Drug & supplement interaction

Feverfew + Tretinoin, Benzoyl Peroxide

Tretinoin, Benzoyl Peroxide brand name: Twyneo.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Feverfew has a moderate interaction with Tretinoin, Benzoyl Peroxide. Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Feverfew and Tretinoin, Benzoyl Peroxide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 2C8 (CYP2C8) SUBSTRATES

Why this applies to Tretinoin, Benzoyl Peroxide

Tretinoin, Benzoyl Peroxide falls under CYTOCHROME P450 2C8 (CYP2C8) SUBSTRATES — the group Feverfew interacts with.

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the good news on Twyneo (topical tretinoin with benzoyl peroxide) and feverfew: this is a cream you smooth onto your skin, not a pill you swallow. Even though tretinoin can be processed by the CYP2C8 enzyme that feverfew might block in a lab dish, very little of a topical product gets into your bloodstream. So this theoretical concern really doesn't translate into much for skin treatment.

On top of that, this interaction has only been seen in laboratory studies, never reported in actual people. I wouldn't lose sleep over it. The redness, peeling, or dryness you might notice from Twyneo comes from the cream itself, not from feverfew. If you'd like extra peace of mind, just run it by your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Feverfew Also Interacts With Other Medications

Feverfew has 928 moderate known drug interactions in our database — the Tretinoin, Benzoyl Peroxide one above is one of them. If you take anything else, check it against the full list below.

Moderate 928 No known interaction 1,902 (incl. Tretinoin, Benzoyl Peroxide)
Taking anything else?

Check Another of Your Medications Against Feverfew

Covers the 2,830 medications we’ve checked against Feverfew. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Tretinoin, Benzoyl Peroxide

This page covers Feverfew only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tretinoin, Benzoyl Peroxide page lists 35 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Vitamin A (major), African Wild Potato (moderate), Alfalfa (moderate), Angelica Archangelica (moderate) and Arrach (moderate).

By severity: 1 major · 30 moderate · 4 minor.

From our pharmacist’s overview on the Tretinoin, Benzoyl Peroxide page

“Twyneo pairs tretinoin, a vitamin A derivative, with benzoyl peroxide in an acne cream, and its interaction list deserves genuine care. The single major-rated entry among the 35 supplements on file is vitamin A itself; stacking supplements on a drug built from vitamin A can push levels toward toxicity, so that pairing is the one to und…”

Reviewed by 2 · Jul 18, 2026

Open the Tretinoin, Benzoyl Peroxide interaction page

One more smart check

Taking Feverfew as Part of a Dietary Supplement Product? Check It for Interactions

We hold 520 real supplement products containing Feverfew, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Feverfew. Your product may carry other ingredients that interact with Tretinoin, Benzoyl Peroxide too, on top of Feverfew — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Feverfew and Tretinoin, Benzoyl Peroxide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Feverfew
Top 25%

#274 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tretinoin, Benzoyl Peroxide
Top 25%

#377 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Feverfew

What is Feverfew?

Feverfew
  • Migraine prevention
  • Headache
  • Fever (traditional)
  • Arthritis and joint pain
  • Menstrual discomfort

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally well tolerated for short-term use in most adults but should be avoided during pregnancy and breastfeeding and by people allergic to ragweed and related plants. Talk to your pharmacist or doctor before starting it.

Read the full Feverfew monograph & all interactions
Keep checking

Other Drugs & Feverfew

Browse every other medication we’ve checked against Feverfew — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
928Moderate
0Minor
1,901No known interaction
928 Moderate 1,901 No interaction
Moderate

928 interactions

Showing 60 of 928 moderate interactions — see all 928 on the Feverfew page.

No interaction 1,901 drugs checked — show the list

We also checked Feverfew against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,901 medications checked with no known interaction — see the full Feverfew list.

See the full Feverfew interactions page
See every supplement checked against Tretinoin, Benzoyl Peroxide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Feverfew monograph › Uses, safety, and every drug interaction in one place Tretinoin, Benzoyl Peroxide supplement interactions › Every supplement checked against Tretinoin, Benzoyl Peroxide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Feverfew and Tretinoin, Benzoyl Peroxide Together: Common Questions

Can you take Feverfew with Tretinoin, Benzoyl Peroxide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Feverfew and Tretinoin, Benzoyl Peroxide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tretinoin, Benzoyl Peroxide and Feverfew?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.