Drug & supplement interaction

Catuaba + Ethinyl Estradiol, Norethindrone

Ethinyl Estradiol, Norethindrone brand names: Femhrt, Loestrin 21, Ovcon 35 21, Ovcon 50 28, Necon 0.5 35 21, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Catuaba and Ethinyl Estradiol, Norethindrone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ethinyl Estradiol, Norethindrone states a food rule worth keeping to.

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Interaction report

Catuaba and Ethinyl Estradiol, Norethindrone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ethinyl Estradiol, Norethindrone and Catuaba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Catuaba at all — not against Ethinyl Estradiol, Norethindrone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Catuaba safety at a glance

Catuaba overall Not established Human safety data are very limited, so its long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data exist for nursing, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ethinyl Estradiol, Norethindrone and Catuaba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ethinyl Estradiol, Norethindrone’s Own FDA Label Lists

This is not an interaction — none of it involves Catuaba. These are the most notable effects listed in the ADVERSE REACTIONS section of Ethinyl Estradiol, Norethindrone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Raised blood pressure Worth acting on
  • Bleeding or bruising Worth acting on

From the ADVERSE REACTIONS section of the FDA label for Ethinyl Estradiol, Norethindrone. Read the label on DailyMed › Catuaba’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Catuaba side to compare — that is a limit of the record, not a statement that Catuaba has no side effects.

How to take them

Some Ethinyl Estradiol, Norethindrone Products Have a Food Rule — Catuaba Should Not Break It

At least one FDA label for a product containing Ethinyl Estradiol, Norethindrone says to take it with food. If you take Catuaba on an empty stomach out of habit, keep them separate — and take Ethinyl Estradiol, Norethindrone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ethinyl Estradiol, Norethindrone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Tablets should be taken regularly with a meal or at bedtime.

From the Dosage and Administration section of the FDA label we read for Ethinyl Estradiol, Norethindrone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ethinyl Estradiol, Norethindrone

This page covers Catuaba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ethinyl Estradiol, Norethindrone page lists 240 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 196 moderate · 38 minor.

From our pharmacist’s overview on the Ethinyl Estradiol, Norethindrone page

“If you take a birth control pill or hormone therapy containing ethinyl estradiol and norethindrone (Loestrin, Femhrt, and others), a few supplements can genuinely undermine it, so read this page with care. Six of the 240 ingredients on file are rated major, and those six come first.”

Reviewed by 2 · Jul 18, 2026

Open the Ethinyl Estradiol, Norethindrone interaction page

One more smart check

Taking Catuaba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 242 real supplement products containing Catuaba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Catuaba. Even though Catuaba itself has no known interaction with Ethinyl Estradiol, Norethindrone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Catuaba and Ethinyl Estradiol, Norethindrone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Catuaba
Top half

#493 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ethinyl Estradiol, Norethindrone
Top 25%

#450 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Catuaba and Ethinyl Estradiol, Norethindrone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Catuaba

What is Catuaba?

  • Low libido or sexual performance
  • Erectile difficulties
  • General energy and fatigue
  • Mood support
  • Aphrodisiac (traditional tonic)

Catuaba is a Brazilian herbal bark long used as a traditional aphrodisiac and energy tonic, but there is very little reliable human research to show it works for any health condition. Quality and contents of products vary widely, so talk with your pharmacist or doctor before trying it, and avoid it if you are pregnant or breastfeeding.

Bark (and sometimes stems) · Capsules, tea, liquid extracts and tinctures, powders, and as part of multi-herb blends

An interaction check asks whether these two react with each other — it does not ask whether Catuaba is a good idea for someone in your situation. Here is what our Catuaba record says about it on its own.

Catuaba: dosing

There is no established, standardized dose for catuaba. Because the species and strength of products vary, there is no reliable "correct" amount that research supports.If you choose to use catuaba, follow the directions on the product label and do not exceed the recommended amount. Starting low is sensible. A pharmacist can help you review the specific product you are considering and check whether it is a good fit for you.

From our Catuaba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Catuaba monograph & all interactions
Keep checking

Other Drugs & Catuaba

Browse every other medication we’ve checked against Catuaba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Catuaba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Catuaba list.

See the full Catuaba interactions page
See every supplement checked against Ethinyl Estradiol, Norethindrone, ranked by severity
Sources

Sources & How We Checked

We checked Catuaba against Ethinyl Estradiol, Norethindrone in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Catuaba monograph › Uses, safety, and every drug interaction in one place Ethinyl Estradiol, Norethindrone supplement interactions › Every supplement checked against Ethinyl Estradiol, Norethindrone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Catuaba and Ethinyl Estradiol, Norethindrone Together: Common Questions

Is it safe to take Catuaba with Ethinyl Estradiol, Norethindrone?
We do not list a known interaction between Catuaba and Ethinyl Estradiol, Norethindrone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Catuaba and Ethinyl Estradiol, Norethindrone at the same time of day?
At least one FDA label for a product containing Ethinyl Estradiol, Norethindrone says to take it with food. If you take Catuaba on an empty stomach out of habit, keep them separate and take Ethinyl Estradiol, Norethindrone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ethinyl Estradiol, Norethindrone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Ethinyl Estradiol, Norethindrone interact with any supplements?
Yes. Ethinyl Estradiol, Norethindrone has documented interactions with 240 supplements in our database — Catuaba is not one of them. The Ethinyl Estradiol, Norethindrone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ethinyl Estradiol, Norethindrone and Catuaba?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.