Drug & supplement interaction

Columbine + Alitretinoin

Alitretinoin brand name: Panretin.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Columbine and Alitretinoin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Columbine and Alitretinoin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alitretinoin and Columbine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Columbine at all — not against Alitretinoin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Columbine safety at a glance

Columbine overall Avoid Parts of the plant—especially seeds and roots—can be toxic, and safe use is not established.
Pregnancy Avoid Not enough safety data and potential toxicity make use during pregnancy unsafe.
Breastfeeding Avoid Safety has not been studied, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alitretinoin and Columbine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Alitretinoin’s Own FDA Label Lists

This is not an interaction — none of it involves Columbine. These are the most notable effects listed in the ADVERSE REACTIONS section of Alitretinoin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both.

  • Sun sensitivity
  • Numbness or tingling
  • Itching
  • Swelling
  • A skin rash

From the ADVERSE REACTIONS section of the FDA label for Alitretinoin. Read the label on DailyMed › Where a percentage is shown, it is the share of 117 voluntary FDA FAERS reports for Alitretinoin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Columbine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Columbine side to compare — that is a limit of the record, not a statement that Columbine has no side effects.

Everything else you take

See Every Supplement That Interacts With Alitretinoin

This page covers Columbine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alitretinoin page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Vitamin A (major), Alfalfa (moderate), Angelica Archangelica (moderate) and Arrach (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Alitretinoin page

“Alitretinoin (Panretin) is a retinoid gel used on Kaposi sarcoma skin lesions, and because it is a vitamin A derivative, treat these 38 supplement interactions with genuine care. Two carry a major rating.”

Reviewed by 2 · Jul 18, 2026

Open the Alitretinoin interaction page

One more smart check

Taking Columbine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Columbine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Columbine. Even though Columbine itself has no known interaction with Alitretinoin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Columbine and Alitretinoin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Columbine
Steady interest

#1,033 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alitretinoin
Steady interest

#1,453 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Columbine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Columbine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Columbine and Alitretinoin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Columbine

What is Columbine?

  • Skin sores and rashes (traditional)
  • Sore throat and mouth irritation (traditional)
  • Minor wounds (traditional, topical)
  • General folk remedy

Columbine is a flowering plant once used in traditional folk medicine, but there is very little modern scientific evidence that it works for any health condition. It belongs to the buttercup family, which contains potentially toxic compounds, so it is not recommended as a supplement and the seeds and roots in particular can be poisonous. If you are considering any herbal product, talk with your pharmacist or doctor first.

Aquilegia vulgaris · Ranunculaceae · Flowers, leaves, and root (used historically) · Rarely used today; historically prepared as teas, poultices, or tinctures

An interaction check asks whether these two react with each other — it does not ask whether Columbine is a good idea for someone in your situation. Here is what our Columbine record says about it on its own.

Columbine: dosing

There is no established or recommended dose for columbine. It is not a standard supplement, and safe amounts have not been determined through scientific study.Because of its potential toxicity, we do not recommend taking columbine. If you come across a product that contains it, follow the product label only after checking with a pharmacist or doctor, and do not exceed any directions given.

From our Columbine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Columbine monograph & all interactions
Medication

About Alitretinoin

What Is Alitretinoin Used For?

Brand name: Panretin

Panretin Gel is approved to treat cutaneous lesions — visible skin sores — in adults who have AIDS-related Kaposi's sarcoma (KS), a cancer that causes abnormal tissue to grow in the skin.

Panretin Gel is applied directly to the affected skin spots. It is not for use when the disease has spread widely enough to need systemic (whole-body) treatment — for example, when there are more than 10 new lesions in a month, or when the lungs, lymph nodes, or internal organs are involved.

Most-Reported Side Effects for Alitretinoin

From FAERS, the FDA’s public side-effect reporting system (117 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug intolerance 9 reports
Headache 9 reports
Hypercholesterolaemia 8 reports
Treatment failure 8 reports
Vomiting 8 reports
See full Alitretinoin drug information
Keep checking

Other Drugs & Columbine

Browse every other medication we’ve checked against Columbine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Columbine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Columbine list.

See the full Columbine interactions page
See every supplement checked against Alitretinoin, ranked by severity
Evidence & sources

Columbine References

The 1 sources that drive our Columbine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Columbine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Poisonous Plants — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Columbine and Alitretinoin Together: Common Questions

Is it safe to take Columbine with Alitretinoin?
We do not list a known interaction between Columbine and Alitretinoin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Alitretinoin interact with any supplements?
Yes. Alitretinoin has documented interactions with 38 supplements in our database — Columbine is not one of them. The Alitretinoin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Columbine monograph Uses, safety profile, and every drug interaction in one place Alitretinoin drug information The full plain-English guide to this medication Alitretinoin supplement interactions Every supplement checked against Alitretinoin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alitretinoin and Columbine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.