Drug & supplement interaction

Clown's Mustard Plant + Buspirone

Buspirone brand name: BuSpar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Clown's Mustard Plant and Buspirone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Clown's Mustard Plant and Buspirone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Buspirone and Clown's Mustard Plant in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Clown's Mustard Plant at all — not against Buspirone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Clown's Mustard Plant safety at a glance

Clown's Mustard Pl... overall Use caution Generally well tolerated as part of standardized combination products, but stand-alone safety data are limited.
Pregnancy Avoid Not enough safety information; it is best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Buspirone and Clown's Mustard Plant? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Clown's Mustard Plant and Buspirone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / A skin rash / Nausea Additional detail

    Clown's Mustard Plant

    “Orally, clown's mustard plant can cause nausea and diarrhea in some patients. Some patients might be hypersensitive to clown's mustard plant. There is one case of a facial rash following oral use.”

    Clown's Mustard Plant · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 7051. Steimer P. Iberogast therapy in gastroenterology. Der Krankenhaus Arzt 1983;56:1005-8.

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

Effects for Buspirone come from the ADVERSE REACTIONS section of its FDA label; effects for Clown's Mustard Plant come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Clown's Mustard Plant or Buspirone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Clown's Mustard Plant or Buspirone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Buspirone

This page covers Clown's Mustard Plant only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buspirone page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).

By severity: 4 major · 108 moderate · 43 minor.

From our pharmacist’s overview on the Buspirone page

“I counsel genuine caution when supplements meet buspirone (BuSpar), the anxiety medication, because four of its 155 documented interactions are rated major. The bulk of the list, 121 ingredients, changes how your liver clears buspirone through the CYP3A4 enzyme, pushing its level up toward dizziness and drowsiness or down until the anx…”

Reviewed by 2 · Jul 18, 2026

Open the Buspirone interaction page

One more smart check

Taking Clown's Mustard Plant as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Clown's Mustard Plant, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Clown's Mustard Plant. Even though Clown's Mustard Plant itself has no known interaction with Buspirone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Clown's Mustard Plant and Buspirone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clown's Mustard Plant
Steady interest

#1,235 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Buspirone
Top 5%

#53 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Clown's Mustard Plant reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Clown's Mustard Plant and Buspirone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Clown's Mustard Plant

What is Clown's Mustard Plant?

  • Indigestion (dyspepsia)
  • Bloating and stomach fullness
  • Irritable bowel syndrome (IBS) symptoms
  • Heartburn and stomach discomfort
  • Gas and cramping

Clown's Mustard Plant (Iberis amara) is a small flowering herb best known as one ingredient in a popular European multi-herb digestive formula used for indigestion and IBS. Most of the supportive evidence comes from studies of that combination product, not the herb by itself, so it is hard to know how well Clown's Mustard alone works. If you want to try it, talk with your pharmacist or doctor first, especially if you are pregnant, breastfeeding, or have ongoing stomach problems.

Iberis amara · Brassicaceae · Whole flowering plant (often used fresh or dried), including seeds · Liquid herbal extract (a key ingredient in multi-herb combination products), tincture

An interaction check asks whether these two react with each other — it does not ask whether Clown's Mustard Plant is a good idea for someone in your situation. Here is what our Clown's Mustard Plant record says about it on its own.

Clown's Mustard Plant: dosing

There is no well-established stand-alone dose for Clown's Mustard Plant. In practice, it is almost always taken as part of a standardized liquid combination product, where the dose is set by the manufacturer.If you use a product containing this herb, follow the directions on the label and do not exceed the recommended amount.

From our Clown's Mustard Plant monograph — the full record covers uses, side effects and every documented interaction.

Read the full Clown's Mustard Plant monograph & all interactions
Medication

About Buspirone

What Is Buspirone Used For?

Brand name: BuSpar

Buspirone is used to manage anxiety disorders and to relieve anxiety symptoms in the short term. Its effectiveness has been demonstrated in clinical trials for Generalized Anxiety Disorder (GAD) — persistent, hard-to-control worry and anxiety lasting at least a month, often accompanied by physical symptoms like muscle tension, restlessness, and a racing heart.

In clinical studies, buspirone also helped relieve anxiety in patients who had mild depressive symptoms alongside their anxiety. It is not a treatment for depression on its own, and it has no established antipsychotic activity.

See full Buspirone drug information
Keep checking

Other Drugs & Clown's Mustard Plant

Browse every other medication we’ve checked against Clown's Mustard Plant — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Clown's Mustard Plant against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Clown's Mustard Plant list.

See the full Clown's Mustard Plant interactions page
See every supplement checked against Buspirone, ranked by severity
Evidence & sources

Clown's Mustard Plant References

The 4 references that drive our Clown's Mustard Plant monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Holtmann G, Madisch A, Juergen H, et al. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Ann Mtg Digestive Disease Week 1999 May.
  2. Steimer P. Iberogast therapy in gastroenterology. Der Krankenhaus Arzt 1983;56:1005-8.
  3. Madisch A, Holtmann G, Mayr G, et al. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 2004;69:45-52. PubMed
  4. Melzer J, Rosch W, Reichling J, et al. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther 2004;20:1279-87. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Clown's Mustard Plant and Buspirone Together: Common Questions

Is it safe to take Clown's Mustard Plant with Buspirone?
We do not list a known interaction between Clown's Mustard Plant and Buspirone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Clown's Mustard Plant and Buspirone have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Buspirone interact with any supplements?
Yes. Buspirone has documented interactions with 155 supplements in our database — Clown's Mustard Plant is not one of them. The Buspirone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Clown's Mustard Plant monograph Uses, safety profile, and every drug interaction in one place Buspirone drug information The full plain-English guide to this medication Buspirone supplement interactions Every supplement checked against Buspirone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Buspirone and Clown's Mustard Plant?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.