Drug & supplement interaction

Craniosacral Therapy + Promethazine

Promethazine brand name: Phenergan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Craniosacral Therapy and Promethazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Craniosacral Therapy and Promethazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Promethazine and Craniosacral Therapy in our sources. This does not guarantee that the combination is completely free of risk — research on Craniosacral Therapy alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Craniosacral Therapy at all — not against Promethazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Craniosacral Therapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Craniosacral Therapy safety at a glance

Craniosacral Thera... overall Use caution Generally low-risk when done by a trained practitioner, but it should not replace proven medical care.
Pregnancy Possibly Safe When used appropriately by trained practitioners. Craniosacral therapy has been used with apparent safety in clinical trials involving pregnant women for up to... Read the full pregnancy detail
Breastfeeding Use caution No known direct harm, but evidence is lacking; check with your healthcare provider.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Promethazine and Craniosacral Therapy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Promethazine’s Own FDA Label Lists

This is not an interaction — none of it involves Craniosacral Therapy. These are the most notable effects listed in the ADVERSE REACTIONS section of Promethazine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you have Craniosacral Therapy and take the medicine. 10 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Hallucinations Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Wheezing Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • A low platelet count Worth acting on
  • Hives Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on

Showing the 10 most notable of 26 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Promethazine. Read the label on DailyMed › Where a percentage is shown, it is the share of 22,361 voluntary FDA FAERS reports for Promethazine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Craniosacral Therapy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Craniosacral Therapy side to compare — that is a limit of the record, not a statement that Craniosacral Therapy has no side effects.

Special populations

Craniosacral Therapy in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used appropriately by trained practitioners. Craniosacral therapy has been used with apparent safety in clinical trials involving pregnant women for up to 8 weeks.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Craniosacral Therapy or Promethazine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Craniosacral Therapy or Promethazine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Promethazine

This page covers Craniosacral Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Promethazine page lists 83 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Alfalfa (moderate) and Angel's Trumpet (moderate).

By severity: 3 major · 57 moderate · 23 minor.

From our pharmacist’s overview on the Promethazine page

“Promethazine (Phenergan) is a phenothiazine antihistamine used for allergies, nausea, and motion sickness, and it is strongly anticholinergic on its own, causing dry mouth, blurred vision, drowsiness, and constipation. That is why the 83 supplements and herbs on this list deserve real attention, starting with the three rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Promethazine interaction page

How much people look this up

Where Craniosacral Therapy and Promethazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Craniosacral Therapy
Steady interest

#1,223 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Promethazine
Top half

#1,330 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Craniosacral Therapy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Craniosacral Therapy and Promethazine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Craniosacral Therapy

What is Craniosacral Therapy?

  • Headaches and migraines
  • Neck and back pain
  • Stress and tension relief
  • TMJ (jaw) discomfort
  • General relaxation and well-being

Craniosacral therapy is a gentle, hands-on bodywork technique that uses very light touch on the head, spine, and pelvis. It is generally low-risk and may help some people feel relaxed, but high-quality evidence that it treats specific medical conditions is limited and weak. Talk with your doctor before using it in place of proven care.

Not applicable (this is a hands-on therapy, not a plant or supplement) · Hands-on manual therapy sessions performed by a trained practitioner

An interaction check asks whether these two react with each other — it does not ask whether Craniosacral Therapy is a good idea for someone in your situation. Here is what our Craniosacral Therapy record says about it on its own.

Craniosacral Therapy: dosing

There is no standardized "dose" for craniosacral therapy because it is a hands-on service, not a product you swallow. Session length and how many sessions are recommended vary by practitioner and the reason for the visit.If you decide to try CST, choose a licensed and trained practitioner, ask about their qualifications, and discuss your goals and any health conditions first.

From our Craniosacral Therapy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Craniosacral Therapy monograph & all interactions
Medication

About Promethazine

What Is Promethazine Used For?

Brand name: Phenergan

Promethazine is used for a wide range of conditions. Tablets, oral solution, and rectal suppositories (brands including Phenergan, Promethegan, and Phenadoz) are approved for seasonal and perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, hives (urticaria), angioedema, dermographism, and allergic reactions to blood or plasma. They are also used for motion sickness (both prevention and active treatment), nausea and vomiting related to anesthesia and surgery, sedation, and as a helper medication alongside pain relievers after surgery.

Promethazine hydrochloride injection (brands including Phenergan and Promethazine HCl injection) is used for many of the same purposes but is reserved for situations where oral treatment is not possible — including allergic emergencies as an adjunct to epinephrine, sedation during labor, and as an aid during certain surgical procedures such as bronchoscopy and eye surgery.

Most-Reported Side Effects for Promethazine

From FAERS, the FDA’s public side-effect reporting system (22,614 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dependence 3,586 reports
Nausea 2,646 reports
Vomiting 1,802 reports
Fatigue 1,496 reports
Diarrhea 1,341 reports
See full Promethazine drug information
Keep checking

Other Drugs & Craniosacral Therapy

Browse every other medication we’ve checked against Craniosacral Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Craniosacral Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Craniosacral Therapy list.

See the full Craniosacral Therapy interactions page
See every supplement checked against Promethazine, ranked by severity
Evidence & sources

Craniosacral Therapy References

The 6 references that drive our Craniosacral Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Castro-Sánchez AM, Lara-Palomo IC, Matarán-Peñarrocha GA, Saavedra-Hernández M, Pérez-Mármol JM, Aguilar-Ferrándiz ME. Benefits of Craniosacral Therapy in Patients with Chronic Low Back Pain: A Randomized C
  2. Castro-Sánchez AM, Matarán-Peñarrocha GA, Sánchez-Labraca N, Quesada-Rubio JM, Granero-Molina J, Moreno-Lorenzo C. A randomized controlled trial investigating the effects of craniosacral therapy on pain and heart rate variabili
  3. Elden H, Östgaard HC, Glantz A, Marciniak P, Linnér AC, Olsén MF. Effects of craniosacral therapy as adjunct to standard treatment for pelvic girdle pain in pregnant women: a multicenter, single blind, randomized controlled trial. Acta PubMed
  4. Haller H, Lauche R, Cramer H, et al. Craniosacral Therapy for the Treatment of Chronic Neck Pain: A Randomized Sham-controlled Trial. Clin J Pain. 2016;32(5):441-9. PubMed
  5. Atay F, Bayramlar K, Sarac ET. Effects of Craniosacral Osteopathy in Patients with Peripheral Vestibular Pathology. ORL J Otorhinolaryngol Relat Spec. 2020:1-7. PubMed
  6. Castejón-Castejón M, Murcia-González MA, Martínez Gil JL, Todri J, Suárez Rancel M, Lena O, Chillón-Martínez R. Effectiveness of craniosacral therapy in the treatment of infantile colic. A randomized controlled trial. Complement Ther Med. 2019;47:102164. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Craniosacral Therapy While Taking Promethazine: Common Questions

Is it safe to have Craniosacral Therapy while taking Promethazine?
We do not list a known interaction between Craniosacral Therapy and Promethazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Promethazine interact with any supplements?
Yes. Promethazine has documented interactions with 83 supplements in our database — Craniosacral Therapy is not one of them. The Promethazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Craniosacral Therapy monograph Uses, safety profile, and every drug interaction in one place Promethazine drug information The full plain-English guide to this medication Promethazine supplement interactions Every supplement checked against Promethazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Promethazine and Craniosacral Therapy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.