Drug & supplement interaction

Bugle + Dapagliflozin Propanediol, Metformin

Dapagliflozin Propanediol, Metformin brand name: Xigduo XR.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bugle and Dapagliflozin Propanediol, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Dapagliflozin Propanediol, Metformin states a food rule worth keeping to.

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Interaction report

Bugle and Dapagliflozin Propanediol, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dapagliflozin Propanediol, Metformin and Bugle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Bugle at all — not against Dapagliflozin Propanediol, Metformin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bugle safety at a glance

Bugle overall Not established There is limited modern safety data on bugle in humans.
Pregnancy Avoid Avoid because safety during pregnancy has not been established.
Breastfeeding Avoid Avoid because there is no reliable safety information while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dapagliflozin Propanediol, Metformin and Bugle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dapagliflozin Propanediol, Metformin’s Own FDA Label Lists

This is not an interaction — none of it involves Bugle. These are the most notable effects listed in the ADVERSE REACTIONS section of Dapagliflozin Propanediol, Metformin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Dehydration Worth acting on
  • Low blood sugar Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on
  • Kidney problems Worth acting on
  • A higher chance of infection Worth acting on
  • Passing urine more often
  • Pain in an arm or leg
  • Sore throat
  • Back pain

Showing the 10 most notable of 18 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Dapagliflozin Propanediol, Metformin. Read the label on DailyMed › Bugle’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bugle side to compare — that is a limit of the record, not a statement that Bugle has no side effects.

How to take them

Some Dapagliflozin Propanediol, Metformin Products Have a Food Rule — Bugle Should Not Break It

At least one FDA label for a product containing Dapagliflozin Propanediol, Metformin says to take it with food. If you take Bugle on an empty stomach out of habit, keep them separate — and take Dapagliflozin Propanediol, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Dapagliflozin Propanediol, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.3 ) • Administer orally once daily in the morning with food.

From the Dosage and Administration section of the FDA label we read for Dapagliflozin Propanediol, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Dapagliflozin Propanediol, Metformin

This page covers Bugle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dapagliflozin Propanediol, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Dapagliflozin Propanediol, Metformin page

“Siberian cocklebur is the one supplement I would flat-out avoid with Xigduo XR (dapagliflozin plus metformin). It has caused severe and worsening low blood sugar in people, a dangerous match for two glucose-lowering medicines.”

Reviewed by 2 · Jul 18, 2026

Open the Dapagliflozin Propanediol, Metformin interaction page

How much people look this up

Where Bugle and Dapagliflozin Propanediol, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bugle
Steady interest

#1,103 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dapagliflozin Propanediol, Metformin
Top half

#1,352 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Bugle is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bugle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bugle and Dapagliflozin Propanediol, Metformin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bugle

What is Bugle?

  • Minor wounds and bruises
  • Sore throat and mouth irritation
  • Mild cough
  • Digestive complaints
  • Bleeding (traditional use)

Bugle (Ajuga reptans) is a traditional European herb once used to help wounds, bruises, and mouth or throat irritation. There is very little modern scientific research to confirm any of these uses, so its benefits remain unproven. If you want to try it, talk to a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding because safety data are lacking.

Ajuga reptans · Lamiaceae · Aerial parts (leaves and flowering tops) · Dried herb, tea, tincture, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Bugle is a good idea for someone in your situation. Here is what our Bugle record says about it on its own.

Bugle: dosing

There is no established or standardized dose for bugle. Traditional use varied, and modern products are not common or well regulated.If you choose to use a bugle product, follow the directions on the label and do not exceed them.

From our Bugle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bugle monograph & all interactions
Keep checking

Other Drugs & Bugle

Browse every other medication we’ve checked against Bugle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Bugle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Bugle list.

See the full Bugle interactions page
See every supplement checked against Dapagliflozin Propanediol, Metformin, ranked by severity
Evidence & sources

Bugle References

The 1 sources that drive our Bugle monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Bugle is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bugle and Dapagliflozin Propanediol, Metformin Together: Common Questions

Is it safe to take Bugle with Dapagliflozin Propanediol, Metformin?
We do not list a known interaction between Bugle and Dapagliflozin Propanediol, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Bugle and Dapagliflozin Propanediol, Metformin at the same time of day?
At least one FDA label for a product containing Dapagliflozin Propanediol, Metformin says to take it with food. If you take Bugle on an empty stomach out of habit, keep them separate and take Dapagliflozin Propanediol, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Dapagliflozin Propanediol, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Dapagliflozin Propanediol, Metformin interact with any supplements?
Yes. Dapagliflozin Propanediol, Metformin has documented interactions with 257 supplements in our database — Bugle is not one of them. The Dapagliflozin Propanediol, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bugle monograph Uses, safety profile, and every drug interaction in one place Dapagliflozin Propanediol, Metformin supplement interactions Every supplement checked against Dapagliflozin Propanediol, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dapagliflozin Propanediol, Metformin and Bugle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.