We found no known interaction between Cade and Trastuzumab-Dkst in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Trastuzumab-Dkst and Cade in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Cade at all — not against Trastuzumab-Dkst, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cade safety at a glance
Cade overall
Use cautionGenerally used topically only and in small amounts; not for internal use and best used under guidance.
Pregnancy
AvoidSafety has not been established, so avoid use during pregnancy.
Breastfeeding
AvoidNot enough safety information, so avoid use while breastfeeding.
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
No Interaction Found — But Data Suggests Cade and Trastuzumab-Dkst May Share Several of the Same Side Effects
This is not an interaction. Neither one changes how your body handles the other, and
nothing here says they react together. What our sources do show is that each has
separately been linked to the effects below — so taking both can make those effects
more likely to turn up, and harder to pin on one or the other if they do.
7 of them are
worth acting on rather than waiting out — marked below.
Heart failureWorth acting onAdditional detail
Cade
“Topical application of rectified cade oil 1% to 5% is well tolerated (16). Oral use of rectified or crude cade oil and topical use of crude cade oil are associated with serious adverse effects when taken either in single or multiple doses. Adverse effects associated with topical application generally occur in infants and children.”
16.Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
94770.Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed ↗
94772.Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed ↗
57209.Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed ↗
94776.Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
“Oral ingestion and topical application of cade oil have been associated with hypotension, tachycardia, and heart failure.”
94770.Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed ↗
94776.Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
A low platelet count / Anemia / A low white blood cell countWorth acting onAdditional detail
Cade
“Oral ingestion and topical application of cade oil have been associated with anemia, leukopenia, neutropenia, and thrombocytopenia.”
Cade · Natural Medicines adverse-effect record, reported in anemia.
2 sources cited
57209.Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed ↗
94772.Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed ↗
“Oral ingestion and topical application of cade oil can result in acute renal failure (16,57209,94770,94772).”
Cade · Natural Medicines adverse-effect record, reported in kidney failure.
4 sources cited
16.Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
57209.Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed ↗
94770.Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed ↗
94772.Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed ↗
94770.Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed ↗
94776.Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
Bleeding or bruisingWorth acting onAdditional detail
Cade
“Topical application of cade oil can cause urticaria, localized edema, and purpura. After oral ingestion of a "spoonful" of homemade cade oil, a 32-year old man developed a maculopapular rash with pustular lesions around the nose and mouth.”
Cade · Natural Medicines adverse-effect record, reported in pregnancy-related edema.
2 sources cited
94772.Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed ↗
57209.Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed ↗
“Oral ingestion of a "spoonful" of homemade cade oil was associated with gingival erosions, nausea, vomiting, and dyspepsia in a 32-year old man.”
Cade · Natural Medicines adverse-effect record, reported in dyspepsia.
1 source cited
57209.Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed ↗
Showing the 10 most notable of 16 shared effects — ranked by how unusual each one is, not just whether both lists mention it.
Reported for Cade but not commonly for Trastuzumab-Dkst: an electrolyte imbalance, seizures, low blood pressure and drowsiness.
Effects for Trastuzumab-Dkst come from the ADVERSE REACTIONS section of its FDA label; effects for
Cade come from the Natural Medicines adverse-effect record, quoted above.
Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.
💊Everything else you take
See Every Supplement That Interacts With Trastuzumab-Dkst
This page covers Cade only. If you take other supplements — a multivitamin, a
sleep aid, something for joints — the Trastuzumab-Dkst page lists
1 supplement
it has a documented interaction with, worst first, each one explained.
From our pharmacist’s overview on the Trastuzumab-Dkst page
“This is one of the shortest interaction lists on the site. Trastuzumab-dkst (Ogivri), an antibody infusion for HER2-positive breast and stomach cancers, has exactly one supplement interaction on record, and it is rated minor.”
Where Cade and Trastuzumab-Dkst Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
SupplementCade
Steady interest
#1,208 of 1,452
supplements looked up here in the last 7 days
29 days agotoday
MedicationTrastuzumab-Dkst
Top 25%
#484 of 2,830
medications looked up here in the last 7 days
29 days agotoday
Position among everything looked up on this site, not a measure of how commonly either one is
used or how important it is. A supplement can climb this list because of a news story.
It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
See every Cade reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cade and Trastuzumab-Dkst records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Cade oil (juniper tar) is a dark, tar-like oil distilled from the wood of the prickly juniper and is used almost entirely on the skin and scalp for conditions like psoriasis, eczema, and dandruff. Good-quality human research is limited, and there are real safety concerns, so it should only be used on the skin, carefully and in small amounts. Talk with a pharmacist or doctor before using it, and never take it by mouth.
Juniperus oxycedrus · Cupressaceae · Wood and branches, used to make cade oil (juniper tar) · Cade oil (juniper tar), topical creams, ointments, shampoos, and soaps
An interaction check asks whether these two react with each other — it does not ask whether Cade is a good idea for someone in your situation. Here is what our Cade record says about it on its own.
Cade: dosing
There is no established standard dose for cade oil. It is most often found already mixed into shampoos, soaps, creams, or ointments at low concentrations rather than used as a pure oil.The best approach is to follow the directions on the product label and not apply more or more often than recommended.
From our Cade monograph — the full record covers uses, side effects and every documented interaction.
Browse every other medication we’ve checked against Cade — both the ones with a known interaction and the ones without. Select any drug for the full detail.
The 5 references that drive our Cade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed ↗
Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed ↗
Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed ↗
Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
Taking Cade and Trastuzumab-Dkst Together: Common Questions
Is it safe to take Cade with Trastuzumab-Dkst?
We do not list a known interaction between Cade and Trastuzumab-Dkst. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cade and Trastuzumab-Dkst have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Trastuzumab-Dkst interact with any supplements?
Yes. Trastuzumab-Dkst has documented interactions with 1 supplement in our database — Cade is not one of them. The Trastuzumab-Dkst interaction page linked on this page lists every one, ranked by severity.
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Browse interactions for other vitamins, herbs, and supplements.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
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