Drug & supplement interaction

Cypress + Gemcitabine

Gemcitabine brand name: Gemzar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cypress and Gemcitabine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cypress and Gemcitabine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Gemcitabine and Cypress in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cypress safety at a glance

Cypress overall Use caution Often used externally or in aromatherapy; the essential oil should not be swallowed and human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information, so it is best to avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Gemcitabine and Cypress? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Gemcitabine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Gemcitabine is filed under 2 classifications — antineoplastics, hepatotoxic drugs. Cypress has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Gemcitabine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cypress Does Interact With Other Medications

Cypress has 122 moderate known drug interactions in our database — Gemcitabine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Gemcitabine)
Taking anything else?

Check Another of Your Medications Against Cypress

Covers the 2,830 medications we’ve checked against Cypress. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cypress and Gemcitabine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Cypress

    “Airborne cypress pollen is a common cause of allergy-related respiratory and ocular symptoms in some people. A case of allergic contact dermatitis to the resin-impregnated leaves of a cypress tree has occurred in a patient with a history of cutaneous reactions to adhesive bandages, likely due to a cross-sensitivity with colophonium.”

    Cypress · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    5 sources cited
    1. 46912. Geller-Bernstein, C., Waisel, Y., and Lahoz, C. Environment and sensitization to cypress in Israel. Allerg.Immunol.(Paris) 2000;32(3):92-93.
    2. 46915. Papa, G., Romano, A., Quaratino, D., Di Fonso, M., Viola, M., Artesani, M. C., Sernia, S., Di Gioacchino, M., and Venuti, A. Prevalence of sensitization to Cupressus sempervirens: a 4-year retrospective study. Sci.Total Environ. 4-10-2001;270(1-3):83-87. PubMed
    3. 46925. Togawa, A., Panzani, R. C., Garza, M. A., Kishikawa, R., Goldblum, R. M., and Midoro-Horiuti, T. Identification of italian cypress (Cupressus sempervirens) pollen allergen Cup s 3 using homology and cross-reactivity. Ann.Allergy Asthma Immunol. 2006;97(3 PubMed
    4. 46930. De Luca, A., Graziani, E., Anticoli, S., Simeoni, S., Terzano, C., and Mannino, F. Respiratory allergy to Cupressus sempervirens in Rome. Allergol.Immunopathol.(Madr.) 1997;25(5):229-232.
    5. 106005. Samaran Q, Clark E, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Cupressus sempervirens resin and cross-reaction with colophonium. Contact Dermatitis 2020;83(1):33-35.

    Gemcitabine

    Listed in the ADVERSE REACTIONS section of the FDA label for Gemcitabine. Read the label on DailyMed ›

Effects for Gemcitabine come from the ADVERSE REACTIONS section of its FDA label; effects for Cypress come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 53,020 voluntary FDA FAERS reports for Gemcitabine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Gemcitabine

This page covers Cypress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Gemcitabine page lists 39 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).

By severity: 3 major · 35 moderate · 1 minor.

Open the Gemcitabine interaction page

One more smart check

Taking Cypress as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Cypress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cypress. Even though Cypress itself has no known interaction with Gemcitabine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cypress and Gemcitabine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cypress
Steady interest

#757 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Gemcitabine
Steady interest

#2,588 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cypress reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cypress and Gemcitabine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cypress

What is Cypress?

  • Circulation and varicose veins
  • Coughs and respiratory complaints
  • Excess sweating
  • Skin and minor wounds
  • Aromatherapy for relaxation

Cypress comes from the Mediterranean cypress tree and is most often used as an essential oil in aromatherapy or skin care, and traditionally for circulation and respiratory complaints. High-quality human evidence for these uses is very limited, so it should not replace proven treatments. The essential oil is for external use only and should be diluted, and you should talk with your pharmacist or doctor before using it.

Cupressus sempervirens · Cupressaceae · Cones (galbuli), leaves/needles, and essential oil · Essential oil, extracts, capsules, and dried plant material

An interaction check asks whether these two react with each other — it does not ask whether Cypress is a good idea for someone in your situation. Here is what our Cypress record says about it on its own.

Cypress: dosing

There is no standardized or well-established dose for cypress. Products vary widely in strength and form, so the right amount depends on how it is being used.For essential oil used on the skin, it should always be diluted in a carrier oil rather than applied straight. Do not take cypress essential oil by mouth.

From our Cypress monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cypress monograph & all interactions
Medication

About Gemcitabine Injection

What Is Gemcitabine Injection Used For?

Brand name: Gemzar

Gemcitabine Injection (available as Avgemsi, Gemcitabine, and Infugem) is used to treat several types of cancer. It is given in combination with carboplatin for advanced ovarian cancer that has returned at least 6 months after platinum-based treatment, and in combination with paclitaxel as a first-line treatment for metastatic breast cancer after prior chemotherapy with an anthracycline (a specific class of chemo drug).

It is also given in combination with cisplatin for non-small cell lung cancer (NSCLC) that cannot be removed surgically or has spread. For pancreatic cancer that is locally advanced or has spread, it is used as a single agent — including in patients who have already been treated with fluorouracil.

Most-Reported Side Effects for Gemcitabine

From FAERS, the FDA’s public side-effect reporting system (53,020 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 4,850 reports
Thrombocytopenia 3,706 reports
Neutropenia 3,295 reports
Anemia 3,084 reports
Malignant neoplasm progression 2,912 reports
See full Gemcitabine Injection drug information
Keep checking

Other Drugs & Cypress

Browse every other medication we’ve checked against Cypress — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Cypress page.

No interaction 2,707 drugs checked — show the list

We also checked Cypress against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Cypress list.

See the full Cypress interactions page
See every supplement checked against Gemcitabine, ranked by severity
Evidence & sources

Cypress References

The 7 references that drive our Cypress monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Geller-Bernstein, C., Waisel, Y., and Lahoz, C. Environment and sensitization to cypress in Israel. Allerg.Immunol.(Paris) 2000;32(3):92-93.
  3. Papa, G., Romano, A., Quaratino, D., Di Fonso, M., Viola, M., Artesani, M. C., Sernia, S., Di Gioacchino, M., and Venuti, A. Prevalence of sensitization to Cupressus sempervirens: a 4-year retrospective study. Sci.Total Environ. 4-10-2001;270(1-3):83-87. PubMed
  4. Togawa, A., Panzani, R. C., Garza, M. A., Kishikawa, R., Goldblum, R. M., and Midoro-Horiuti, T. Identification of italian cypress (Cupressus sempervirens) pollen allergen Cup s 3 using homology and cross-reactivity. Ann.Allergy Asthma Immunol. 2006;97(3 PubMed
  5. De Luca, A., Graziani, E., Anticoli, S., Simeoni, S., Terzano, C., and Mannino, F. Respiratory allergy to Cupressus sempervirens in Rome. Allergol.Immunopathol.(Madr.) 1997;25(5):229-232.
  6. Ulusal BG, Arikan S, Durusoy C. Anticoagulant effect of Cupressus sempervirens. Phytother Res. 2007 Nov;21(11):1116.
  7. Samaran Q, Clark E, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Cupressus sempervirens resin and cross-reaction with colophonium. Contact Dermatitis 2020;83(1):33-35.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cypress and Gemcitabine Together: Common Questions

Is it safe to take Cypress with Gemcitabine?
We do not list a known interaction between Cypress and Gemcitabine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cypress and Gemcitabine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Cypress and Gemcitabine combination checked?
Interactions in our licensed database are recorded against drug classes. Gemcitabine is filed under 2 classifications, and Cypress has documented interactions with 1 drug class — none of Gemcitabine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cypress interact with any other medications?
Yes. Cypress has 122 documented drug interactions in our database — Gemcitabine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Gemcitabine interact with any supplements?
Yes. Gemcitabine has documented interactions with 39 supplements in our database — Cypress is not one of them. The Gemcitabine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cypress monograph Uses, safety profile, and every drug interaction in one place Gemcitabine Injection drug information The full plain-English guide to this medication Gemcitabine supplement interactions Every supplement checked against Gemcitabine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Gemcitabine and Cypress?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.