Drug & supplement interaction

Coconut Oil + Obinutuzumab

Obinutuzumab brand name: Gazyva.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Coconut Oil and Obinutuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Obinutuzumab states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Coconut Oil and Obinutuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Obinutuzumab and Coconut Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Coconut Oil at all — not against Obinutuzumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coconut Oil safety at a glance

Coconut Oil overall Use caution Generally safe as a food, but it is high in saturated fat, so heavy dietary use may affect cholesterol.
Pregnancy Use caution Normal food amounts are likely fine, but avoid large medicinal doses without medical advice.
Breastfeeding Use caution Normal food amounts are likely fine; talk to your doctor before using large amounts as a supplement.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Obinutuzumab and Coconut Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Coconut Oil and Obinutuzumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Coconut Oil

    “Several cases of allergic reactions have been reported for patients who consumed coconut fruit. In some of the cases, the patients were previously diagnosed with sensitivity to other tree nuts, including peanuts, so cross-sensitivity is suspected. In a separate case report, a 17-year-old male was found to be sensitized to both coconut and buckwheat, indicating a possible cross-sensitivity between the two allergens.”

    Coconut Oil · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    5 sources cited
    1. 95808. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
    2. 12359. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
    3. 12360. Tella R, Gaig P, Lombardero M, et al. A case of coconut allergy. Allergy 2003;58:825-6. PubMed
    4. 95806. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
    5. 14408. Fries JH, Fries MW. Coconut: a review of its uses as they relate to the allergic individual. Ann Allergy 1983;51:472-81.

    Obinutuzumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Obinutuzumab. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Coconut Oil

    “Orally, abdominal pain, diarrhea, and gastroenteritis have been reported rarely.”

    Coconut Oil · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 101877. Neelakantan N, Seah JYH, van Dam RM. The effect of coconut oil consumption on cardiovascular risk factors: A systematic review and meta-analysis of clinical trials. Circulation. 2020;141(10):803-814. PubMed
    2. 115879. Alejandria MM, Dalmacio LMM, Climacosa FMM, et al. Virgin Coconut Oil as Adjunctive Therapy for Hospitalized COVID-19 Patients in a Tertiary Referral Hospital: A Randomized Controlled Trial. Acta Med Philipp 2024;58(8):31-41.

    Obinutuzumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Obinutuzumab. Read the label on DailyMed ›

Reported for Coconut Oil but not commonly for Obinutuzumab: a heart attack, stomach pain, a severe allergic reaction and hives.

Effects for Obinutuzumab come from the ADVERSE REACTIONS section of its FDA label; effects for Coconut Oil come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Obinutuzumab Products Have a Food Rule — Coconut Oil Should Not Break It

At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach. Most supplements — Coconut Oil included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Obinutuzumab on its own and move Coconut Oil to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Obinutuzumab products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

650–1,000 mg acetaminophen At least 30 minutes before GAZYVA infusion.

From the Dosage and Administration section of the FDA label we read for Obinutuzumab — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

One more smart check

Taking Coconut Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 408 real supplement products containing Coconut Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coconut Oil. Even though Coconut Oil itself has no known interaction with Obinutuzumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coconut Oil and Obinutuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coconut Oil
Steady interest

#932 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Obinutuzumab
Steady interest

#1,744 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coconut Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Coconut Oil and Obinutuzumab records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coconut Oil

What is Coconut Oil?

  • Cooking and food preparation
  • Skin moisturizer
  • Hair conditioning
  • Oral health (oil pulling)
  • Weight management
  • Heart health (popularly claimed)

Coconut oil is a popular fat used in cooking, skin care, and hair care, and many people believe it has special health benefits. The evidence for most health claims is limited or mixed, and because coconut oil is very high in saturated fat, eating large amounts may raise LDL ('bad') cholesterol. Use it in moderation and talk to your pharmacist or doctor before using it for a specific health condition.

Cocos nucifera · Arecaceae · Oil extracted from the dried or fresh meat (kernel) of the coconut · Cooking oil (virgin and refined), capsules, skin and hair products, MCT oil derived from coconut

An interaction check asks whether these two react with each other — it does not ask whether Coconut Oil is a good idea for someone in your situation. Here is what our Coconut Oil record says about it on its own.

Coconut Oil: dosing

There is no official or standardized dose of coconut oil for any health condition. It is most often used simply as a cooking oil or food ingredient.Because it is high in saturated fat and calories, it is best used in moderation as part of a balanced diet. If you are using a coconut oil supplement or MCT product, follow the directions on the product label.For skin or hair use, a small amount applied to the area is typical.

From our Coconut Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coconut Oil monograph & all interactions
Medication

About Obinutuzumab Injection

What Is Obinutuzumab Injection Used For?

Brand name: Gazyva

Gazyva is used to treat three conditions. For chronic lymphocytic leukemia (CLL), it is given in combination with chlorambucil in patients who have not been treated before. For follicular lymphoma (FL), it is used either with bendamustine (for patients whose disease came back or stopped responding to a rituximab-based regimen) or with chemotherapy (for previously untreated advanced disease) — in both cases followed by Gazyva alone as maintenance therapy.

Gazyva is also approved for active lupus nephritis — a type of kidney inflammation caused by lupus — in adults who are already receiving standard therapy for the condition.

See full Obinutuzumab Injection drug information
Keep checking

Other Drugs & Coconut Oil

Browse every other medication we’ve checked against Coconut Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Coconut Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Coconut Oil list.

See the full Coconut Oil interactions page
See every supplement checked against Obinutuzumab, ranked by severity
Evidence & sources

Coconut Oil References

The 20 references that drive our Coconut Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Tella R, Gaig P, Lombardero M, et al. A case of coconut allergy. Allergy 2003;58:825-6. PubMed
  3. Reiser R, Probstfield JL, Silvers A, et al. Plasma lipid and lipoprotein response of humans to beef fat, coconut oil and safflower oil. Am J Clin Nutr 1985;42:190-7. PubMed
  4. Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3.
  5. Kumar PD. The role of coconut and coconut oil in coronary heart disease in Kerala, south India. Trop Doct 1997;27:215-7. PubMed
  6. Fries JH, Fries MW. Coconut: a review of its uses as they relate to the allergic individual. Ann Allergy 1983;51:472-81.
  7. Cox C, Sutherland W, Mann J, et al. Effects of dietary coconut oil, butter and safflower oil on plasma lipids, lipoproteins and lathosterol levels. Eur J Clin Nutr 1998;52:650-4. PubMed
  8. Feranil AB, Duazo PL, Kuzawa CW, Adair LS. Coconut oil is associated with a beneficial lipid profile in pre-menopausal women in the Philippines. Asia Pac J Clin Nutr 2011;20:190-5.
  9. Cox C, Mann J, Sutherland W, et al Effects of coconut oil, butter, and safflower oil on lipids and lipoproteins in persons with moderately elevated cholesterol levels. J Lipid Res 1995;36:1787-95. DOI
  10. Voon PT, Ng TK, Lee VK, Nesaretnam K. Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am J Cli PubMed
  11. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  12. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  13. Vijayakumar M, Vasudevan DM, Sundaram KR, et al. A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease. Indian Heart J. 2016 Jul-Aug;68(4):498-506. PubMed
  14. Khaw KT, Sharp SJ, Finikarides L, et al. Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. BMJ Open. 2018;8(3):e020167. PubMed
  15. Neelakantan N, Seah JYH, van Dam RM. The effect of coconut oil consumption on cardiovascular risk factors: A systematic review and meta-analysis of clinical trials. Circulation. 2020;141(10):803-814. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coconut Oil and Obinutuzumab Together: Common Questions

Is it safe to take Coconut Oil with Obinutuzumab?
We do not list a known interaction between Coconut Oil and Obinutuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Coconut Oil and Obinutuzumab have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Coconut Oil and Obinutuzumab at the same time of day?
At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Obinutuzumab on its own and move Coconut Oil to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coconut Oil monograph Uses, safety profile, and every drug interaction in one place Obinutuzumab Injection drug information The full plain-English guide to this medication Obinutuzumab supplement interactions Every supplement checked against Obinutuzumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Obinutuzumab and Coconut Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.