Drug & supplement interaction

Cascarilla + Lioresal

Lioresal brand name: Lioresal Injection.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Cascarilla and Lioresal in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cascarilla and Lioresal

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lioresal and Cascarilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cascarilla at all — not against Lioresal, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cascarilla safety at a glance

Cascarilla overall Use caution Limited safety data exist, so use modest amounts and discuss with a healthcare professional first.
Pregnancy Avoid Not enough safety information is available, so avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lioresal and Cascarilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Lioresal’s Own FDA Label Lists

This is not an interaction — none of it involves Cascarilla. These are the most notable effects listed in the ADVERSE REACTIONS section of Lioresal’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • A stroke or mini-stroke Worth acting on
  • A bowel blockage Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • Trouble passing urine Worth acting on
  • Unsteadiness Worth acting on
  • A slow heartbeat Worth acting on
  • Blood clots Worth acting on

Showing the 10 most notable of 58 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Lioresal. Read the label on DailyMed › Cascarilla’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cascarilla side to compare — that is a limit of the record, not a statement that Cascarilla has no side effects.

From our Q&A

Questions About Cascarilla or Lioresal

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cascarilla or Lioresal, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lioresal

This page covers Cascarilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lioresal page lists 10 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Procaine (major), Biofeedback (moderate), Dendrobium (moderate), Ginkgo (moderate) and Lithium (moderate).

By severity: 1 major · 9 moderate.

From our pharmacist’s overview on the Lioresal page

“Lioresal is baclofen, a muscle relaxant prescribed for spasticity, and I would treat its supplement list with genuine care. Of the ten ingredients on file, six, including everyday picks like melatonin and ginkgo, may lower the seizure threshold, an added worry with a drug whose abrupt changes can already provoke seizures.”

Reviewed by 2 · Jul 18, 2026

Open the Lioresal interaction page

How much people look this up

Where Cascarilla and Lioresal Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cascarilla
Steady interest

#1,311 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lioresal
Top half

#1,029 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Cascarilla is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cascarilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Cascarilla and Lioresal records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cascarilla

What is Cascarilla?

  • Digestive upset and poor appetite
  • Bitter tonic for the stomach
  • Mild fever or chills (traditional)
  • Flavoring agent
  • Aromatic/incense use

Cascarilla is the aromatic, bitter bark of a Caribbean shrub (Croton eluteria) that has long been used as a digestive bitter and a flavoring. Modern scientific evidence for any health benefit is very limited, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Croton eluteria · Euphorbiaceae · Dried bark (and an essential oil distilled from it) · Tincture, bitters, tea, essential oil, and a flavoring in some liqueurs and tobacco products

An interaction check asks whether these two react with each other — it does not ask whether Cascarilla is a good idea for someone in your situation. Here is what our Cascarilla record says about it on its own.

Cascarilla: dosing

There is no well-established or standardized medicinal dose for cascarilla. Traditional use typically involves small amounts of bark steeped as a tea or a few drops of tincture used as a bitter.Because product strengths vary widely, the safest approach is to follow the directions on the product label and not exceed them.

From our Cascarilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cascarilla monograph & all interactions
Medication

About Baclofen

What Is Baclofen Used For?

Brand name: Lioresal Injection

Baclofen treats spasticity, which means stiff, tight muscles with spasms. Oral baclofen (tablets, Baclofen oral solution, Ozobax, Baclofen oral suspension, Fleqsuvy, Lyvispah) is used for spasticity from multiple sclerosis, especially flexor spasms with pain, clonus (rhythmic jerking) and muscle rigidity. It may also help some people with spinal cord injuries and other spinal cord diseases.

Intrathecal baclofen (Gablofen, Lioresal Intrathecal and other baclofen injections) is used for severe spasticity. It is given into the fluid around the spinal cord, usually through an implanted pump. It is not for skeletal muscle spasm from rheumatic disorders, and baclofen tablets are not recommended for stroke, cerebral palsy or Parkinson’s disease.

See full Baclofen drug information
Keep checking

Other Drugs & Cascarilla

Browse every other medication we’ve checked against Cascarilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cascarilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cascarilla list.

See the full Cascarilla interactions page
See every supplement checked against Lioresal, ranked by severity
Evidence & sources

Cascarilla References

The 3 sources that drive our Cascarilla monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Cascarilla is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Croton eluteria (Cascarilla) — U.S. National Library of Medicine, PubChem Source
  2. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  3. Herbs and Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cascarilla and Lioresal Together: Common Questions

Is it safe to take Cascarilla with Lioresal?
We do not list a known interaction between Cascarilla and Lioresal. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Lioresal interact with any supplements?
Yes. Lioresal has documented interactions with 10 supplements in our database — Cascarilla is not one of them. The Lioresal interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cascarilla monograph Uses, safety profile, and every drug interaction in one place Baclofen drug information The full plain-English guide to this medication Lioresal supplement interactions Every supplement checked against Lioresal, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lioresal and Cascarilla?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.