Drug & supplement interaction

Butternut + Fenofibrate

Fenofibrate brand names: Tricor, Fenofibrate, Lipidil Micro, Lipidil Supra, Antara, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Butternut and Fenofibrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Butternut and Fenofibrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fenofibrate and Butternut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Butternut safety at a glance

Butternut overall Use caution Limited safety data; it acts as a laxative and may cause cramping or digestive upset.
Pregnancy Likely Unsafe When used orally in large amounts, it can be cathartic; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally in large amounts, it can be cathartic; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fenofibrate and Butternut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fenofibrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fenofibrate is filed under 3 classifications — cytochrome p450 2c9 (cyp2c9) inhibitors, hepatotoxic drugs, oral drugs. Butternut has documented interactions with 5 drug classes — the most serious being corticosteroids (moderate), digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Fenofibrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Butternut Does Interact With Other Medications

Butternut has 122 moderate known drug interactions in our database — Fenofibrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Fenofibrate)
Taking anything else?

Check Another of Your Medications Against Butternut

Covers the 2,830 medications we’ve checked against Butternut. Pick one to open its full report.

What to actually watch for

What Butternut Itself Has Been Linked To

This is not an interaction — nothing below involves Fenofibrate. It is the side-effect record for Butternut on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Butternut, this list is the first place to look.

  • Diarrhea Additional detail

    “Orally, butternut seems to be well tolerated. It can cause diarrhea and gastrointestinal irritation (19).”

    Butternut · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    “Orally, butternut can cause diarrhea and gastrointestinal irritation (19).”

    Butternut · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Everything above comes from the Natural Medicines adverse-effect record for Butternut — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Fenofibrate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Fenofibrate column appears here.

Special populations

Butternut in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally in large amounts, it can be cathartic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Fenofibrate

This page covers Butternut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fenofibrate page lists 59 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 46 moderate · 9 minor.

From our pharmacist’s overview on the Fenofibrate page

“Fenofibrate (Tricor, Antara) is a cholesterol and triglyceride medicine that can strain the liver on its own, so this list of 59 supplements deserves genuine care rather than a shrug. Most of it, 38 ingredients, involves herbs that also stress the liver, ashwagandha among them, and stacking those effects is the risk that matters most h…”

Reviewed by 2 · Jul 18, 2026

Open the Fenofibrate interaction page

One more smart check

Taking Butternut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 168 real supplement products containing Butternut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Butternut. Even though Butternut itself has no known interaction with Fenofibrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Butternut and Fenofibrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Butternut
Top half

#452 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fenofibrate
Top half

#1,114 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Butternut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Butternut and Fenofibrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Butternut

What is Butternut?

  • Constipation (laxative)
  • Digestive complaints
  • Skin conditions
  • Traditional 'liver' or 'cleansing' remedy
  • Mild laxative in herbal blends

Butternut (Juglans cinerea) is a North American tree whose inner bark was traditionally used as a mild laxative and folk remedy. Modern scientific evidence supporting any of its uses is very limited, and it can cause stomach cramping and other effects, so it should be used cautiously and only with guidance from a healthcare professional.

Juglans cinerea · Juglandaceae · Inner bark (and sometimes nut, leaves, and bark of the root) · Dried bark, tinctures, capsules, and teas

An interaction check asks whether these two react with each other — it does not ask whether Butternut is a good idea for someone in your situation. Here is what our Butternut record says about it on its own.

Butternut: dosing

There is no well-established or standardized dose for butternut. Traditional preparations varied widely, and the strength of commercial products is not consistent.If you choose to use a butternut product, follow the directions on the label and do not exceed the suggested amount.

From our Butternut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Butternut monograph & all interactions
Medication

About Fenofibrate

What Is Fenofibrate Used For?

Brand names: Tricor, Fenofibrate, Lipidil Micro, Lipidil Supra, Antara, Lofibra, Triglide, Lipidil EZ

Fenofibrate is used alongside a cholesterol-lowering diet in adults to improve abnormal lipid levels. Tricor (tablet) and fenofibrate tablets are indicated to lower LDL cholesterol (bad cholesterol), total cholesterol, triglycerides, and apolipoprotein B, and to raise HDL cholesterol (good cholesterol) in adults with primary hypercholesterolemia (high cholesterol) or mixed dyslipidemia (mixed abnormal lipid levels). They are also used to treat severe hypertriglyceridemia (very high triglycerides).

Antara and Lipofen (capsules) are indicated to reduce triglyceride levels in adults with severe hypertriglyceridemia, and to lower LDL cholesterol in adults with primary hyperlipidemia when other recommended LDL-lowering therapies cannot be used. Fenofibrate has not been shown to reduce heart attacks or cardiovascular deaths in patients with type 2 diabetes.

Most-Reported Side Effects for Fenofibrate

From FAERS, the FDA’s public side-effect reporting system (35,249 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 2,173 reports
Diarrhea 2,103 reports
Nausea 2,045 reports
Headache 1,571 reports
Dyspnea 1,527 reports
See full Fenofibrate drug information
Keep checking

Other Drugs & Butternut

Browse every other medication we’ve checked against Butternut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Butternut page.

No interaction 2,707 drugs checked — show the list

We also checked Butternut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Butternut list.

See the full Butternut interactions page
See every supplement checked against Fenofibrate, ranked by severity
Evidence & sources

Butternut References

The 3 references that drive our Butternut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Butternut and Fenofibrate Together: Common Questions

Is it safe to take Butternut with Fenofibrate?
We do not list a known interaction between Butternut and Fenofibrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Butternut and Fenofibrate combination checked?
Interactions in our licensed database are recorded against drug classes. Fenofibrate is filed under 3 classifications, and Butternut has documented interactions with 5 drug classes — none of Fenofibrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Butternut interact with any other medications?
Yes. Butternut has 122 documented drug interactions in our database — Fenofibrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fenofibrate interact with any supplements?
Yes. Fenofibrate has documented interactions with 59 supplements in our database — Butternut is not one of them. The Fenofibrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Butternut monograph Uses, safety profile, and every drug interaction in one place Fenofibrate drug information The full plain-English guide to this medication Fenofibrate supplement interactions Every supplement checked against Fenofibrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fenofibrate and Butternut?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.