Columbine + Azacitidine
Azacitidine brand names: Vidaza, Onureg.
We found no known interaction between Columbine and Azacitidine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Columbine and Azacitidine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Azacitidine and Columbine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Columbine at all — not against Azacitidine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Columbine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Azacitidine
This page covers Columbine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Azacitidine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Azacitidine page
“Azacitidine treats myelodysplastic syndromes and certain leukemias, and if you take the oral form (Onureg), every one of the 17 supplements on this page can change how much of the medicine actually reaches your blood. With a cancer drug, an underdosed pill can mean less control of the disease, so treat this list with genuine care.”
Reviewed by 2 · Jul 18, 2026
Taking Columbine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 6 real supplement products containing Columbine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Columbine. Even though Columbine itself has no known interaction with Azacitidine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Columbine and Azacitidine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,040 of 1,452 supplements looked up here in the last 7 days
#2,202 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Columbine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Columbine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Columbine and Azacitidine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Columbine
What is Columbine?
- Skin sores and rashes (traditional)
- Sore throat and mouth irritation (traditional)
- Minor wounds (traditional, topical)
- General folk remedy
Columbine is a flowering plant once used in traditional folk medicine, but there is very little modern scientific evidence that it works for any health condition. It belongs to the buttercup family, which contains potentially toxic compounds, so it is not recommended as a supplement and the seeds and roots in particular can be poisonous. If you are considering any herbal product, talk with your pharmacist or doctor first.
Aquilegia vulgaris · Ranunculaceae · Flowers, leaves, and root (used historically) · Rarely used today; historically prepared as teas, poultices, or tinctures
An interaction check asks whether these two react with each other — it does not ask whether Columbine is a good idea for someone in your situation. Here is what our Columbine record says about it on its own.
Columbine: dosing
There is no established or recommended dose for columbine. It is not a standard supplement, and safe amounts have not been determined through scientific study.Because of its potential toxicity, we do not recommend taking columbine. If you come across a product that contains it, follow the product label only after checking with a pharmacist or doctor, and do not exceed any directions given.
From our Columbine monograph — the full record covers uses, side effects and every documented interaction.
About Azacitidine
What Is Azacitidine Used For?
Brand names: Vidaza, Onureg
Azacitidine injection (brands: Vidaza and generic azacitidine for injection) treats adults with myelodysplastic syndromes (MDS) — a group of bone marrow conditions where blood cells don't develop normally. The specific MDS subtypes include refractory anemia, refractory anemia with ringed sideroblasts (when accompanied by low white or platelet counts, or transfusion dependence), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia. Vidaza is also approved for infants and children aged 1 month and older with newly diagnosed juvenile myelomonocytic leukemia (JMML).
Onureg (the oral tablet form of azacitidine) is used for a different purpose: continued treatment of adults with acute myeloid leukemia (AML) who achieved their first remission after intensive chemotherapy but are not able to continue intensive curative therapy. Onureg is not interchangeable with the injectable forms.
Other Drugs & Columbine
Browse every other medication we’ve checked against Columbine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Columbine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amitriptyline ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Columbine list.
Columbine References
The 1 sources that drive our Columbine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Columbine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Poisonous Plants — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Columbine and Azacitidine Together: Common Questions
Is it safe to take Columbine with Azacitidine?
Does Azacitidine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Azacitidine and Columbine?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.