Drug & supplement interaction

Divi-divi + Afatinib Dimaleate

Afatinib Dimaleate brand name: Gilotrif.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Divi-divi and Afatinib Dimaleate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Divi-divi and Afatinib Dimaleate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Afatinib Dimaleate and Divi-divi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Divi-divi at all — not against Afatinib Dimaleate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Divi-divi safety at a glance

Divi-divi overall Not established There is little reliable human safety data for medicinal use of divi-divi.
Pregnancy Avoid Safety has not been established, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data exists for nursing, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Afatinib Dimaleate and Divi-divi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Afatinib Dimaleate’s Own FDA Label Lists

This is not an interaction — none of it involves Divi-divi. These are the most notable effects listed in the ADVERSE REACTIONS section of Afatinib Dimaleate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dehydration Worth acting on
  • Low potassium Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • A severe skin reaction Worth acting on
  • Kidney problems Worth acting on
  • Shortness of breath Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Afatinib Dimaleate. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,587 voluntary FDA FAERS reports for Afatinib Dimaleate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Divi-divi’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Divi-divi side to compare — that is a limit of the record, not a statement that Divi-divi has no side effects.

Everything else you take

See Every Supplement That Interacts With Afatinib Dimaleate

This page covers Divi-divi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Afatinib Dimaleate page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Afatinib Dimaleate page

“Afatinib (Gilotrif) is a targeted lung cancer therapy, and because its effectiveness depends on keeping a steady blood level, this list deserves genuine care. Most of the 54 supplements here either change how much of the drug the gut absorbs or interfere with P-glycoprotein, a pump that moves afatinib across cell walls, pushing its lev…”

Reviewed by 2 · Jul 18, 2026

Open the Afatinib Dimaleate interaction page

One more smart check

Taking Divi-divi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing Divi-divi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Divi-divi. Even though Divi-divi itself has no known interaction with Afatinib Dimaleate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Divi-divi and Afatinib Dimaleate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Divi-divi
Steady interest

#948 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Afatinib Dimaleate
Top half

#739 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Divi-divi is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Divi-divi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Divi-divi and Afatinib Dimaleate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Divi-divi

What is Divi-divi?

  • Source of tannins for tanning leather
  • Traditional astringent for skin
  • Mouth and throat irritation (traditional gargles)
  • Wound and sore care (folk use)
  • Mild digestive complaints (folk use)

Divi-divi is a tropical tree whose tannin-rich seed pods have long been used in leather tanning and in traditional folk remedies, mostly as an astringent. There is very little modern human research to support any health benefit, so it should not be relied on to treat any medical condition. If you are considering it, talk with a pharmacist or doctor first.

Caesalpinia coriaria · Fabaceae · Seed pods (and sometimes bark) · Powdered pod extract, decoctions, and traditional topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Divi-divi is a good idea for someone in your situation. Here is what our Divi-divi record says about it on its own.

Divi-divi: dosing

There is no established or standardized medicinal dose for divi-divi. Traditional preparations vary widely and are not measured in a consistent way.If you choose to use a product that contains divi-divi, follow the directions on the label and do not exceed the suggested amount.

From our Divi-divi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Divi-divi monograph & all interactions
Medication

About Afatinib

What Is Afatinib Used For?

Brand name: Gilotrif

Gilotrif (afatinib) is used to treat metastatic non-small cell lung cancer (NSCLC) — cancer that has spread and cannot be removed by surgery. It has two specific approved uses.

First, Gilotrif is used as an initial treatment for metastatic NSCLC when the tumor carries certain EGFR mutations (gene changes in the cancer cells) confirmed by an FDA-approved test — specifically non-resistant mutations. Second, Gilotrif is used to treat metastatic squamous NSCLC (a particular cell type of lung cancer) in patients whose cancer progressed during or after platinum-based chemotherapy.

See full Afatinib drug information
Keep checking

Other Drugs & Divi-divi

Browse every other medication we’ve checked against Divi-divi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Divi-divi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Divi-divi list.

See the full Divi-divi interactions page
See every supplement checked against Afatinib Dimaleate, ranked by severity
Evidence & sources

Divi-divi References

The 1 sources that drive our Divi-divi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Divi-divi is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Tannins — MedlinePlus / NIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Divi-divi and Afatinib Dimaleate Together: Common Questions

Is it safe to take Divi-divi with Afatinib Dimaleate?
We do not list a known interaction between Divi-divi and Afatinib Dimaleate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Afatinib Dimaleate interact with any supplements?
Yes. Afatinib Dimaleate has documented interactions with 54 supplements in our database — Divi-divi is not one of them. The Afatinib Dimaleate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Divi-divi monograph Uses, safety profile, and every drug interaction in one place Afatinib drug information The full plain-English guide to this medication Afatinib Dimaleate supplement interactions Every supplement checked against Afatinib Dimaleate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Afatinib Dimaleate and Divi-divi?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.