Drug & supplement interaction

Calendula + tislelizumab-jsgr

tislelizumab-jsgr brand name: Tevimbra.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Calendula and tislelizumab-jsgr in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Calendula and tislelizumab-jsgr

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between tislelizumab-jsgr and Calendula in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calendula safety at a glance

Calendula overall Use caution Generally well tolerated on the skin, but can cause allergic reactions in sensitive people.
Pregnancy Likely Unsafe When used orally; contraindicated due to spermatocide, antiblastocyst, and abortifacient effects. There is insufficient reliable information available about the... Read the full pregnancy detail
Breastfeeding Use caution Reliable safety information is lacking, so it is best to avoid oral use unless your doctor approves.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining tislelizumab-jsgr and Calendula? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for tislelizumab-jsgr

Interactions in our licensed database are recorded against drug classes, not just single drug names. tislelizumab-jsgr is filed under 2 classifications — nephrotoxic drugs, hepatotoxic drugs. Calendula has documented interactions with 1 drug class — the most serious being cns depressants (minor) — and none of tislelizumab-jsgr’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calendula Does Interact With Other Medications

Calendula has 248 minor known drug interactions in our database — tislelizumab-jsgr isn’t one of them. If you take anything else, check it against the full list below.

Minor 248 No known interaction 2,582 (incl. tislelizumab-jsgr)
Taking anything else?

Check Another of Your Medications Against Calendula

Covers the 2,830 medications we’ve checked against Calendula. Pick one to open its full report.

What to actually watch for

What Calendula Itself Has Been Linked To

This is not an interaction — nothing below involves tislelizumab-jsgr. It is the side-effect record for Calendula on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Calendula, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / Hives / An allergic reaction Worth acting on Additional detail

    “Orally, calendula can cause allergic reactions. Topically, calendula can cause eczematous allergic reactions. Calendula-specific patch testing is recommended prior to usage to determine allergenic potential. Testing is particularly necessary in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs.”

    Calendula · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 10691. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
    2. 11458. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
    3. 96647. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
    4. 11152. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  • Itching Additional detail

    “Topically, a preparation containing calendula powder 0.1% resulted in inflammation around the wound to which it was applied. Burning sensation, itching, redness, and scaling were reported rarely in patients applying a combination of calendula, licorice, and snail secretion filtrate to the face. The specific role of calendula is unclear.”

    Calendula · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 96647. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
    2. 110322. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

Everything above comes from the Natural Medicines adverse-effect record for Calendula — expand a row for the licensed statement it rests on. We haven’t matched tislelizumab-jsgr to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for tislelizumab-jsgr.

Special populations

Calendula in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; contraindicated due to spermatocide, antiblastocyst, and abortifacient effects. There is insufficient reliable information available about the safety of calendula when used topically during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Calendula or tislelizumab-jsgr

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calendula or tislelizumab-jsgr, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With tislelizumab-jsgr

This page covers Calendula only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the tislelizumab-jsgr page lists 42 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Aristolochia (moderate).

By severity: 4 major · 37 moderate · 1 minor.

From our pharmacist’s overview on the tislelizumab-jsgr page

“Alcohol, even ordinary beer and wine, sits at the top of my concerns for anyone receiving tislelizumab-jsgr (Tevimbra), an immunotherapy for certain cancers of the esophagus and stomach. Drugs in this class can provoke immune attacks on the liver, and 38 of the 42 supplement ingredients on this page add liver stress of their own, so ne…”

Reviewed by 2 · Jul 18, 2026

Open the tislelizumab-jsgr interaction page

One more smart check

Taking Calendula as Part of a Dietary Supplement Product? Check It for Interactions

We hold 214 real supplement products containing Calendula, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calendula. Even though Calendula itself has no known interaction with tislelizumab-jsgr, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Calendula and tislelizumab-jsgr Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calendula
Top half

#479 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication tislelizumab-jsgr
Steady interest

#1,559 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calendula reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Calendula and tislelizumab-jsgr records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calendula

What is Calendula?

Calendula
  • Minor wounds and skin healing
  • Skin inflammation and irritation
  • Diaper rash
  • Mouth and throat inflammation
  • Soothing dry or chapped skin

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for skin and mouth uses, but the overall evidence is limited. It is generally well tolerated on the skin, but people allergic to ragweed, daisies, or marigolds should be cautious.

Calendula officinalis · Asteraceae · Flowers (petals/florets) · Topical creams, ointments, gels, oils, tinctures, teas, mouth rinses

An interaction check asks whether these two react with each other — it does not ask whether Calendula is a good idea for someone in your situation. Here is what our Calendula record says about it on its own.

Calendula: dosing

There is no official, standardized dose for calendula. The amount used depends on the product and how it is being used, such as a cream, oil, tincture, or tea.The best approach is to follow the directions on the product label and to choose products from reputable brands.

From our Calendula monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calendula monograph & all interactions
Medication

About tislelizumab-jsgr

Most-Reported Side Effects for tislelizumab-jsgr

From FAERS, the FDA’s public side-effect reporting system (177 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 64 reports
Malignant neoplasm progression 22 reports
Anemia 21 reports
Lymphadenopathy 19 reports
Thrombocytopenia 19 reports
Keep checking

Other Drugs & Calendula

Browse every other medication we’ve checked against Calendula — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
248Minor
2,581No known interaction
248 Minor 2,581 No interaction
Minor

248 interactions

Showing 60 of 248 minor interactions — see all 248 on the Calendula page.

No interaction 2,581 drugs checked — show the list

We also checked Calendula against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Calendula list.

See the full Calendula interactions page
See every supplement checked against tislelizumab-jsgr, ranked by severity
Evidence & sources

Calendula References

The 9 references that drive our Calendula monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calendula and tislelizumab-jsgr Together: Common Questions

Is it safe to take Calendula with tislelizumab-jsgr?
We do not list a known interaction between Calendula and tislelizumab-jsgr. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Calendula and tislelizumab-jsgr combination checked?
Interactions in our licensed database are recorded against drug classes. tislelizumab-jsgr is filed under 2 classifications, and Calendula has documented interactions with 1 drug class — none of tislelizumab-jsgr's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calendula interact with any other medications?
Yes. Calendula has 248 documented drug interactions in our database — tislelizumab-jsgr is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does tislelizumab-jsgr interact with any supplements?
Yes. tislelizumab-jsgr has documented interactions with 42 supplements in our database — Calendula is not one of them. The tislelizumab-jsgr interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calendula monograph Uses, safety profile, and every drug interaction in one place tislelizumab-jsgr supplement interactions Every supplement checked against tislelizumab-jsgr, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About tislelizumab-jsgr and Calendula?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.