record, not a statement that Burr Marigold has no side effects.

Everything else you take

See Every Supplement That Interacts With Defibrotide Sodium

This page covers Burr Marigold only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Defibrotide Sodium page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Defibrotide Sodium page

“Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Defibrotide Sodium interaction page

How much people look this up

Where Burr Marigold and Defibrotide Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Burr Marigold
Steady interest

#1,413 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Defibrotide Sodium
Top half

#1,094 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Burr Marigold is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Burr Marigold reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Burr Marigold and Defibrotide Sodium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Burr Marigold

What is Burr Marigold?

Burr Marigold
  • Minor wounds and skin irritation
  • Mild urinary complaints
  • Digestive upset
  • Coughs and colds
  • General 'cleansing' or diuretic effect

Burr Marigold (Bidens tripartita) is a wetland plant used in traditional medicine for wounds, urinary complaints, and digestive issues, but high-quality human research is lacking. Because its effectiveness and safety have not been well studied, it should be used cautiously, and avoided in pregnancy, breastfeeding, and in young children. Talk to a pharmacist or doctor before trying it.

Bidens tripartita · Asteraceae · Above-ground parts (herb), including leaves, stems, and flowering tops · Tea (dried herb infusion), tincture, liquid extract, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Burr Marigold is a good idea for someone in your situation. Here is what our Burr Marigold record says about it on its own.

Burr Marigold: dosing

There is no established standard dose for Burr Marigold. Traditional use has involved teas made from the dried herb, as well as tinctures and liquid extracts, but reliable dosing guidelines from clinical research do not exist.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Burr Marigold monograph — the full record covers uses, side effects and every documented interaction.

Read the full Burr Marigold monograph & all interactions
Medication

About Defibrotide Injection

What Is Defibrotide Injection Used For?

Brand name: Defitelio

Defitelio (defibrotide injection) is used to treat hepatic veno-occlusive disease (VOD) — also called sinusoidal obstruction syndrome (SOS) — in adult and pediatric patients. This is a serious condition where small blood vessels in the liver become blocked, most often after a hematopoietic stem-cell transplant (HSCT).

Defitelio is specifically indicated when VOD is accompanied by kidney dysfunction or pulmonary (lung) dysfunction, making it a treatment for one of the most severe forms of this complication.

Most-Reported Side Effects for Defibrotide Sodium

From FAERS, the FDA’s public side-effect reporting system (3,546 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Venoocclusive disease 564 reports
Multiple organ dysfunction syndrome 343 reports
Venoocclusive liver disease 336 reports
Hypotension 159 reports
Hemorrhage 155 reports
See full Defibrotide Injection drug information
Keep checking

Other Drugs & Burr Marigold

Browse every other medication we’ve checked against Burr Marigold — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Burr Marigold against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Burr Marigold list.

See the full Burr Marigold interactions page
See every supplement checked against Defibrotide Sodium, ranked by severity
Evidence & sources

Burr Marigold References

The 2 sources that drive our Burr Marigold monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Burr Marigold is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. MedlinePlus: Herbal Medicine — MedlinePlus (NIH) Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Burr Marigold and Defibrotide Sodium Together: Common Questions

Is it safe to take Burr Marigold with Defibrotide Sodium?
We do not list a known interaction between Burr Marigold and Defibrotide Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Defibrotide Sodium interact with any supplements?
Yes. Defibrotide Sodium has documented interactions with 202 supplements in our database — Burr Marigold is not one of them. The Defibrotide Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Burr Marigold monograph Uses, safety profile, and every drug interaction in one place Defibrotide Injection drug information The full plain-English guide to this medication Defibrotide Sodium supplement interactions Every supplement checked against Defibrotide Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Defibrotide Sodium and Burr Marigold?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.