Columbine + Maprotiline
Maprotiline brand name: Ludiomil.
We found no known interaction between Columbine and Maprotiline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Columbine and Maprotiline
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Maprotiline and Columbine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Columbine at all — not against Maprotiline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Columbine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Maprotiline
This page covers Columbine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Maprotiline page lists 116 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Lithium (major), 1,3-dmaa (moderate), 5-htp (moderate) and Acacia Rigidula (moderate).
By severity: 2 major · 90 moderate · 24 minor.
From our pharmacist’s overview on the Maprotiline page
“The riskiest pairing on this page belongs to lithium. Taken alongside a serotonergic antidepressant like maprotiline (Ludiomil), it can both mask and raise the odds of serotonin syndrome, a dangerous buildup of serotonin activity, and it earns one of the list's two major ratings for that reason.”
Reviewed by 2 · Jul 18, 2026
Taking Columbine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 6 real supplement products containing Columbine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Columbine. Even though Columbine itself has no known interaction with Maprotiline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Columbine and Maprotiline Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,034 of 1,452 supplements looked up here in the last 7 days
#2,294 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Columbine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Columbine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Columbine and Maprotiline records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Columbine
What is Columbine?
- Skin sores and rashes (traditional)
- Sore throat and mouth irritation (traditional)
- Minor wounds (traditional, topical)
- General folk remedy
Columbine is a flowering plant once used in traditional folk medicine, but there is very little modern scientific evidence that it works for any health condition. It belongs to the buttercup family, which contains potentially toxic compounds, so it is not recommended as a supplement and the seeds and roots in particular can be poisonous. If you are considering any herbal product, talk with your pharmacist or doctor first.
Aquilegia vulgaris · Ranunculaceae · Flowers, leaves, and root (used historically) · Rarely used today; historically prepared as teas, poultices, or tinctures
An interaction check asks whether these two react with each other — it does not ask whether Columbine is a good idea for someone in your situation. Here is what our Columbine record says about it on its own.
Columbine: dosing
There is no established or recommended dose for columbine. It is not a standard supplement, and safe amounts have not been determined through scientific study.Because of its potential toxicity, we do not recommend taking columbine. If you come across a product that contains it, follow the product label only after checking with a pharmacist or doctor, and do not exceed any directions given.
From our Columbine monograph — the full record covers uses, side effects and every documented interaction.
About Maprotiline
What Is Maprotiline Used For?
Brand name: Ludiomil
-
Maprotiline is used to treat depression, bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods), and anxiety. Maprotiline is in a class of medications called tetracyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.
Other Drugs & Columbine
Browse every other medication we’ve checked against Columbine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Columbine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Columbine list.
Columbine References
The 1 sources that drive our Columbine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Columbine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Poisonous Plants — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Maprotiline Is Linked to Lower Levels of One Nutrient
Natural Medicines records Maprotiline as a medicine that can lower these. This is not an interaction with Columbine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Maprotiline nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Columbine and Maprotiline Together: Common Questions
Is it safe to take Columbine with Maprotiline?
Does Maprotiline interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Maprotiline and Columbine?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.