Drug & supplement interaction

Cha De Bugre + Sofosbuvir

Sofosbuvir brand name: Sovaldi.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Cha De Bugre and Sofosbuvir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cha De Bugre and Sofosbuvir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sofosbuvir and Cha De Bugre in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cha De Bugre at all — not against Sofosbuvir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cha De Bugre safety at a glance

Cha De Bugre overall Use caution Limited human safety data and possible stimulant effects mean it should be used cautiously.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sofosbuvir and Cha De Bugre? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Sofosbuvir’s Own FDA Label Lists

This is not an interaction — none of it involves Cha De Bugre. These are the most notable effects listed in the ADVERSE REACTIONS section of Sofosbuvir’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Anemia Worth acting on
  • Tiredness mentioned in 17.7% of FDA reports for Sofosbuvir
  • Trouble sleeping mentioned in 4.7% of FDA reports for Sofosbuvir
  • Reduced appetite
  • Headache mentioned in 14.7% of FDA reports for Sofosbuvir
  • Nausea mentioned in 7.5% of FDA reports for Sofosbuvir

From the ADVERSE REACTIONS section of the FDA label for Sofosbuvir. Read the label on DailyMed › Where a percentage is shown, it is the share of 52,253 voluntary FDA FAERS reports for Sofosbuvir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Cha De Bugre’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cha De Bugre side to compare — that is a limit of the record, not a statement that Cha De Bugre has no side effects.

Everything else you take

See Every Supplement That Interacts With Sofosbuvir

This page covers Cha De Bugre only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 37 moderate · 16 minor.

From our pharmacist’s overview on the Sofosbuvir page

“Sofosbuvir (Sovaldi) cures hepatitis C over a fixed course, so a supplement that lowers its blood level risks more than a side effect; it can let the virus survive treatment. The two major-rated interactions among the 55 ingredients here do exactly that: St.”

Reviewed by 2 · Jul 18, 2026

Open the Sofosbuvir interaction page

One more smart check

Taking Cha De Bugre as Part of a Dietary Supplement Product? Check It for Interactions

We hold 62 real supplement products containing Cha De Bugre, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cha De Bugre. Even though Cha De Bugre itself has no known interaction with Sofosbuvir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cha De Bugre and Sofosbuvir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cha De Bugre
Steady interest

#1,053 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sofosbuvir
Steady interest

#1,498 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cha De Bugre and Sofosbuvir records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cha De Bugre

What is Cha De Bugre?

  • Weight loss
  • Appetite control
  • Mild diuretic (water retention)
  • Cellulite
  • Energy and stimulation

Cha De Bugre is a Brazilian herbal tea traditionally used for weight loss and appetite control, but solid human research supporting these uses is lacking. Because it may have caffeine-like stimulant effects and its safety has not been well studied, talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Cordia salicifolia · Boraginaceae · Leaves · Tea, capsules, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Cha De Bugre is a good idea for someone in your situation. Here is what our Cha De Bugre record says about it on its own.

Cha De Bugre: dosing

There is no well-established or standardized dose for Cha De Bugre. The strength of teas, capsules, and extracts can vary widely from product to product.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.

From our Cha De Bugre monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cha De Bugre monograph & all interactions
Medication

About Sofosbuvir

What Is Sofosbuvir Used For?

Brand name: Sovaldi

Sovaldi (sofosbuvir) is used to treat chronic hepatitis C virus (HCV) infection. In adults, it treats genotype 1, 2, 3, or 4 HCV — with or without compensated cirrhosis (mild liver scarring that the liver is still managing). It is always used as part of a combination regimen with other antiviral medicines.

In children 3 years and older, Sovaldi is approved for genotype 2 or 3 HCV, with or without compensated cirrhosis, in combination with ribavirin. Sovaldi is also used with ribavirin in adults with HCV-related liver cancer (hepatocellular carcinoma) who are waiting for a liver transplant, to help prevent HCV from returning after transplant.

See full Sofosbuvir drug information
Keep checking

Other Drugs & Cha De Bugre

Browse every other medication we’ve checked against Cha De Bugre — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cha De Bugre against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cha De Bugre list.

See the full Cha De Bugre interactions page
See every supplement checked against Sofosbuvir, ranked by severity
Sources

Sources & How We Checked

We checked Cha De Bugre against Sofosbuvir in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cha De Bugre monograph › Uses, safety, and every drug interaction in one place Sofosbuvir supplement interactions › Every supplement checked against Sofosbuvir, ranked by severity Sofosbuvir drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cha De Bugre and Sofosbuvir Together: Common Questions

Is it safe to take Cha De Bugre with Sofosbuvir?
We do not list a known interaction between Cha De Bugre and Sofosbuvir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Sofosbuvir interact with any supplements?
Yes. Sofosbuvir has documented interactions with 55 supplements in our database — Cha De Bugre is not one of them. The Sofosbuvir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Sofosbuvir and Cha De Bugre?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.