Drug & supplement interaction

Cannabidivarin (cbdv) + Fentanyl

Fentanyl brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cannabidivarin (cbdv) and Fentanyl in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Cannabidivarin (cbdv) and Fentanyl

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fentanyl and Cannabidivarin (cbdv) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cannabidivarin (cbdv) at all — not against Fentanyl, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabidivarin (cbdv) safety at a glance

Cannabidivarin (cb... overall Not established Human safety data are very limited, so long-term effects are not well understood.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fentanyl and Cannabidivarin (cbdv)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Cannabidivarin (cbdv) and Fentanyl May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Confusion Worth acting on Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin has been associated with dizziness, somnolence, and headache. Ataxia, confusion, and dysarthria have been reported in one patient in a clinical trial who had been taking cannabidivarin 800 mg twice daily for 30 days. This patient also experienced other symptoms of intoxication, including arterial hypotension, nystagmus, diplopia, and elevated liver transaminases.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
    2. 110246. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

    “Orally, arterial hypotension has been reported in one patient in a clinical trial who had been taking cannabidivarin 800 mg twice daily for 30 days. This patient also experienced other symptoms of intoxication, including severe ataxia, nystagmus, diplopia, dysarthria, mild confusion, and elevated liver transaminases.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in hypotension.

    1 source cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed ›

  • Kidney problems Worth acting on Additional detail

    Cannabidivarin (cbdv)

    “Orally, azotemia and acute kidney failure have been reported in one patient in a clinical trial who had been taking cannabidivarin 800 mg twice daily for 32 days. Kidney failure resolved after treatment discontinuation.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed ›

  • Tremor or shakiness Additional detail

    Cannabidivarin (cbdv)

    Recorded for Cannabidivarin (cbdv) in the same Natural Medicines adverse-effect record shown under Confusion above.

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Cannabidivarin (cbdv)

    Recorded for Cannabidivarin (cbdv) in the same Natural Medicines adverse-effect record shown under Confusion above.

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed ›

  • Drowsiness / Dizziness Additional detail

    Cannabidivarin (cbdv)

    Recorded for Cannabidivarin (cbdv) in the same Natural Medicines adverse-effect record shown under Kidney problems above.

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Nausea reported in 5.0% of FDA reports for Fentanyl Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin has been associated with diarrhea, nausea, and abdominal pain. Drooling has been reported in one child with Rett syndrome.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
    2. 110246. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin 800 mg twice daily has been associated with maculopapular rash. The rash resolved with discontinuation of cannabidivarin.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed ›

Showing the 10 most notable of 11 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Cannabidivarin (cbdv) but not commonly for Fentanyl: unsteadiness.

Effects for Fentanyl come from the ADVERSE REACTIONS section of its FDA label; effects for Cannabidivarin (cbdv) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 114,883 voluntary FDA FAERS reports for Fentanyl that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Cannabidivarin (cbdv) or Fentanyl

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cannabidivarin (cbdv) or Fentanyl, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fentanyl

This page covers Cannabidivarin (cbdv) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fentanyl page lists 226 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 10 major · 176 moderate · 40 minor.

From our pharmacist’s overview on the Fentanyl page

“There is very little room for error with fentanyl (Duragesic, Sublimaze, Actiq, and other forms), a powerful opioid where a modest rise in blood level or an extra layer of sedation can become dangerous, so this interaction list deserves real respect. Most of the risk falls into two patterns.”

Reviewed by 2 · Jul 18, 2026

Open the Fentanyl interaction page

How much people look this up

Where Cannabidivarin (cbdv) and Fentanyl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabidivarin (cbdv)
Steady interest

#1,239 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fentanyl
Top 25%

#563 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabidivarin (cbdv) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cannabidivarin (cbdv) and Fentanyl records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cannabidivarin (cbdv)

What is Cannabidivarin (cbdv)?

  • Epilepsy and seizures
  • Autism spectrum disorder
  • Rett syndrome
  • Fragile X syndrome
  • Nausea
  • Anxiety

Cannabidivarin (CBDV) is a non-intoxicating compound found in cannabis that is being studied mainly for epilepsy and certain neurodevelopmental conditions. The research is still early, mostly from laboratory and animal studies plus small human trials, so it is not an approved or proven treatment. Talk to your pharmacist or doctor before trying any CBDV product.

Cannabaceae · Compound derived from the flowers and leaves of the cannabis plant · Oils, tinctures, isolates, and research-grade formulations

An interaction check asks whether these two react with each other — it does not ask whether Cannabidivarin (cbdv) is a good idea for someone in your situation. Here is what our Cannabidivarin (cbdv) record says about it on its own.

Cannabidivarin (cbdv): dosing

There is no established standard dose for CBDV. The amounts used in research studies were chosen for those specific trials and are not the same as general supplement guidance.If you choose to use a CBDV product, follow the directions on the product label and start low.

From our Cannabidivarin (cbdv) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabidivarin (cbdv) monograph & all interactions
Medication

About Fentanyl

What Is Fentanyl Used For?

Brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, Subsys

Fentanyl transdermal system is prescribed for severe, persistent pain that cannot be controlled with other pain medicines, including shorter-acting opioids. It is only for people who are already opioid-tolerant — meaning they've been taking a significant daily opioid dose for at least a week.

It is not for short-term pain, post-surgical pain, mild pain, or use on an as-needed basis. Because of serious risks including addiction, overdose, and death, it is reserved for situations where other treatment options have failed or are not appropriate.

Most-Reported Side Effects for Fentanyl

From FAERS, the FDA’s public side-effect reporting system (114,883 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug abuse 12,447 reports
Overdose 8,162 reports
Toxicity to various agents 7,374 reports
Drug dependence 6,445 reports
Nausea 5,689 reports
See full Fentanyl drug information
Keep checking

Other Drugs & Cannabidivarin (cbdv)

Browse every other medication we’ve checked against Cannabidivarin (cbdv) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cannabidivarin (cbdv) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cannabidivarin (cbdv) list.

See the full Cannabidivarin (cbdv) interactions page
See every supplement checked against Fentanyl, ranked by severity
Evidence & sources

Cannabidivarin (cbdv) References

The 4 references that drive our Cannabidivarin (cbdv) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. European Medicines Agency. Public summary of opinion on orphan designation: Cannabidivarin for treatment of fragile X syndrome. Available at: https://www.ema.europa.eu/en/documents/orphan-designation/eu/3/18/1977-public-summary-opinion-orphan-designation-
  2. US Food and Drug Administration. Orphan Drug Designations and Approvals. Available at: https://www.accessdata.fda.gov/scripts/opdlisting/oopd/. Accessed on March 19, 2021.
  3. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
  4. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabidivarin (cbdv) and Fentanyl Together: Common Questions

Is it safe to take Cannabidivarin (cbdv) with Fentanyl?
We do not list a known interaction between Cannabidivarin (cbdv) and Fentanyl. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cannabidivarin (cbdv) and Fentanyl have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Fentanyl interact with any supplements?
Yes. Fentanyl has documented interactions with 226 supplements in our database — Cannabidivarin (cbdv) is not one of them. The Fentanyl interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cannabidivarin (cbdv) monograph Uses, safety profile, and every drug interaction in one place Fentanyl drug information The full plain-English guide to this medication Fentanyl supplement interactions Every supplement checked against Fentanyl, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fentanyl and Cannabidivarin (cbdv)?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.