Drug & supplement interaction

Butternut + Rosuvastatin

Rosuvastatin brand names: Crestor, Ezallor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Butternut and Rosuvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Butternut and Rosuvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rosuvastatin and Butternut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Butternut safety at a glance

Butternut overall Use caution Limited safety data; it acts as a laxative and may cause cramping or digestive upset.
Pregnancy Likely Unsafe When used orally in large amounts, it can be cathartic; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally in large amounts, it can be cathartic; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rosuvastatin and Butternut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Rosuvastatin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Rosuvastatin is filed under 4 classifications — including hmg-coa reductase inhibitors ("statins"), hepatotoxic drugs, oral drugs. Butternut has documented interactions with 5 drug classes — the most serious being corticosteroids (moderate), digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Rosuvastatin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Butternut Does Interact With Other Medications

Butternut has 122 moderate known drug interactions in our database — Rosuvastatin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Rosuvastatin)
Taking anything else?

Check Another of Your Medications Against Butternut

Covers the 2,830 medications we’ve checked against Butternut. Pick one to open its full report.

What to actually watch for

What Butternut Itself Has Been Linked To

This is not an interaction — nothing below involves Rosuvastatin. It is the side-effect record for Butternut on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Butternut, this list is the first place to look.

  • Diarrhea Additional detail

    “Orally, butternut seems to be well tolerated. It can cause diarrhea and gastrointestinal irritation (19).”

    Butternut · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    “Orally, butternut can cause diarrhea and gastrointestinal irritation (19).”

    Butternut · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Everything above comes from the Natural Medicines adverse-effect record for Butternut — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Rosuvastatin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Rosuvastatin column appears here.

Special populations

Butternut in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally in large amounts, it can be cathartic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Butternut or Rosuvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Butternut or Rosuvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Rosuvastatin

This page covers Butternut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rosuvastatin page lists 63 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 48 moderate · 10 minor.

From our pharmacist’s overview on the Rosuvastatin page

“Rosuvastatin (Crestor, Ezallor) is a statin taken daily for years to lower cholesterol, and its supplement list deserves real scrutiny, not a quick skim. Five of the 63 ingredients on file carry a major rating, headed by grapefruit, which can raise statin blood levels, and by heavy drinking, since beer and wine compound the strain this…”

Reviewed by 2 · Jul 18, 2026

Open the Rosuvastatin interaction page

One more smart check

Taking Butternut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 168 real supplement products containing Butternut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Butternut. Even though Butternut itself has no known interaction with Rosuvastatin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Butternut and Rosuvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Butternut
Steady interest

#813 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rosuvastatin
Top 10

#9 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Butternut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Butternut and Rosuvastatin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Butternut

What is Butternut?

  • Constipation (laxative)
  • Digestive complaints
  • Skin conditions
  • Traditional 'liver' or 'cleansing' remedy
  • Mild laxative in herbal blends

Butternut (Juglans cinerea) is a North American tree whose inner bark was traditionally used as a mild laxative and folk remedy. Modern scientific evidence supporting any of its uses is very limited, and it can cause stomach cramping and other effects, so it should be used cautiously and only with guidance from a healthcare professional.

Juglans cinerea · Juglandaceae · Inner bark (and sometimes nut, leaves, and bark of the root) · Dried bark, tinctures, capsules, and teas

An interaction check asks whether these two react with each other — it does not ask whether Butternut is a good idea for someone in your situation. Here is what our Butternut record says about it on its own.

Butternut: dosing

There is no well-established or standardized dose for butternut. Traditional preparations varied widely, and the strength of commercial products is not consistent.If you choose to use a butternut product, follow the directions on the label and do not exceed the suggested amount.

From our Butternut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Butternut monograph & all interactions
Medication

About Rosuvastatin

What Is Rosuvastatin Used For?

Brand names: Crestor, Ezallor

Rosuvastatin tablets are used alongside diet changes to lower LDL-C ("bad" cholesterol), total cholesterol, and triglycerides (blood fats), and to raise HDL-C ("good" cholesterol) in adults with high cholesterol or mixed cholesterol problems. They are also used in adults with very high triglycerides, a condition called primary dysbetalipoproteinemia (Type III, a genetic fat-metabolism disorder), and to slow the buildup of plaque in arteries (atherosclerosis).

In people without established heart disease but with multiple risk factors, rosuvastatin tablets can reduce the risk of heart attack, stroke, and procedures to open blocked arteries. For children and teens aged 8 and older with heterozygous familial hypercholesterolemia (HeFH, an inherited high-cholesterol condition), the tablet form is used to lower LDL-C after diet alone has not worked. Crestor tablets are also approved to treat homozygous familial hypercholesterolemia (HoFH, a more severe inherited form) in adults and in children aged 7 and older.

Most-Reported Side Effects for Rosuvastatin

From FAERS, the FDA’s public side-effect reporting system (229,715 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,778 reports
Nausea 12,432 reports
Dyspnea 11,981 reports
Diarrhea 11,370 reports
Headache 10,154 reports
See full Rosuvastatin drug information
Keep checking

Other Drugs & Butternut

Browse every other medication we’ve checked against Butternut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Butternut page.

No interaction 2,707 drugs checked — show the list

We also checked Butternut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Butternut list.

See the full Butternut interactions page
See every supplement checked against Rosuvastatin, ranked by severity
Evidence & sources

Butternut References

The 3 references that drive our Butternut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Butternut and Rosuvastatin Together: Common Questions

Is it safe to take Butternut with Rosuvastatin?
We do not list a known interaction between Butternut and Rosuvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Butternut and Rosuvastatin combination checked?
Interactions in our licensed database are recorded against drug classes. Rosuvastatin is filed under 4 classifications, and Butternut has documented interactions with 5 drug classes — none of Rosuvastatin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Butternut interact with any other medications?
Yes. Butternut has 122 documented drug interactions in our database — Rosuvastatin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Rosuvastatin interact with any supplements?
Yes. Rosuvastatin has documented interactions with 63 supplements in our database — Butternut is not one of them. The Rosuvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Butternut monograph Uses, safety profile, and every drug interaction in one place Rosuvastatin drug information The full plain-English guide to this medication Rosuvastatin supplement interactions Every supplement checked against Rosuvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Rosuvastatin and Butternut?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.