Drug & supplement interaction

Cat's Foot + Pentoxifylline

Pentoxifylline brand name: Trental.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cat's Foot and Pentoxifylline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pentoxifylline states a food rule worth keeping to.

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Interaction report

Cat's Foot and Pentoxifylline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pentoxifylline and Cat's Foot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cat's Foot at all — not against Pentoxifylline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cat's Foot safety at a glance

Cat's Foot overall Not established Very little human safety data exists, so caution is advised.
Pregnancy Avoid Not enough safety information; best to avoid during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pentoxifylline and Cat's Foot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Pentoxifylline’s Own FDA Label Lists

This is not an interaction — none of it involves Cat's Foot. These are the most notable effects listed in the ADVERSE REACTIONS section of Pentoxifylline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on mentioned in 9.4% of FDA reports for Pentoxifylline
  • Yellowing of the skin or eyes Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on
  • Anemia Worth acting on
  • A severe allergic reaction Worth acting on

Showing the 10 most notable of 39 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Pentoxifylline. Read the label on DailyMed › Where a percentage is shown, it is the share of 4,245 voluntary FDA FAERS reports for Pentoxifylline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Cat's Foot’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cat's Foot side to compare — that is a limit of the record, not a statement that Cat's Foot has no side effects.

How to take them

Some Pentoxifylline Products Have a Food Rule — Cat's Foot Should Not Break It

At least one FDA label for a product containing Pentoxifylline says to take it with food. If you take Cat's Foot on an empty stomach out of habit, keep them separate — and take Pentoxifylline with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pentoxifylline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The usual dosage of pentoxifylline in extended-release tablet form is one tablet (400 mg) three times a day with meals.

From the Dosage and Administration section of the FDA label we read for Pentoxifylline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Pentoxifylline

This page covers Cat's Foot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pentoxifylline page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Pentoxifylline page

“Pentoxifylline (Trental) improves blood flow in people with poor leg circulation partly by making platelets less sticky, so treat this list as one to read carefully rather than skim. Of the 218 supplements on file, 202 can also slow clotting, which means adding them stacks bleeding risk on bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Pentoxifylline interaction page

How much people look this up

Where Cat's Foot and Pentoxifylline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cat's Foot
Steady interest

#1,286 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pentoxifylline
Top half

#1,342 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Cat's Foot is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cat's Foot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cat's Foot and Pentoxifylline records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cat's Foot

What is Cat's Foot?

  • Cough and sore throat
  • Digestive upset
  • Gallbladder and liver complaints
  • Mild inflammation
  • Diarrhea

Cat's Foot (Antennaria dioica) is a small flowering plant from the daisy family used in traditional European herbal medicine, mostly as a tea for coughs and digestive complaints. There is very little modern scientific research on its safety or effectiveness, so its benefits remain unproven. Talk with a pharmacist or doctor before using it, and avoid it if you are pregnant or breastfeeding.

Antennaria dioica · Asteraceae · Flowers and aerial (above-ground) parts · Tea (infusion), dried herb, tincture, sometimes capsules

An interaction check asks whether these two react with each other — it does not ask whether Cat's Foot is a good idea for someone in your situation. Here is what our Cat's Foot record says about it on its own.

Cat's Foot: dosing

There is no established standard dose for Cat's Foot. It has not been studied enough to know what amount is safe or effective.If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Cat's Foot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cat's Foot monograph & all interactions
Medication

About Pentoxifylline

What Is Pentoxifylline Used For?

Brand name: Trental

Pentoxifylline Extended-Release Tablets are used to treat intermittent claudication — leg pain, cramping, or fatigue that happens during walking because narrowed arteries aren't delivering enough blood to the muscles. The underlying cause is chronic occlusive arterial disease, a condition where the arteries in the limbs become blocked or narrowed over time.

Pentoxifylline can help improve walking distance and reduce symptoms, but it is not a substitute for procedures that physically open or bypass blocked arteries when those treatments are needed.

Most-Reported Side Effects for Pentoxifylline

From FAERS, the FDA’s public side-effect reporting system (4,300 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 457 reports
Diarrhea 431 reports
Dyspnea 405 reports
Fall 376 reports
Dizziness 371 reports
See full Pentoxifylline drug information
Keep checking

Other Drugs & Cat's Foot

Browse every other medication we’ve checked against Cat's Foot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cat's Foot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cat's Foot list.

See the full Cat's Foot interactions page
See every supplement checked against Pentoxifylline, ranked by severity
Evidence & sources

Cat's Foot References

The 3 sources that drive our Cat's Foot monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Cat's Foot is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Using Dietary Supplements Wisely — NIH NCCIH Source
  2. Herbs at a Glance — NIH NCCIH Source
  3. Herbal Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cat's Foot and Pentoxifylline Together: Common Questions

Is it safe to take Cat's Foot with Pentoxifylline?
We do not list a known interaction between Cat's Foot and Pentoxifylline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Cat's Foot and Pentoxifylline at the same time of day?
At least one FDA label for a product containing Pentoxifylline says to take it with food. If you take Cat's Foot on an empty stomach out of habit, keep them separate and take Pentoxifylline with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Pentoxifylline products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Pentoxifylline interact with any supplements?
Yes. Pentoxifylline has documented interactions with 218 supplements in our database — Cat's Foot is not one of them. The Pentoxifylline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cat's Foot monograph Uses, safety profile, and every drug interaction in one place Pentoxifylline drug information The full plain-English guide to this medication Pentoxifylline supplement interactions Every supplement checked against Pentoxifylline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pentoxifylline and Cat's Foot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.