Drug & supplement interaction

Burr Marigold + Atropine, Difenoxin

Atropine, Difenoxin brand name: Motofen.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Burr Marigold and Atropine, Difenoxin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Burr Marigold and Atropine, Difenoxin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atropine, Difenoxin and Burr Marigold in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Burr Marigold at all — not against Atropine, Difenoxin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Burr Marigold safety at a glance

Burr Marigold overall Use caution Limited human safety data, so use cautiously and discuss with a healthcare professional first.
Pregnancy Avoid Not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atropine, Difenoxin and Burr Marigold? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Atropine, Difenoxin’s Own FDA Label Lists

This is not an interaction — none of it involves Burr Marigold. These are the most notable effects listed in the ADVERSE REACTIONS section of Atropine, Difenoxin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on
  • Trouble passing urine Worth acting on
  • Pancreatitis Worth acting on
  • Confusion Worth acting on
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • Eye irritation or redness
  • Flushing
  • Blurred vision

Showing the 10 most notable of 25 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Atropine, Difenoxin. Read the label on DailyMed › Burr Marigold’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Burr Marigold side to compare — that is a limit of the record, not a statement that Burr Marigold has no side effects.

Everything else you take

See Every Supplement That Interacts With Atropine, Difenoxin

This page covers Burr Marigold only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atropine, Difenoxin page lists 47 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 12 minor.

From our pharmacist’s overview on the Atropine, Difenoxin page

“Motofen pairs difenoxin with a small dose of atropine to slow diarrhea, and its 47 interacting supplements warrant genuine care, three of them rated major. Most entries, 30 in all, pile extra anticholinergic effects on the atropine, meaning worse dry mouth, blurred vision, constipation, and confusion.”

Reviewed by 2 · Jul 18, 2026

Open the Atropine, Difenoxin interaction page

How much people look this up

Where Burr Marigold and Atropine, Difenoxin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Burr Marigold
Steady interest

#1,441 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atropine, Difenoxin
Top half

#1,392 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Burr Marigold is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Burr Marigold reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Burr Marigold and Atropine, Difenoxin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Burr Marigold

What is Burr Marigold?

Burr Marigold
  • Minor wounds and skin irritation
  • Mild urinary complaints
  • Digestive upset
  • Coughs and colds
  • General 'cleansing' or diuretic effect

Burr Marigold (Bidens tripartita) is a wetland plant used in traditional medicine for wounds, urinary complaints, and digestive issues, but high-quality human research is lacking. Because its effectiveness and safety have not been well studied, it should be used cautiously, and avoided in pregnancy, breastfeeding, and in young children. Talk to a pharmacist or doctor before trying it.

Bidens tripartita · Asteraceae · Above-ground parts (herb), including leaves, stems, and flowering tops · Tea (dried herb infusion), tincture, liquid extract, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Burr Marigold is a good idea for someone in your situation. Here is what our Burr Marigold record says about it on its own.

Burr Marigold: dosing

There is no established standard dose for Burr Marigold. Traditional use has involved teas made from the dried herb, as well as tinctures and liquid extracts, but reliable dosing guidelines from clinical research do not exist.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Burr Marigold monograph — the full record covers uses, side effects and every documented interaction.

Read the full Burr Marigold monograph & all interactions
Keep checking

Other Drugs & Burr Marigold

Browse every other medication we’ve checked against Burr Marigold — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Burr Marigold against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Burr Marigold list.

See the full Burr Marigold interactions page
See every supplement checked against Atropine, Difenoxin, ranked by severity
Evidence & sources

Burr Marigold References

The 2 sources that drive our Burr Marigold monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Burr Marigold is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. MedlinePlus: Herbal Medicine — MedlinePlus (NIH) Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Burr Marigold and Atropine, Difenoxin Together: Common Questions

Is it safe to take Burr Marigold with Atropine, Difenoxin?
We do not list a known interaction between Burr Marigold and Atropine, Difenoxin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Atropine, Difenoxin interact with any supplements?
Yes. Atropine, Difenoxin has documented interactions with 47 supplements in our database — Burr Marigold is not one of them. The Atropine, Difenoxin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Burr Marigold monograph Uses, safety profile, and every drug interaction in one place Atropine, Difenoxin supplement interactions Every supplement checked against Atropine, Difenoxin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atropine, Difenoxin and Burr Marigold?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.