Drug & supplement interaction

Cannabidivarin (cbdv) + Fluconazole

Fluconazole brand names: Diflucan, Diflucan Injection.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Cannabidivarin (cbdv) and Fluconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cannabidivarin (cbdv) and Fluconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fluconazole and Cannabidivarin (cbdv) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cannabidivarin (cbdv) at all — not against Fluconazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabidivarin (cbdv) safety at a glance

Cannabidivarin (cb... overall Not established Human safety data are very limited, so long-term effects are not well understood.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fluconazole and Cannabidivarin (cbdv)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Cannabidivarin (cbdv) and Fluconazole May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tremor or shakiness Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin has been associated with dizziness, somnolence, and headache. Ataxia, confusion, and dysarthria have been reported in one patient in a clinical trial who had been taking cannabidivarin 800 mg twice daily for 30 days. This patient also experienced other symptoms of intoxication, including arterial hypotension, nystagmus, diplopia, and elevated liver transaminases.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
    2. 110246. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

  • Drowsiness / Dizziness / Headache Additional detail

    Cannabidivarin (cbdv)

    “There is currently a limited amount of information on the tolerability and adverse effects of oral cannabidivarin.

    Most Common Adverse Effects:

    Orally: Abdominal pain, diarrhea, dizziness, headache, nausea, rash, somnolence.

    Serious Adverse Effects (Rare):

    Orally: Acute kidney failure and elevated liver transaminases at a dose of 800 mg twice daily.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in cluster headache.

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Nausea Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin has been associated with diarrhea, nausea, and abdominal pain. Drooling has been reported in one child with Rett syndrome.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
    2. 110246. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

  • A skin rash Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin 800 mg twice daily has been associated with maculopapular rash. The rash resolved with discontinuation of cannabidivarin.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

Reported for Cannabidivarin (cbdv) but not commonly for Fluconazole: kidney problems, low blood pressure, confusion and unsteadiness.

Effects for Fluconazole come from the ADVERSE REACTIONS section of its FDA label; effects for Cannabidivarin (cbdv) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Cannabidivarin (cbdv) or Fluconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cannabidivarin (cbdv) or Fluconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fluconazole

This page covers Cannabidivarin (cbdv) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fluconazole page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Adrafinil (moderate).

By severity: 4 major · 54 moderate · 23 minor.

From our pharmacist’s overview on the Fluconazole page

“Fluconazole (Diflucan) treats fungal infections, and I would pair it with supplements carefully. Nearly half of the 81 ingredients with an interaction on file, 38 of them, put extra strain on the liver, which is already busy processing the antifungal.”

Reviewed by 2 · Jul 18, 2026

Open the Fluconazole interaction page

How much people look this up

Where Cannabidivarin (cbdv) and Fluconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabidivarin (cbdv)
Steady interest

#1,249 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fluconazole
Top half

#941 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabidivarin (cbdv) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cannabidivarin (cbdv) and Fluconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cannabidivarin (cbdv)

What is Cannabidivarin (cbdv)?

  • Epilepsy and seizures
  • Autism spectrum disorder
  • Rett syndrome
  • Fragile X syndrome
  • Nausea
  • Anxiety

Cannabidivarin (CBDV) is a non-intoxicating compound found in cannabis that is being studied mainly for epilepsy and certain neurodevelopmental conditions. The research is still early, mostly from laboratory and animal studies plus small human trials, so it is not an approved or proven treatment. Talk to your pharmacist or doctor before trying any CBDV product.

Cannabaceae · Compound derived from the flowers and leaves of the cannabis plant · Oils, tinctures, isolates, and research-grade formulations

An interaction check asks whether these two react with each other — it does not ask whether Cannabidivarin (cbdv) is a good idea for someone in your situation. Here is what our Cannabidivarin (cbdv) record says about it on its own.

Cannabidivarin (cbdv): dosing

There is no established standard dose for CBDV. The amounts used in research studies were chosen for those specific trials and are not the same as general supplement guidance.If you choose to use a CBDV product, follow the directions on the product label and start low.

From our Cannabidivarin (cbdv) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabidivarin (cbdv) monograph & all interactions
Medication

About Fluconazole

What Is Fluconazole Used For?

Brand names: Diflucan, Diflucan Injection

Fluconazole treats infections caused by Candida and Cryptococcus fungi. Diflucan tablets and oral fluconazole tablets and suspension are approved to treat vaginal yeast infections (vaginal candidiasis), thrush in the mouth or throat (oropharyngeal candidiasis), and yeast infections of the esophagus. All forms — tablets, oral suspension, and injection — are used for cryptococcal meningitis (a serious fungal brain infection). In smaller studies, fluconazole has also shown effectiveness against Candida urinary tract infections, peritonitis (infection in the abdomen), and serious systemic (bloodstream and organ) Candida infections.

Fluconazole is also used to prevent candidiasis in people undergoing bone marrow transplants who receive chemotherapy or radiation therapy. Note that vaginal candidiasis is an approved use for the tablets and Diflucan oral products, but not for the injection or oral suspension alone.

Most-Reported Side Effects for Fluconazole

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 4,205 reports
Nausea 3,813 reports
Diarrhea 3,614 reports
Fatigue 3,266 reports
Headache 2,930 reports
See full Fluconazole drug information
Keep checking

Other Drugs & Cannabidivarin (cbdv)

Browse every other medication we’ve checked against Cannabidivarin (cbdv) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Cannabidivarin (cbdv) References

The 4 references that drive our Cannabidivarin (cbdv) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. European Medicines Agency. Public summary of opinion on orphan designation: Cannabidivarin for treatment of fragile X syndrome. Available at: https://www.ema.europa.eu/en/documents/orphan-designation/eu/3/18/1977-public-summary-opinion-orphan-designation-
  2. US Food and Drug Administration. Orphan Drug Designations and Approvals. Available at: https://www.accessdata.fda.gov/scripts/opdlisting/oopd/. Accessed on March 19, 2021.
  3. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
  4. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabidivarin (cbdv) and Fluconazole Together: Common Questions

Is it safe to take Cannabidivarin (cbdv) with Fluconazole?
We do not list a known interaction between Cannabidivarin (cbdv) and Fluconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cannabidivarin (cbdv) and Fluconazole have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Fluconazole interact with any supplements?
Yes. Fluconazole has documented interactions with 81 supplements in our database — Cannabidivarin (cbdv) is not one of them. The Fluconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Fluconazole and Cannabidivarin (cbdv)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.