Drug & supplement interaction

Fadogia Agrestis + Primaquine Phosphate

Primaquine Phosphate brand name: Primaquine.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fadogia Agrestis and Primaquine Phosphate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fadogia Agrestis and Primaquine Phosphate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Primaquine Phosphate and Fadogia Agrestis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fadogia Agrestis at all — not against Primaquine Phosphate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fadogia Agrestis safety at a glance

Fadogia Agrestis overall Use caution Human safety data are lacking and animal studies suggest possible toxicity to the testicles, liver, and kidneys.
Pregnancy Avoid No safety data exist, so it should be avoided during pregnancy.
Breastfeeding Avoid No safety data exist, so it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Primaquine Phosphate and Fadogia Agrestis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Primaquine Phosphate’s Own FDA Label Lists

This is not an interaction — none of it involves Fadogia Agrestis. These are the most notable effects listed in the ADVERSE REACTIONS section of Primaquine Phosphate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Anemia Worth acting on
  • A low white blood cell count Worth acting on
  • Stomach pain
  • Vomiting
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Primaquine Phosphate. Read the label on DailyMed › Where a percentage is shown, it is the share of 81 voluntary FDA FAERS reports for Primaquine Phosphate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Fadogia Agrestis’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Fadogia Agrestis side to compare — that is a limit of the record, not a statement that Fadogia Agrestis has no side effects.

Overlapping uses

What Primaquine Phosphate Is Prescribed For, and What Fadogia Agrestis Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Primaquine Phosphate is a prescription medicine with approved uses on its FDA label. Fadogia Agrestis is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Primaquine Phosphate is prescribed for: Primaquine Phosphate Tablets are indicated for the radical cure of vivax malaria — specifically, to prevent relapse by eliminating the dormant liver forms (hypnozoites) of Plasmodium vivax that survive after the initial infection is treated. It is also used after a course of chloroquine phosphate in people who have had vivax malaria or who are completing malaria-suppression therapy in an area where vivax malaria is common.

Fadogia Agrestis has been studied for:

  • Malaria studied, not established Fadogia Agrestis has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Fadogia Agrestis for malaria

    Although there has been interest in using oral Fadogia agrestis for malaria, there is insufficient reliable information about the clinical effects of Fadogia agrestis for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Primaquine Phosphate on your own; if you are taking Fadogia Agrestis for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Primaquine Phosphate

This page covers Fadogia Agrestis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Primaquine Phosphate page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Grapefruit (moderate).

By severity: 1 major · 8 moderate · 9 minor.

From our pharmacist’s overview on the Primaquine Phosphate page

“Activated charcoal, the only major-rated interaction among the 18 on file, can bind primaquine phosphate (Primaquine) in the gut and shrink how much of each dose your body actually absorbs. That matters more than usual, because this antimalarial exists to wipe out the malaria parasites hiding in the liver, and an under-absorbed course…”

Reviewed by 2 · Jul 18, 2026

Open the Primaquine Phosphate interaction page

One more smart check

Taking Fadogia Agrestis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 59 real supplement products containing Fadogia Agrestis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fadogia Agrestis. Even though Fadogia Agrestis itself has no known interaction with Primaquine Phosphate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fadogia Agrestis and Primaquine Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fadogia Agrestis
Steady interest

#1,106 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Primaquine Phosphate
Top half

#1,077 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Fadogia Agrestis is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fadogia Agrestis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fadogia Agrestis and Primaquine Phosphate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fadogia Agrestis

What is Fadogia Agrestis?

  • Boosting testosterone
  • Improving libido and sexual function
  • Athletic performance and muscle building
  • Traditional African remedy for various ailments

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal data raise real concerns about organ toxicity, so the safety of long-term use in people is unknown. Talk with your pharmacist or doctor before trying it, and avoid it if you are pregnant, breastfeeding, or have any underlying health conditions.

Fadogia agrestis · Rubiaceae · Stem (and sometimes leaves and roots) · Capsules, powders, and tinctures (often sold as a standardized extract)

An interaction check asks whether these two react with each other — it does not ask whether Fadogia Agrestis is a good idea for someone in your situation. Here is what our Fadogia Agrestis record says about it on its own.

Fadogia Agrestis: dosing

There is no established or proven safe dose of Fadogia agrestis for humans. The doses used in supplements are based on animal studies and manufacturer choices, not on human research.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Fadogia Agrestis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fadogia Agrestis monograph & all interactions
Medication

About Primaquine

What Is Primaquine Used For?

Brand name: Primaquine

Primaquine Phosphate Tablets are indicated for the radical cure of vivax malaria — specifically, to prevent relapse by eliminating the dormant liver forms (hypnozoites) of Plasmodium vivax that survive after the initial infection is treated.

It is also used after a course of chloroquine phosphate in people who have had vivax malaria or who are completing malaria-suppression therapy in an area where vivax malaria is common.

See full Primaquine drug information
Keep checking

Other Drugs & Fadogia Agrestis

Browse every other medication we’ve checked against Fadogia Agrestis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fadogia Agrestis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fadogia Agrestis list.

See the full Fadogia Agrestis interactions page
See every supplement checked against Primaquine Phosphate, ranked by severity
Evidence & sources

Fadogia Agrestis References

The 2 sources that drive our Fadogia Agrestis monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Fadogia Agrestis is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fadogia Agrestis and Primaquine Phosphate Together: Common Questions

Is it safe to take Fadogia Agrestis with Primaquine Phosphate?
We do not list a known interaction between Fadogia Agrestis and Primaquine Phosphate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Fadogia Agrestis and Primaquine Phosphate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Fadogia Agrestis in each. That is a conversation for your prescriber, especially if Primaquine Phosphate is being adjusted to a target.
Does Primaquine Phosphate interact with any supplements?
Yes. Primaquine Phosphate has documented interactions with 18 supplements in our database — Fadogia Agrestis is not one of them. The Primaquine Phosphate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fadogia Agrestis monograph Uses, safety profile, and every drug interaction in one place Primaquine drug information The full plain-English guide to this medication Primaquine Phosphate supplement interactions Every supplement checked against Primaquine Phosphate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Primaquine Phosphate and Fadogia Agrestis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.