Drug & supplement interaction

English Adder's Tongue + Isosorbide Dinitrate

Isosorbide Dinitrate brand names: Isordil, Angitak, Cedocard Retard, Isoket Retard, Isoket.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between English Adder's Tongue and Isosorbide Dinitrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

English Adder's Tongue and Isosorbide Dinitrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isosorbide Dinitrate and English Adder's Tongue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for English Adder's Tongue at all — not against Isosorbide Dinitrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

English Adder's Tongue safety at a glance

English Adder's To... overall Not established Very little modern safety data exists, so caution is warranted, especially when taken by mouth.
Pregnancy Avoid There is no reliable safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isosorbide Dinitrate and English Adder's Tongue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Isosorbide Dinitrate’s Own FDA Label Lists

This is not an interaction — none of it involves English Adder's Tongue. These are the most notable effects listed in the ADVERSE REACTIONS section of Isosorbide Dinitrate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on mentioned in 6.2% of FDA reports for Isosorbide Dinitrate
  • Kidney stones Worth acting on
  • Muscle weakness Worth acting on
  • Bleeding in the gut Worth acting on
  • Low potassium Worth acting on
  • A slow heartbeat Worth acting on
  • Chest pain Worth acting on mentioned in 5.9% of FDA reports for Isosorbide Dinitrate
  • Heart failure Worth acting on
  • Shortness of breath Worth acting on mentioned in 8.6% of FDA reports for Isosorbide Dinitrate
  • Fainting Worth acting on

Showing the 10 most notable of 56 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed › Where a percentage is shown, it is the share of 19,814 voluntary FDA FAERS reports for Isosorbide Dinitrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. English Adder's Tongue’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no English Adder's Tongue side to compare — that is a limit of the record, not a statement that English Adder's Tongue has no side effects.

From our Q&A

Questions About English Adder's Tongue or Isosorbide Dinitrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers English Adder's Tongue or Isosorbide Dinitrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isosorbide Dinitrate

This page covers English Adder's Tongue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isosorbide Dinitrate page lists 22 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Coleus (major), Hawthorn (major) and Beer (moderate).

By severity: 4 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Isosorbide Dinitrate page

“Isosorbide dinitrate (Isordil, Isoket) relaxes blood vessels to prevent and relieve angina, so a supplement that pushes that relaxation further, or works against it, is not a small thing, and this list of 22 warrants genuine care. Four entries rate major: herbs with vasodilating effects of their own, like hawthorn, that can stack on to…”

Reviewed by 2 · Jul 18, 2026

Open the Isosorbide Dinitrate interaction page

How much people look this up

Where English Adder's Tongue and Isosorbide Dinitrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement English Adder's Tongue
Steady interest

#1,384 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isosorbide Dinitrate
Steady interest

#1,710 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. English Adder's Tongue is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every English Adder's Tongue reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The English Adder's Tongue and Isosorbide Dinitrate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About English Adder's Tongue

What is English Adder's Tongue?

  • Minor wounds and skin irritation
  • Bruises and swelling
  • Insect bites
  • Soothing inflamed skin
  • Traditional eye washes (historical)

English Adder's Tongue is a small fern long used in folk medicine as a topical remedy for wounds, bruises, and skin irritation. There is very little modern scientific research to show whether it works or how safe it is, so use it cautiously and treat any health claims with skepticism.

Ophioglossum vulgatum · Ophioglossaceae · Leaves (fronds), sometimes the whole plant · Fresh leaves, salve or ointment, poultice, infused oil, tea

An interaction check asks whether these two react with each other — it does not ask whether English Adder's Tongue is a good idea for someone in your situation. Here is what our English Adder's Tongue record says about it on its own.

English Adder's Tongue: dosing

There is no established standardized dose for English Adder's Tongue. Traditional use focused on topical salves and poultices made from the fresh leaves, with no precise measured amounts.If you find a commercial product, follow the directions on the label and do not exceed them.

From our English Adder's Tongue monograph — the full record covers uses, side effects and every documented interaction.

Read the full English Adder's Tongue monograph & all interactions
Medication

About Isosorbide

What Is Isosorbide Used For?

Brand names: Isordil, Angitak, Cedocard Retard, Isoket Retard, Isoket

Isosorbide is used to prevent angina pectoris — chest pain or tightness caused by coronary artery disease. Both isosorbide dinitrate tablets and isosorbide mononitrate tablets (including Monoket and Isordil) are used for this purpose.

Important: none of these oral formulations work fast enough to stop a chest pain episode that has already started. They are taken on a schedule to prevent angina, not to treat it in the moment.

Most-Reported Side Effects for Isosorbide Dinitrate

From FAERS, the FDA’s public side-effect reporting system (19,814 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,696 reports
Nausea 1,406 reports
Fatigue 1,382 reports
Dizziness 1,336 reports
Diarrhea 1,334 reports
See full Isosorbide drug information
Keep checking

Other Drugs & English Adder's Tongue

Browse every other medication we’ve checked against English Adder's Tongue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked English Adder's Tongue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full English Adder's Tongue list.

See the full English Adder's Tongue interactions page
See every supplement checked against Isosorbide Dinitrate, ranked by severity
Evidence & sources

English Adder's Tongue References

The 2 sources that drive our English Adder's Tongue monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. English Adder's Tongue is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking English Adder's Tongue and Isosorbide Dinitrate Together: Common Questions

Is it safe to take English Adder's Tongue with Isosorbide Dinitrate?
We do not list a known interaction between English Adder's Tongue and Isosorbide Dinitrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Isosorbide Dinitrate interact with any supplements?
Yes. Isosorbide Dinitrate has documented interactions with 22 supplements in our database — English Adder's Tongue is not one of them. The Isosorbide Dinitrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

English Adder's Tongue monograph Uses, safety profile, and every drug interaction in one place Isosorbide drug information The full plain-English guide to this medication Isosorbide Dinitrate supplement interactions Every supplement checked against Isosorbide Dinitrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isosorbide Dinitrate and English Adder's Tongue?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.