Medication interaction hub

What Supplements Interact with Tretinoin, Benzoyl Peroxide?

Tretinoin, Benzoyl Peroxide brand name: Twyneo. Every interaction below applies to the brands too.

35 Interactions 1 Major 30 Moderate 4 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tretinoin, Benzoyl Peroxide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tretinoin, Benzoyl Peroxide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Twyneo pairs tretinoin, a vitamin A derivative, with benzoyl peroxide in an acne cream, and its interaction list deserves genuine care. The single major-rated entry among the 35 supplements on file is vitamin A itself; stacking supplements on a drug built from vitamin A can push levels toward toxicity, so that pairing is the one to understand first. Most of the rest, 20 ingredients from chlorophyll to bergamot oil, add sun sensitivity to a treatment that already makes skin burn more easily.

Thirty entries rate moderate and four minor, and much of it is theoretical, but the patterns matter. A few topical products, DMSO among them, can pull more of the medication through the skin than intended, and eleven ingredients, CBD included, could raise its level by blocking the enzyme that breaks it down, though that comes mostly from lab studies. Ask your pharmacist before keeping vitamin A in the mix, and be stricter than usual about sunscreen.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 30 Minor 4 No known interaction 1,417

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Tretinoin, Benzoyl Peroxide: Top Interactions at a Glance

The most significant Tretinoin, Benzoyl Peroxide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 35 interacting ingredients — plus 1,417 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Tretinoin, Benzoyl Peroxide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Vitamin A + Tretinoin, Benzoyl Peroxidei

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.

Read the full interaction
The complete list

Every Supplement Checked Against Tretinoin, Benzoyl Peroxide

All 1,452 ingredients in our database, ranked by severity — 35 with a Tretinoin, Benzoyl Peroxide interaction on file and 1,417 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tretinoin, Benzoyl Peroxide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin A with Tretinoin, Benzoyl Peroxide?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.

Full Vitamin A + Tretinoin, Benzoyl Peroxide answer

Can you take Cilantro with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.

Full Cilantro + Tretinoin, Benzoyl Peroxide answer

Can you take Coriander with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.

Full Coriander + Tretinoin, Benzoyl Peroxide answer

Can you take Dimethylsulfoxide (dmso) with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Tretinoin, Benzoyl Peroxide answer

Can you take English Ivy with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.

Full English Ivy + Tretinoin, Benzoyl Peroxide answer

Can you take Feverfew with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.

Full Feverfew + Tretinoin, Benzoyl Peroxide answer

Can you take Fig with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.

Full Fig + Tretinoin, Benzoyl Peroxide answer

Can you take Fo-ti with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2C8.

Full Fo-ti + Tretinoin, Benzoyl Peroxide answer

Can you take Khella with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Tretinoin, Benzoyl Peroxide answer

Can you take Licorice with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.

Full Licorice + Tretinoin, Benzoyl Peroxide answer

Can you take Light Therapy with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Tretinoin, Benzoyl Peroxide answer

Can you take Lime with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Tretinoin, Benzoyl Peroxide answer

Can you take Neem with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C8 substrates.

Full Neem + Tretinoin, Benzoyl Peroxide answer

Can you take Quercetin with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2C8 substrates.

Full Quercetin + Tretinoin, Benzoyl Peroxide answer

Can you take Rue with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Tretinoin, Benzoyl Peroxide answer

Can you take St. John's Wort with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Tretinoin, Benzoyl Peroxide answer

Can you take Turpentine Oil with Tretinoin, Benzoyl Peroxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Tretinoin, Benzoyl Peroxide answer

Can you take Alchemilla with Tretinoin, Benzoyl Peroxide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Tretinoin, Benzoyl Peroxide answer

Can you take Celery with Tretinoin, Benzoyl Peroxide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.

Full Celery + Tretinoin, Benzoyl Peroxide answer

Can you take Fucus Vesiculosus with Tretinoin, Benzoyl Peroxide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Tretinoin, Benzoyl Peroxide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tretinoin, Benzoyl Peroxide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tretinoin, Benzoyl Peroxide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tretinoin, Benzoyl Peroxide sits in 4 interaction categories. Open any one to see what the group means:

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Tretinoin, Benzoyl Peroxide through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Tretinoin, Benzoyl Peroxide through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Tretinoin, Benzoyl Peroxide through this category.

Retinoids 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Tretinoin, Benzoyl Peroxide through this category.

Related: does Tretinoin, Benzoyl Peroxide deplete any nutrients?

Tretinoin, Benzoyl Peroxide has 1 reported nutrient association in the research literature — see the Tretinoin, Benzoyl Peroxide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tretinoin, Benzoyl Peroxide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tretinoin, Benzoyl Peroxide.

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Pharmacist Counseling Corner

Tretinoin, Benzoyl Peroxide & Supplements: Common Questions

What supplements interact with Tretinoin, Benzoyl Peroxide?
Our database currently documents 35 ingredients with a known Tretinoin, Benzoyl Peroxide interaction (1 major, 30 moderate, 4 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 35. The highest-ranked right now: Vitamin A, Bergamot, Chenopodium Oil.
Which Tretinoin, Benzoyl Peroxide supplement interactions are the most serious?
The 1 major-rated combination — led by Vitamin A — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Tretinoin, Benzoyl Peroxide?
Plenty of supplements coexist fine with Tretinoin, Benzoyl Peroxide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Twyneo have the same supplement interactions as Tretinoin, Benzoyl Peroxide?
Yes — Twyneo all contain Tretinoin, Benzoyl Peroxide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Tretinoin, Benzoyl Peroxide deplete any vitamins or nutrients?
It might — Tretinoin, Benzoyl Peroxide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Tretinoin, Benzoyl Peroxide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Tretinoin, Benzoyl Peroxide and my other medications?
This page covers Tretinoin, Benzoyl Peroxide against supplements and herbal ingredients. Checking Tretinoin, Benzoyl Peroxide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.