Buttercup + Ospemifene
Ospemifene brand name: Osphena.
We found no known interaction between Buttercup and Ospemifene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ospemifene states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Buttercup and Ospemifene
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ospemifene and Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Buttercup at all — not against Ospemifene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Buttercup safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Buttercup in Pregnancy & Breastfeeding
When the fresh plant is used orally or topically. Buttercup might also stimulate uterine contractions. There is insufficient reliable information available about the safety of the dried above ground parts of buttercup used during pregnancy and lactation.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Ospemifene Products Have a Food Rule — Buttercup Should Not Break It
At least one FDA label for a product containing Ospemifene says to take it with food. If you take Buttercup on an empty stomach out of habit, keep them separate — and take Ospemifene with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ospemifene products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
One tablet taken orally once daily with food.
From the Dosage and Administration section of the FDA label we read for Ospemifene — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Ospemifene
This page covers Buttercup only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ospemifene page lists 155 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Tiratricol (major) and Acacia Rigidula (moderate).
By severity: 4 major · 112 moderate · 39 minor.
From our pharmacist’s overview on the Ospemifene page
“Women prescribed ospemifene (Osphena) for painful intercourse after menopause are often the same women reaching for St. John's wort for mood or grapefruit juice at breakfast, and both sit among the four major-rated interactions on this page, so the list deserves genuine care.”
Reviewed by 2 · Jul 18, 2026
Where Buttercup and Ospemifene Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,102 of 1,452 supplements looked up here in the last 7 days
#1,653 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Buttercup reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Buttercup and Ospemifene records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Buttercup
What is Buttercup?
- Joint and muscle pain (traditional topical use)
- Skin conditions and blisters
- Nerve pain (traditional folk use)
- Rheumatic complaints
Buttercup refers to plants in the Ranunculus family, which contain an irritating compound that makes the fresh plant toxic to eat and harsh on skin. There is no good scientific evidence that it safely treats any health condition, and it can cause serious irritation and poisoning. We do not recommend using fresh buttercup as a supplement.
Ranunculus spp. · Ranunculaceae · Whole plant, leaves, and flowers (fresh or dried) · Topical preparations, homeopathic remedies, traditional poultices, and dried herb
An interaction check asks whether these two react with each other — it does not ask whether Buttercup is a good idea for someone in your situation. Here is what our Buttercup record says about it on its own.
Buttercup: dosing
There is no established safe dose of buttercup for internal use, and we do not recommend taking it by mouth. The plant is toxic in its fresh form, and standardized supplement products are not available from reputable sources.Any homeopathic preparations are extremely diluted and are a different category of product.
From our Buttercup monograph — the full record covers uses, side effects and every documented interaction.
About Ospemifene
What Is Ospemifene Used For?
Brand name: Osphena
Osphena (ospemifene) is used to treat two specific symptoms of vulvar and vaginal atrophy — the thinning and drying of vaginal tissues that can happen after menopause. The first is moderate to severe dyspareunia (painful intercourse), and the second is moderate to severe vaginal dryness.
Both of these uses are for postmenopausal women only. Osphena is not used in children or in women who are pregnant or may become pregnant.
Most-Reported Side Effects for Ospemifene
From FAERS, the FDA’s public side-effect reporting system (2,601 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Buttercup
Browse every other medication we’ve checked against Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Buttercup against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Buttercup list.
Buttercup References
The 3 references that drive our Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- de Maere d'Aertrycke O, Le Polain de Waroux JB, Hantson P, de Bergeyck R. Recurrent supraventricular tachyarrhythmia following Ranunculus acris ("Meadow Buttercup") ingestion. Clin Toxicol (Phila). 2020;58(7):780-781.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Buttercup and Ospemifene Together: Common Questions
Is it safe to take Buttercup with Ospemifene?
Do Buttercup and Ospemifene have any of the same side effects?
Should I take Buttercup and Ospemifene at the same time of day?
Does Ospemifene interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Ospemifene and Buttercup?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.