Ecklonia Cava + Alpelisib
Alpelisib brand name: Piqray.
We found no known interaction between Ecklonia Cava and Alpelisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Alpelisib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Ecklonia Cava and Alpelisib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Alpelisib and Ecklonia Cava in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Ecklonia Cava at all — not against Alpelisib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Ecklonia Cava safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Alpelisib Products Have a Food Rule — Ecklonia Cava Should Not Break It
At least one FDA label for a product containing Alpelisib says to take it with food. If you take Ecklonia Cava on an empty stomach out of habit, keep them separate — and take Alpelisib with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Alpelisib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended Dose: Pediatric patients (2 to less than 18 years of age): 50 mg taken orally once daily with food.
From the Dosage and Administration section of the FDA label we read for Alpelisib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Alpelisib Is Prescribed For, and What Ecklonia Cava Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Alpelisib is a prescription medicine with approved uses on its FDA label. Ecklonia Cava is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Alpelisib is prescribed for: Alpelisib is approved for two distinct uses, each tied to a specific brand. Piqray is used in combination with another drug called fulvestrant to treat adults with hormone receptor (HR)-positive, HER2-negative, advanced or metastatic breast cancer whose tumors carry a PIK3CA mutation — and only after the cancer has progressed on or after a hormone-based treatment. A companion diagnostic test is required before starting Piqray. Vijoice is used to treat adults and children 2 years of age and older who have severe manifestations of PIK3CA-Related Overgrowth Spectrum (PROS) — a rare condition where PIK3CA gene mutations cause abnormal tissue, vascular, and bone overgrowth — and who need systemic (whole-body) therapy.
Read the rest of what Alpelisib is prescribed for
Vijoice's approval for PROS was granted under the FDA's accelerated approval pathway based on response data, and continued approval may depend on confirmatory trials.
Ecklonia Cava has been studied for:
-
Cancer studied, not established Ecklonia Cava has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Ecklonia Cava for cancer
Although there is interest in using oral Ecklonia cava for cancer, there is insufficient reliable information about the clinical effects of Ecklonia cava for this condition.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Alpelisib on your own; if you are taking Ecklonia Cava for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Alpelisib
This page covers Ecklonia Cava only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alpelisib page lists 139 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 96 moderate · 40 minor.
From our pharmacist’s overview on the Alpelisib page
“Alpelisib (Piqray) treats PIK3CA-mutated breast cancer, and a drug doing that job leaves little room for supplements that shift its blood level. Yet that is what most of this list does: 121 of the 139 ingredients on file can raise or lower alpelisib through CYP3A4, the liver enzyme that clears it.”
Reviewed by 2 · Jul 18, 2026
Taking Ecklonia Cava as Part of a Dietary Supplement Product? Check It for Interactions
We hold 63 real supplement products containing Ecklonia Cava, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ecklonia Cava. Even though Ecklonia Cava itself has no known interaction with Alpelisib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Ecklonia Cava and Alpelisib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,093 of 1,452 supplements looked up here in the last 7 days
#1,458 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ecklonia Cava reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ecklonia Cava and Alpelisib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Ecklonia Cava
What is Ecklonia Cava?
- Antioxidant support
- Heart and circulation health
- Blood sugar support
- Inflammation
- Allergy symptoms
- Erectile or sexual function
Ecklonia cava is an edible brown seaweed rich in plant compounds called phlorotannins that are studied as antioxidants. Early human and lab research hints at possible benefits for blood vessels, blood sugar, and inflammation, but the evidence is limited and far from proven. Because it contains iodine and has not been well studied for long-term safety, talk with your pharmacist or doctor before using it.
Ecklonia cava · Lessoniaceae · Whole brown seaweed (thallus), used to make extracts · Capsules, tablets, powders, and standardized extracts (often sold under branded names)
An interaction check asks whether these two react with each other — it does not ask whether Ecklonia Cava is a good idea for someone in your situation. Here is what our Ecklonia Cava record says about it on its own.
Ecklonia Cava: dosing
There is no official or standardized dose of Ecklonia cava. Studies have used different branded extracts at different amounts, so there is no single recommended dose for the general public.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount. A pharmacist can help you review the product and decide whether it is appropriate for you, especially if you take other medicines or have a health condition.
From our Ecklonia Cava monograph — the full record covers uses, side effects and every documented interaction.
About Alpelisib
What Is Alpelisib Used For?
Brand name: Piqray
Alpelisib is approved for two distinct uses, each tied to a specific brand. Piqray is used in combination with another drug called fulvestrant to treat adults with hormone receptor (HR)-positive, HER2-negative, advanced or metastatic breast cancer whose tumors carry a PIK3CA mutation — and only after the cancer has progressed on or after a hormone-based treatment. A companion diagnostic test is required before starting Piqray.
Vijoice is used to treat adults and children 2 years of age and older who have severe manifestations of PIK3CA-Related Overgrowth Spectrum (PROS) — a rare condition where PIK3CA gene mutations cause abnormal tissue, vascular, and bone overgrowth — and who need systemic (whole-body) therapy. Vijoice's approval for PROS was granted under the FDA's accelerated approval pathway based on response data, and continued approval may depend on confirmatory trials.
Other Drugs & Ecklonia Cava
Browse every other medication we’ve checked against Ecklonia Cava — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Ecklonia Cava against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ecklonia Cava list.
Ecklonia Cava References
The 1 references that drive our Ecklonia Cava monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Lee DH, Park MY, Shim BJ, et al. Effects of Ecklonia cava polyphenol in individuals with hypercholesterolemia: a pilot study. J Med Food. 2012;15(11):1038-44.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Ecklonia Cava and Alpelisib Together: Common Questions
Is it safe to take Ecklonia Cava with Alpelisib?
Do Ecklonia Cava and Alpelisib have any of the same side effects?
Should I take Ecklonia Cava and Alpelisib at the same time of day?
Are Ecklonia Cava and Alpelisib used for the same thing?
Does Alpelisib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.