Drug & supplement interaction

Sonoma Diet + Defibrotide Sodium

Defibrotide Sodium brand name: Defitelio.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sonoma Diet and Defibrotide Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone interested in this? Share
Facebook Post Reddit Email
On this page
Interaction report

Sonoma Diet and Defibrotide Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Defibrotide Sodium and Sonoma Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Sonoma Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Sonoma Diet at all — not against Defibrotide Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Sonoma Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sonoma Diet safety at a glance

Sonoma Diet overall Generally safe As a balanced whole-foods eating plan it is generally safe for most healthy adults.
Pregnancy Use caution Healthy eating is encouraged, but pregnant people have special nutrient needs and should consult their provider before following any structured diet.
Breastfeeding Use caution Nursing parents need extra calories and nutrients, so review any diet plan with a healthcare provider first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Defibrotide Sodium and Sonoma Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Defibrotide Sodium’s Own FDA Label Lists

This is not an interaction — none of it involves Sonoma Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Defibrotide Sodium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Sonoma Diet and take the medicine. 4 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on
  • Bleeding or bruising Worth acting on mentioned in 4.4% of FDA reports for Defibrotide Sodium
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Low blood pressure mentioned in 4.5% of FDA reports for Defibrotide Sodium
  • Diarrhea
  • Vomiting
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Defibrotide Sodium. Read the label on DailyMed › Where a percentage is shown, it is the share of 3,546 voluntary FDA FAERS reports for Defibrotide Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Sonoma Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Sonoma Diet side to compare — that is a limit of the record, not a statement that Sonoma Diet has no side effects.

Everything else you take

See Every Supplement That Interacts With Defibrotide Sodium

This page covers Sonoma Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Defibrotide Sodium page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Defibrotide Sodium page

“Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Defibrotide Sodium interaction page

How much people look this up

Where Sonoma Diet and Defibrotide Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sonoma Diet
Steady interest

#885 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Defibrotide Sodium
Top half

#1,094 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Sonoma Diet is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sonoma Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sonoma Diet and Defibrotide Sodium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Sonoma Diet

What is Sonoma Diet?

  • Weight loss
  • Heart health
  • Blood sugar control
  • Mediterranean-style eating
  • General healthy eating

The Sonoma Diet is not a supplement or herb — it is a Mediterranean-style eating plan that emphasizes whole grains, lean proteins, healthy fats, vegetables, and portion control. It is generally considered a safe, balanced way to eat, but it is a food plan rather than a pill, so talk with your doctor or dietitian before making big dietary changes.

Eating plan (whole foods, meal plans, recipes, books)

An interaction check asks whether these two react with each other — it does not ask whether Sonoma Diet is a good idea for someone in your situation. Here is what our Sonoma Diet record says about it on its own.

Sonoma Diet: dosing

There is no "dose" for the Sonoma Diet because it is an eating plan, not a supplement. Instead, you follow the plan's guidance on food choices, portion sizes, and meal structure, often described in its books or official materials.If you want to follow it, a registered dietitian can help you tailor it to your calorie needs, health conditions, and preferences.

From our Sonoma Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sonoma Diet monograph & all interactions
Medication

About Defibrotide Injection

What Is Defibrotide Injection Used For?

Brand name: Defitelio

Defitelio (defibrotide injection) is used to treat hepatic veno-occlusive disease (VOD) — also called sinusoidal obstruction syndrome (SOS) — in adult and pediatric patients. This is a serious condition where small blood vessels in the liver become blocked, most often after a hematopoietic stem-cell transplant (HSCT).

Defitelio is specifically indicated when VOD is accompanied by kidney dysfunction or pulmonary (lung) dysfunction, making it a treatment for one of the most severe forms of this complication.

Most-Reported Side Effects for Defibrotide Sodium

From FAERS, the FDA’s public side-effect reporting system (3,546 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Venoocclusive disease 564 reports
Multiple organ dysfunction syndrome 343 reports
Venoocclusive liver disease 336 reports
Hypotension 159 reports
Hemorrhage 155 reports
See full Defibrotide Injection drug information
Keep checking

Other Drugs & Sonoma Diet

Browse every other medication we’ve checked against Sonoma Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sonoma Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sonoma Diet list.

See the full Sonoma Diet interactions page
See every supplement checked against Defibrotide Sodium, ranked by severity
Evidence & sources

Sonoma Diet References

The 3 sources that drive our Sonoma Diet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Sonoma Diet is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Mediterranean Diet — MedlinePlus Source
  2. Healthy Eating Plan — NIH NHLBI Source
  3. Mediterranean Diet — Cleveland Clinic Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Sonoma Diet While Taking Defibrotide Sodium: Common Questions

Is it safe to follow Sonoma Diet while taking Defibrotide Sodium?
We do not list a known interaction between Sonoma Diet and Defibrotide Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Defibrotide Sodium interact with any supplements?
Yes. Defibrotide Sodium has documented interactions with 202 supplements in our database — Sonoma Diet is not one of them. The Defibrotide Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sonoma Diet monograph Uses, safety profile, and every drug interaction in one place Defibrotide Injection drug information The full plain-English guide to this medication Defibrotide Sodium supplement interactions Every supplement checked against Defibrotide Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Defibrotide Sodium and Sonoma Diet?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.