Drug & supplement interaction

Dulse + Sparsentan

Sparsentan brand name: Filspari.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Dulse has a minor interaction with Sparsentan. Theoretically, dulse might increase the risk of hyperkalemia when taken with ARBs.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Dulse and Sparsentan

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANGIOTENSIN RECEPTOR BLOCKERS (ARBs)

Why this applies to Sparsentan

Sparsentan falls under ANGIOTENSIN RECEPTOR BLOCKERS (ARBs) — the group Dulse interacts with.

Theoretically, dulse might increase the risk of hyperkalemia when taken with ARBs.
Dulse is rich in potassium. ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels. However, using these drugs while consuming dulse in quantities that provide higher amounts of potassium daily might increase the risk of hyperkalemia. Additionally, in vitro research suggests that dulse protein hydrolysates inhibit the activity of angiotensin converting enzyme (ACE). However, these effects have not been demonstrated in humans.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing dulse with Sparsentan (Filspari). Sparsentan works partly like an ARB, blocking the angiotensin system, and one effect of that is your kidneys hold onto a bit more potassium than usual. Dulse, a red seaweed, is naturally high in potassium. So in theory, loading up on concentrated dulse supplements on top of Sparsentan could nudge your potassium higher, a state called hyperkalemia.

I want to be honest about how soft this evidence is. It's based on pharmacology reasoning, not real-world cases, and normal food amounts of dulse usually won't matter. High-dose supplements are the bigger concern, especially if your kidneys aren't working well. Since high potassium can cause muscle weakness or irregular heartbeats, just check with your pharmacist or doctor before using dulse supplements.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  2. McGrath BM, Harmon JP, Bishop G. Palmaria palmata (Dulse) as an unusual maritime aetiology of hyperkalemia in a patient with chronic renal failure: a case report. J Med Case Rep. 2010;4:301. PubMed
  3. Furuta T, Miyabe Y, Yasui H, Kinoshita Y, Kishimura H. Angiotensin I converting enzyme inhibitory peptides derived from phycobiliproteins of dulse Palmaria palmata. Mar Drugs. 2016;14(2):32. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Dulse Also Interacts With Other Medications

Dulse has 23 moderate, 61 minor known drug interactions in our database — the Sparsentan one above is one of them. If you take anything else, check it against the full list below.

Moderate 23 Minor 61 No known interaction 2,746 (incl. Sparsentan)
Taking anything else?

Check Another of Your Medications Against Dulse

Covers the 2,830 medications we’ve checked against Dulse. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Sparsentan

This page covers Dulse only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sparsentan page lists 172 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 128 moderate · 38 minor.

From our pharmacist’s overview on the Sparsentan page

“Sparsentan (Filspari) treats the kidney disease IgA nephropathy and carries its own liver warning, so handle its supplement list with genuine care; six of the 172 entries rate major. Most do one of two things.”

Reviewed by 2 · Jul 18, 2026

Open the Sparsentan interaction page

One more smart check

Taking Dulse as Part of a Dietary Supplement Product? Check It for Interactions

We hold 546 real supplement products containing Dulse, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dulse. Your product may carry other ingredients that interact with Sparsentan too, on top of Dulse — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dulse and Sparsentan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dulse
Top 25%

#272 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sparsentan
Top 10%

#196 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Dulse

What is Dulse?

Dulse
  • Nutritional supplement (iodine, minerals)
  • Source of plant protein
  • General wellness
  • Anti-inflammatory support
  • Thyroid/iodine support

Dulse is a red seaweed eaten as a food in many coastal cultures and is a natural source of iodine, potassium, protein, and antioxidant compounds. As a food it is generally considered safe for most people, but concentrated supplements can deliver large amounts of iodine and potassium, so use caution. Talk to your pharmacist or doctor before using it medicinally, especially if you have thyroid or kidney problems.

Read the full Dulse monograph & all interactions
Keep checking

Other Drugs & Dulse

Browse every other medication we’ve checked against Dulse — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
23Moderate
61Minor
2,745No known interaction
23 Moderate 61 Minor 2,745 No interaction
Moderate

23 interactions

Minor

61 interactions

Showing 60 of 61 minor interactions — see all 61 on the Dulse page.

No interaction 2,745 drugs checked — show the list

We also checked Dulse against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,745 medications checked with no known interaction — see the full Dulse list.

See the full Dulse interactions page
See every supplement checked against Sparsentan, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Dulse monograph › Uses, safety, and every drug interaction in one place Sparsentan supplement interactions › Every supplement checked against Sparsentan, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Dulse and Sparsentan Together: Common Questions

Can you take Dulse with Sparsentan?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Dulse and Sparsentan interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Sparsentan and Dulse?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.