Drug & supplement interaction

Clary Sage + Mefenamic Acid

Mefenamic Acid brand name: Ponstel.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Clary Sage and Mefenamic Acid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Clary Sage and Mefenamic Acid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mefenamic Acid and Clary Sage in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Clary Sage at all — not against Mefenamic Acid, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Clary Sage safety at a glance

Clary Sage overall Use caution Generally considered safe as a diluted essential oil for aromatherapy, but it should not be taken by mouth.
Pregnancy Avoid Often discouraged in pregnancy because it is traditionally linked to uterine activity, so avoid it.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mefenamic Acid and Clary Sage? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Mefenamic Acid’s Own FDA Label Lists

This is not an interaction — none of it involves Clary Sage. These are the most notable effects listed in the ADVERSE REACTIONS section of Mefenamic Acid’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on

Showing the 10 most notable of 55 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Mefenamic Acid. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,182 voluntary FDA FAERS reports for Mefenamic Acid that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Clary Sage’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Clary Sage side to compare — that is a limit of the record, not a statement that Clary Sage has no side effects.

Overlapping uses

What Mefenamic Acid Is Prescribed For, and What Clary Sage Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Mefenamic Acid is a prescription medicine with approved uses on its FDA label. Clary Sage is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Mefenamic Acid is prescribed for: Mefenamic acid capsules are approved to manage mild to moderate pain in adults and adolescents 14 years of age and older, but only for short-term use — no longer than 7 days. They are also approved to treat primary dysmenorrhea (painful menstrual periods), started at the onset of bleeding and associated symptoms.

Clary Sage has been studied for:

  • Dysmenorrhea studied, not established Clary Sage has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Clary Sage for dysmenorrhea

    Clinical research in young women with moderate to severe dysmenorrhea shows that use of an aromatic massage cream containing lavender, clary sage, and marjoram oils daily during a menstrual cycle modestly reduces pain. On the second and third days of the next cycle, pain was reduced by 45% to 60% compared with a reduction of 20% to 40% with a placebo cream containing a synthetic fragrance.

    1 source cited
    1. 58095. Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Mefenamic Acid on your own; if you are taking Clary Sage for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Mefenamic Acid

This page covers Clary Sage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mefenamic Acid page lists 118 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 86 moderate · 27 minor.

From our pharmacist’s overview on the Mefenamic Acid page

“Mefenamic acid (Ponstel), an NSAID mostly used for menstrual cramps and short-term pain, has a supplement list that earns genuine caution, and the five major-rated entries are where to start. Beer and wine are two of them, because alcohol plus any NSAID raises the risk of stomach and intestinal bleeding.”

Reviewed by 2 · Jul 18, 2026

Open the Mefenamic Acid interaction page

One more smart check

Taking Clary Sage as Part of a Dietary Supplement Product? Check It for Interactions

We hold 31 real supplement products containing Clary Sage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Clary Sage. Even though Clary Sage itself has no known interaction with Mefenamic Acid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Clary Sage and Mefenamic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clary Sage
Steady interest

#1,275 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mefenamic Acid
Top half

#1,348 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Clary Sage reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Clary Sage and Mefenamic Acid records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Clary Sage

What is Clary Sage?

  • Stress and anxiety
  • Menstrual cramps
  • Menopause symptoms
  • Aromatherapy and relaxation
  • Skin care

Clary sage is a Mediterranean herb most often used as an essential oil for aromatherapy and to ease stress or menstrual discomfort. Evidence for these uses is limited and mostly from small studies, and the oil should never be swallowed and should always be diluted before skin contact.

Salvia sclarea · Lamiaceae · Flowering tops and leaves (essential oil) · Essential oil, aromatherapy blends, diluted topical oils

An interaction check asks whether these two react with each other — it does not ask whether Clary Sage is a good idea for someone in your situation. Here is what our Clary Sage record says about it on its own.

Clary Sage: dosing

There is no official or standardized dose for clary sage, and it is not meant to be taken by mouth as a supplement.For aromatherapy, people typically add a few drops to a diffuser or dilute a small amount in a carrier oil before applying it to the skin.

From our Clary Sage monograph — the full record covers uses, side effects and every documented interaction.

Read the full Clary Sage monograph & all interactions
Medication

About Mefenamic Acid

What Is Mefenamic Acid Used For?

Brand name: Ponstel

Mefenamic acid capsules are approved to manage mild to moderate pain in adults and adolescents 14 years of age and older, but only for short-term use — no longer than 7 days.

They are also approved to treat primary dysmenorrhea (painful menstrual periods), started at the onset of bleeding and associated symptoms.

Most-Reported Side Effects for Mefenamic Acid

From FAERS, the FDA’s public side-effect reporting system (2,182 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 314 reports
Fatigue 264 reports
Headache 238 reports
Dizziness 189 reports
Malaise 177 reports
See full Mefenamic Acid drug information
Keep checking

Other Drugs & Clary Sage

Browse every other medication we’ve checked against Clary Sage — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Clary Sage against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Clary Sage list.

See the full Clary Sage interactions page
See every supplement checked against Mefenamic Acid, ranked by severity
Evidence & sources

Clary Sage References

The 2 references that drive our Clary Sage monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed
  2. Amirhosseini M, Dehghan M, Mangolian Shahrbabaki P, Pakmanesh H. Effectiveness of aromatherapy for relief of pain, nausea, and vomiting after percutaneous nephrolithotomy: a randomized controlled trial. Complement Med Res 2020:1-9. Online ahead of print. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Clary Sage and Mefenamic Acid Together: Common Questions

Is it safe to take Clary Sage with Mefenamic Acid?
We do not list a known interaction between Clary Sage and Mefenamic Acid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Clary Sage and Mefenamic Acid used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Clary Sage in each. That is a conversation for your prescriber, especially if Mefenamic Acid is being adjusted to a target.
Does Mefenamic Acid interact with any supplements?
Yes. Mefenamic Acid has documented interactions with 118 supplements in our database — Clary Sage is not one of them. The Mefenamic Acid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Clary Sage monograph Uses, safety profile, and every drug interaction in one place Mefenamic Acid drug information The full plain-English guide to this medication Mefenamic Acid supplement interactions Every supplement checked against Mefenamic Acid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mefenamic Acid and Clary Sage?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.