Chickweed + Diphenhydramine, Zinc Oxide
Diphenhydramine, Zinc Oxide brand name: Caladryl Clear.
We found no known interaction between Chickweed and Diphenhydramine, Zinc Oxide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Chickweed and Diphenhydramine, Zinc Oxide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Diphenhydramine, Zinc Oxide and Chickweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Chickweed at all — not against Diphenhydramine, Zinc Oxide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Chickweed safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Chickweed in Pregnancy & Breastfeeding
When used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of chickweed when used orally in amounts greater than those found in food; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Diphenhydramine, Zinc Oxide
This page covers Chickweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine, Zinc Oxide page lists 6 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).
By severity: 5 moderate · 1 minor.
From our pharmacist’s overview on the Diphenhydramine, Zinc Oxide page
“Caladryl Clear, the diphenhydramine and zinc oxide lotion people dab on itchy bites and rashes, carries a short and manageable interaction list. None of its six flagged ingredients rates major; five are moderate and one minor.”
Reviewed by 2 · Jul 18, 2026
Taking Chickweed as Part of a Dietary Supplement Product? Check It for Interactions
We hold 272 real supplement products containing Chickweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chickweed. Even though Chickweed itself has no known interaction with Diphenhydramine, Zinc Oxide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Chickweed and Diphenhydramine, Zinc Oxide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#567 of 1,452 supplements looked up here in the last 7 days
#2,066 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chickweed reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chickweed and Diphenhydramine, Zinc Oxide records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Chickweed
What is Chickweed?
- Skin irritation and itching
- Minor wounds and cuts
- Digestive upset
- Joint and muscle aches
- Used historically for scurvy
- Mild diuretic
Chickweed is a common edible wild plant traditionally used on the skin for itching and minor irritation, and taken as a tea or tincture for various complaints. Solid human studies are lacking, so its benefits are largely based on tradition rather than proof. It is generally considered low-risk when used short-term, but pregnant and breastfeeding people should avoid it due to limited safety data.
Stellaria media · Caryophyllaceae · Above-ground parts (leaves, stems, and flowers) · Tea, capsules, tincture, dried herb, creams, ointments, salves, poultices
An interaction check asks whether these two react with each other — it does not ask whether Chickweed is a good idea for someone in your situation. Here is what our Chickweed record says about it on its own.
Chickweed: dosing
There is no established, standardized dose for chickweed. It is sold in many forms, including teas, tinctures, capsules, and skin creams or ointments, and the strength varies widely between products.If you use a commercial product, follow the directions on the label.
From our Chickweed monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Chickweed
Browse every other medication we’ve checked against Chickweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Chickweed against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chickweed list.
Chickweed References
The 4 references that drive our Chickweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
- Jovanovic, M., Poljacki, M., Mimica-Dukic, N., Boza, P., Vujanovic, Lj, Duran, V., and Stojanovic, S. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-alle
- Poljacki, M., Jovanovic, M., Boza, P., Mimica-Dukic, N., Petrovic, A., and Novovic, Z. [Is Vojvodina a risk area for contact weed allergies?]. Med Pregl. 2005;58(3-4):123-126. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Chickweed and Diphenhydramine, Zinc Oxide Together: Common Questions
Is it safe to take Chickweed with Diphenhydramine, Zinc Oxide?
Does Diphenhydramine, Zinc Oxide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.