Drug & supplement interaction

Epiandrosterone + Duloxetine

Duloxetine brand names: Cymbalta, Drizalma Sprinkle, Irenka.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Epiandrosterone and Duloxetine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Epiandrosterone and Duloxetine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Duloxetine and Epiandrosterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Epiandrosterone at all — not against Duloxetine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Epiandrosterone safety at a glance

Epiandrosterone overall Use caution It is a hormone-related supplement with limited safety data and real potential for androgenic side effects.
Pregnancy Possibly Unsafe When used orally. Anabolic androgenic steroids, such as epiandrosterone, can disrupt the body's hormonal balance and cause various adverse effects including red... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Anabolic androgenic steroids, such as epiandrosterone, can disrupt the body's hormonal balance and cause various adverse effects including red... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Duloxetine and Epiandrosterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Duloxetine’s Own FDA Label Lists

This is not an interaction — none of it involves Epiandrosterone. These are the most notable effects listed in the ADVERSE REACTIONS section of Duloxetine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Serotonin syndrome Worth acting on
  • Thoughts of self-harm Worth acting on
  • Trouble passing urine Worth acting on
  • Low sodium Worth acting on
  • Fainting Worth acting on
  • Seizures Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • Erection problems

Showing the 10 most notable of 29 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Duloxetine. Read the label on DailyMed › Epiandrosterone’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Epiandrosterone side to compare — that is a limit of the record, not a statement that Epiandrosterone has no side effects.

Special populations

Epiandrosterone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Anabolic androgenic steroids, such as epiandrosterone, can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The US Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Epiandrosterone or Duloxetine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Epiandrosterone or Duloxetine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Duloxetine

This page covers Epiandrosterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duloxetine page lists 132 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Lithium (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 107 moderate · 20 minor.

Open the Duloxetine interaction page

One more smart check

Taking Epiandrosterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 37 real supplement products containing Epiandrosterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Epiandrosterone. Even though Epiandrosterone itself has no known interaction with Duloxetine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Epiandrosterone and Duloxetine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Epiandrosterone
Top half

#707 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Duloxetine
Top 5%

#47 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Epiandrosterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Epiandrosterone and Duloxetine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Epiandrosterone

What is Epiandrosterone?

  • Muscle building and strength
  • Bodybuilding 'prohormone' supplement
  • Boosting androgen/DHT levels
  • Athletic performance
  • Fat loss and body recomposition

Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic performance. There is very little high-quality human research showing it works, it can carry hormone-related side effects, and it may cause a positive result on drug tests, so caution is strongly advised.

Synthesized compound (not a plant part) · Capsules, tablets, powders

An interaction check asks whether these two react with each other — it does not ask whether Epiandrosterone is a good idea for someone in your situation. Here is what our Epiandrosterone record says about it on its own.

Epiandrosterone: dosing

There is no established, medically recommended dose for epiandrosterone. It has not been studied well enough to define a safe and effective amount.If a product is used, follow the directions on the label and do not exceed them.

From our Epiandrosterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Epiandrosterone monograph & all interactions
Medication

About Duloxetine

What Is Duloxetine Used For?

Brand names: Cymbalta, Drizalma Sprinkle, Irenka

Duloxetine delayed-release capsules treat major depressive disorder (MDD) and generalized anxiety disorder (GAD) in adults. They also manage diabetic peripheral neuropathic pain (nerve pain from diabetes), fibromyalgia, and chronic musculoskeletal pain (such as chronic low back pain and pain from osteoarthritis) in adults.

GAD is also approved in pediatric patients 7 years and older for Cymbalta, Drizalma Sprinkle, and certain duloxetine delayed-release capsule products. Fibromyalgia is approved in patients 13 years and older for Cymbalta and some duloxetine delayed-release capsule products. Age-specific approvals vary by product — follow your prescriber's guidance on which product is right for your age group.

See full Duloxetine drug information
Keep checking

Other Drugs & Epiandrosterone

Browse every other medication we’ve checked against Epiandrosterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Epiandrosterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Epiandrosterone list.

See the full Epiandrosterone interactions page
See every supplement checked against Duloxetine, ranked by severity
Evidence & sources

Epiandrosterone References

The 1 references that drive our Epiandrosterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Epiandrosterone and Duloxetine Together: Common Questions

Is it safe to take Epiandrosterone with Duloxetine?
We do not list a known interaction between Epiandrosterone and Duloxetine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Duloxetine interact with any supplements?
Yes. Duloxetine has documented interactions with 132 supplements in our database — Epiandrosterone is not one of them. The Duloxetine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Epiandrosterone monograph Uses, safety profile, and every drug interaction in one place Duloxetine drug information The full plain-English guide to this medication Duloxetine supplement interactions Every supplement checked against Duloxetine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Duloxetine and Epiandrosterone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.