Drug & supplement interaction

European Chestnut + Eluxadoline

Eluxadoline brand name: Viberzi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between European Chestnut and Eluxadoline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Eluxadoline states a food rule worth keeping to.

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Interaction report

European Chestnut and Eluxadoline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Eluxadoline and European Chestnut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for European Chestnut at all — not against Eluxadoline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

European Chestnut safety at a glance

European Chestnut overall Use caution The nut is a common food, but concentrated leaf or bark extracts have not been well studied for safety.
Pregnancy Avoid There is not enough safety information, so medicinal use during pregnancy is best avoided.
Breastfeeding Avoid Safety during breastfeeding is unknown, so medicinal use is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Eluxadoline and European Chestnut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Eluxadoline’s Own FDA Label Lists

This is not an interaction — none of it involves European Chestnut. These are the most notable effects listed in the ADVERSE REACTIONS section of Eluxadoline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Pancreatitis Worth acting on mentioned in 9.5% of FDA reports for Eluxadoline
  • Wheezing Worth acting on
  • Chest pain Worth acting on
  • Shortness of breath Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Stomach pain mentioned in 19.2% of FDA reports for Eluxadoline
  • Heartburn

Showing the 10 most notable of 18 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Eluxadoline. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,928 voluntary FDA FAERS reports for Eluxadoline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. European Chestnut’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no European Chestnut side to compare — that is a limit of the record, not a statement that European Chestnut has no side effects.

How to take them

Some Eluxadoline Products Have a Food Rule — European Chestnut Should Not Break It

At least one FDA label for a product containing Eluxadoline says to take it with food. If you take European Chestnut on an empty stomach out of habit, keep them separate — and take Eluxadoline with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Eluxadoline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended dosage of VIBERZI is 100 mg taken orally twice daily with food.

From the Dosage and Administration section of the FDA label we read for Eluxadoline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Eluxadoline Is Prescribed For, and What European Chestnut Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Eluxadoline is a prescription medicine with approved uses on its FDA label. European Chestnut is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Eluxadoline is prescribed for: Viberzi (eluxadoline) is approved for adults with irritable bowel syndrome with diarrhea (IBS-D) — a condition that causes chronic abdominal pain, cramping, and frequent loose stools. It is taken orally twice daily and is intended for ongoing management of IBS-D symptoms, not as a one-time or as-needed treatment.

European Chestnut has been studied for:

  • Diarrhea studied, not established European Chestnut has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    European Chestnut for diarrhea

    Although there is interest in using oral European chestnut for diarrhea, there is insufficient reliable information about the clinical effects of European chestnut for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Eluxadoline on your own; if you are taking European Chestnut for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About European Chestnut or Eluxadoline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers European Chestnut or Eluxadoline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Eluxadoline

This page covers European Chestnut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Eluxadoline page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), African Wild Potato (moderate), Banderol (moderate), Beer (moderate) and Caffeic Acid (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Eluxadoline page

“One supplement here can keep a dose of eluxadoline (Viberzi) from being fully absorbed. Activated charcoal soaks up oral medicines in the gut, and of the 23 supplements and herbs with an interaction on file, it is the only one rated major, reason enough to give this page a careful read.”

Reviewed by 2 · Jul 18, 2026

Open the Eluxadoline interaction page

How much people look this up

Where European Chestnut and Eluxadoline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement European Chestnut
Steady interest

#1,178 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Eluxadoline
Steady interest

#2,579 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every European Chestnut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The European Chestnut and Eluxadoline records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About European Chestnut

What is European Chestnut?

  • Coughs and respiratory irritation
  • Diarrhea and digestive upset
  • Sore throat
  • Wound and skin care
  • General antioxidant support

European Chestnut is a tree whose leaves and nuts have a long history of use for coughs, diarrhea, and skin care, mostly in traditional folk medicine. High-quality human studies are lacking, so its benefits remain unproven, and it should be used cautiously and discussed with a pharmacist or doctor.

Castanea sativa · Fagaceae · Leaves, nuts (seeds), bark, and flowers · Tea, liquid extract, capsules, honey, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether European Chestnut is a good idea for someone in your situation. Here is what our European Chestnut record says about it on its own.

European Chestnut: dosing

There is no standardized or well-established medicinal dose for European Chestnut. Products vary widely in strength and in which part of the plant they use.If you choose to use a chestnut product, follow the directions on the label and do not exceed the recommended amount.

From our European Chestnut monograph — the full record covers uses, side effects and every documented interaction.

Read the full European Chestnut monograph & all interactions
Medication

About Eluxadoline

What Is Eluxadoline Used For?

Brand name: Viberzi

Viberzi (eluxadoline) is approved for adults with irritable bowel syndrome with diarrhea (IBS-D) — a condition that causes chronic abdominal pain, cramping, and frequent loose stools.

It is taken orally twice daily and is intended for ongoing management of IBS-D symptoms, not as a one-time or as-needed treatment.

Most-Reported Side Effects for Eluxadoline

From FAERS, the FDA’s public side-effect reporting system (2,928 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Abdominal pain 352 reports
Diarrhea 345 reports
Constipation 283 reports
Pancreatitis 278 reports
Nausea 219 reports
See full Eluxadoline drug information
Keep checking

Other Drugs & European Chestnut

Browse every other medication we’ve checked against European Chestnut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked European Chestnut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full European Chestnut list.

See the full European Chestnut interactions page
See every supplement checked against Eluxadoline, ranked by severity
Evidence & sources

European Chestnut References

The 1 references that drive our European Chestnut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking European Chestnut and Eluxadoline Together: Common Questions

Is it safe to take European Chestnut with Eluxadoline?
We do not list a known interaction between European Chestnut and Eluxadoline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take European Chestnut and Eluxadoline at the same time of day?
At least one FDA label for a product containing Eluxadoline says to take it with food. If you take European Chestnut on an empty stomach out of habit, keep them separate and take Eluxadoline with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Eluxadoline products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are European Chestnut and Eluxadoline used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for European Chestnut in each. That is a conversation for your prescriber, especially if Eluxadoline is being adjusted to a target.
Does Eluxadoline interact with any supplements?
Yes. Eluxadoline has documented interactions with 23 supplements in our database — European Chestnut is not one of them. The Eluxadoline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

European Chestnut monograph Uses, safety profile, and every drug interaction in one place Eluxadoline drug information The full plain-English guide to this medication Eluxadoline supplement interactions Every supplement checked against Eluxadoline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Eluxadoline and European Chestnut?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.