Drug & supplement interaction

Coconut Oil + Abemaciclib

Abemaciclib brand name: Verzenio.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Coconut Oil and Abemaciclib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Coconut Oil and Abemaciclib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Abemaciclib and Coconut Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Coconut Oil at all — not against Abemaciclib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coconut Oil safety at a glance

Coconut Oil overall Use caution Generally safe as a food, but it is high in saturated fat, so heavy dietary use may affect cholesterol.

Pregnancy Use caution Normal food amounts are likely fine, but avoid large medicinal doses without medical advice.

Breastfeeding Use caution Normal food amounts are likely fine; talk to your doctor before using large amounts as a supplement.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Abemaciclib and Coconut Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

No Interaction Found — But Data Suggests Coconut Oil and Abemaciclib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

A heart attack Worth acting on Additional detail
Coconut Oil
“Due to its high saturated fat content, there has been some speculation that consuming coconut oil might increase cholesterol levels and the risk of cardiovascular disease. Several population and clinical studies have found that consuming coconut oil increases total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol in some patients.”

Coconut Oil · Natural Medicines adverse-effect record, reported in angina.
6 sources cited

12361. Reiser R, Probstfield JL, Silvers A, et al. Plasma lipid and lipoprotein response of humans to beef fat, coconut oil and safflower oil. Am J Clin Nutr 1985;42:190-7. PubMed

14407. Kumar PD. The role of coconut and coconut oil in coronary heart disease in Kerala, south India. Trop Doct 1997;27:215-7. PubMed

17935. Cox C, Sutherland W, Mann J, et al. Effects of dietary coconut oil, butter and safflower oil on plasma lipids, lipoproteins and lathosterol levels. Eur J Clin Nutr 1998;52:650-4. PubMed

17940. Feranil AB, Duazo PL, Kuzawa CW, Adair LS. Coconut oil is associated with a beneficial lipid profile in pre-menopausal women in the Philippines. Asia Pac J Clin Nutr 2011;20:190-5.

94451. Cox C, Mann J, Sutherland W, et al Effects of coconut oil, butter, and safflower oil on lipids and lipoproteins in persons with moderately elevated cholesterol levels. J Lipid Res 1995;36:1787-95. DOI

94452. Voon PT, Ng TK, Lee VK, Nesaretnam K. Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am J Cli PubMed
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
Stomach pain / Diarrhea Additional detail
Coconut Oil
“Orally, abdominal pain, diarrhea, and gastroenteritis have been reported rarely.”

Coconut Oil · Natural Medicines adverse-effect record, reported in diarrhea.
2 sources cited

101877. Neelakantan N, Seah JYH, van Dam RM. The effect of coconut oil consumption on cardiovascular risk factors: A systematic review and meta-analysis of clinical trials. Circulation. 2020;141(10):803-814. PubMed

115879. Alejandria MM, Dalmacio LMM, Climacosa FMM, et al. Virgin Coconut Oil as Adjunctive Therapy for Hospitalized COVID-19 Patients in a Tertiary Referral Hospital: A Randomized Controlled Trial. Acta Med Philipp 2024;58(8):31-41.
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›

Reported for Coconut Oil but not commonly for Abemaciclib: an allergic reaction, a severe allergic reaction, hives and swelling.

Effects for Abemaciclib come from the ADVERSE REACTIONS section of its FDA label; effects for Coconut Oil come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Abemaciclib Is Prescribed For, and What Coconut Oil Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Abemaciclib is a prescription medicine with approved uses on its FDA label. Coconut Oil is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Abemaciclib is prescribed for: Verzenio (abemaciclib) is used to treat HR-positive, HER2-negative breast cancer in adults. For early breast cancer at high risk of recurrence, Verzenio is taken alongside endocrine therapy (tamoxifen or an aromatase inhibitor) after surgery to help prevent the cancer from coming back. For advanced or metastatic breast cancer (cancer that has spread), Verzenio can be used in combination with an aromatase inhibitor as a first hormonal treatment, in combination with fulvestrant after the cancer has progressed on endocrine therapy, or alone after prior endocrine therapy and chemotherapy have stopped working.

Coconut Oil has been studied for:

Breast cancer studied, not established Coconut Oil has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Coconut Oil for breast cancer

It is unclear if oral coconut oil is beneficial in patients with breast cancer.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Abemaciclib on your own; if you are taking Coconut Oil for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Abemaciclib

This page covers Coconut Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Abemaciclib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Abemaciclib page

“A daily pill for a common form of advanced breast cancer, abemaciclib (Verzenio) only helps when its blood level stays steady, so this list of 138 supplements deserves genuine care. Nearly all of them act on CYP3A4, the liver enzyme that clears abemaciclib, meaning a supplement can push its level up and intensify side effects, or drag…”

Reviewed by 2 · Jul 18, 2026

Open the Abemaciclib interaction page

One more smart check

Taking Coconut Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 408 real supplement products containing Coconut Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coconut Oil. Even though Coconut Oil itself has no known interaction with Abemaciclib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coconut Oil and Abemaciclib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coconut Oil

Steady interest

#1,105 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Abemaciclib

Top 5%

#35 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coconut Oil reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Coconut Oil and Abemaciclib records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Coconut Oil

What is Coconut Oil?

Cooking and food preparation
Skin moisturizer
Hair conditioning
Oral health (oil pulling)
Weight management
Heart health (popularly claimed)

Coconut oil is a popular fat used in cooking, skin care, and hair care, and many people believe it has special health benefits. The evidence for most health claims is limited or mixed, and because coconut oil is very high in saturated fat, eating large amounts may raise LDL ('bad') cholesterol. Use it in moderation and talk to your pharmacist or doctor before using it for a specific health condition.

Cocos nucifera · Arecaceae · Oil extracted from the dried or fresh meat (kernel) of the coconut · Cooking oil (virgin and refined), capsules, skin and hair products, MCT oil derived from coconut

An interaction check asks whether these two react with each other — it does not ask whether Coconut Oil is a good idea for someone in your situation. Here is what our Coconut Oil record says about it on its own.

Coconut Oil: dosing

There is no official or standardized dose of coconut oil for any health condition. It is most often used simply as a cooking oil or food ingredient.Because it is high in saturated fat and calories, it is best used in moderation as part of a balanced diet. If you are using a coconut oil supplement or MCT product, follow the directions on the product label.For skin or hair use, a small amount applied to the area is typical.

From our Coconut Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coconut Oil monograph & all interactions

Medication

About Abemaciclib

What Is Abemaciclib Used For?

Brand name: Verzenio

Verzenio (abemaciclib) is used to treat HR-positive, HER2-negative breast cancer in adults. For early breast cancer at high risk of recurrence, Verzenio is taken alongside endocrine therapy (tamoxifen or an aromatase inhibitor) after surgery to help prevent the cancer from coming back.

For advanced or metastatic breast cancer (cancer that has spread), Verzenio can be used in combination with an aromatase inhibitor as a first hormonal treatment, in combination with fulvestrant after the cancer has progressed on endocrine therapy, or alone after prior endocrine therapy and chemotherapy have stopped working.

See full Abemaciclib drug information

Keep checking

Other Drugs & Coconut Oil

Browse every other medication we’ve checked against Coconut Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Coconut Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Coconut Oil list.

See the full Coconut Oil interactions page

See every supplement checked against Abemaciclib, ranked by severity

Evidence & sources

Coconut Oil References

The 20 references that drive our Coconut Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
Tella R, Gaig P, Lombardero M, et al. A case of coconut allergy. Allergy 2003;58:825-6. PubMed
Reiser R, Probstfield JL, Silvers A, et al. Plasma lipid and lipoprotein response of humans to beef fat, coconut oil and safflower oil. Am J Clin Nutr 1985;42:190-7. PubMed
Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3.
Kumar PD. The role of coconut and coconut oil in coronary heart disease in Kerala, south India. Trop Doct 1997;27:215-7. PubMed
Fries JH, Fries MW. Coconut: a review of its uses as they relate to the allergic individual. Ann Allergy 1983;51:472-81.
Cox C, Sutherland W, Mann J, et al. Effects of dietary coconut oil, butter and safflower oil on plasma lipids, lipoproteins and lathosterol levels. Eur J Clin Nutr 1998;52:650-4. PubMed
Feranil AB, Duazo PL, Kuzawa CW, Adair LS. Coconut oil is associated with a beneficial lipid profile in pre-menopausal women in the Philippines. Asia Pac J Clin Nutr 2011;20:190-5.
Cox C, Mann J, Sutherland W, et al Effects of coconut oil, butter, and safflower oil on lipids and lipoproteins in persons with moderately elevated cholesterol levels. J Lipid Res 1995;36:1787-95. DOI
Voon PT, Ng TK, Lee VK, Nesaretnam K. Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am J Cli PubMed
Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
Vijayakumar M, Vasudevan DM, Sundaram KR, et al. A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease. Indian Heart J. 2016 Jul-Aug;68(4):498-506. PubMed
Khaw KT, Sharp SJ, Finikarides L, et al. Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. BMJ Open. 2018;8(3):e020167. PubMed
Neelakantan N, Seah JYH, van Dam RM. The effect of coconut oil consumption on cardiovascular risk factors: A systematic review and meta-analysis of clinical trials. Circulation. 2020;141(10):803-814. PubMed
Teng M, Zhao YJ, Khoo AL, Yeo TC, Yong QW, Lim BP. Impact of coconut oil consumption on cardiovascular health: a systematic review and meta-analysis. Nutr Rev. 2020;78(3):249-259. PubMed
Jayawardena R, Swarnamali H, Lanerolle P, Ranasinghe P. Effect of coconut oil on cardio-metabolic risk: a systematic review and meta-analysis of interventional studies. Diabetes Metab Syndr 2020;14(6):2007-20. PubMed
Nikooei P, Hosseinzadeh-Attar MJ, Asghari S, Norouzy A, Yaseri M, Vasheghani-Farahani A. Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: a randomized controlled clinical trial. Nutr Metab Cardiov PubMed
Angeles-Agdeppa I, Nacis JS, Capanzana MV, Dayrit FM, Tanda KV. Virgin coconut oil is effective in lowering C-reactive protein levels among suspect and probable cases of COVID-19. J Funct Foods 2021;83:104557. PubMed
Alejandria MM, Dalmacio LMM, Climacosa FMM, et al. Virgin Coconut Oil as Adjunctive Therapy for Hospitalized COVID-19 Patients in a Tertiary Referral Hospital: A Randomized Controlled Trial. Acta Med Philipp 2024;58(8):31-41.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coconut Oil and Abemaciclib Together: Common Questions

Is it safe to take Coconut Oil with Abemaciclib?

We do not list a known interaction between Coconut Oil and Abemaciclib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Coconut Oil and Abemaciclib have any of the same side effects?

Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Coconut Oil and Abemaciclib used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Coconut Oil in each. That is a conversation for your prescriber, especially if Abemaciclib is being adjusted to a target.

Does Abemaciclib interact with any supplements?

Yes. Abemaciclib has documented interactions with 138 supplements in our database — Coconut Oil is not one of them. The Abemaciclib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coconut Oil monograph Uses, safety profile, and every drug interaction in one place Abemaciclib drug information The full plain-English guide to this medication Abemaciclib supplement interactions Every supplement checked against Abemaciclib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Abemaciclib and Coconut Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.