Drug & supplement interaction

Fumitory + Fruquintinib

Fruquintinib brand name: Fruzaqla.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Fumitory and Fruquintinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fumitory and Fruquintinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fruquintinib and Fumitory in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fumitory at all — not against Fruquintinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fumitory safety at a glance

Fumitory overall Use caution Generally used short-term in small amounts, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Lack of safety data means it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fruquintinib and Fumitory? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Fruquintinib’s Own FDA Label Lists

This is not an interaction — none of it involves Fumitory. These are the most notable effects listed in the ADVERSE REACTIONS section of Fruquintinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • A change in thyroid levels Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Mouth irritation or sores
  • Joint pain
  • Muscle pain
  • Stomach pain

Showing the 10 most notable of 13 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Fruquintinib. Read the label on DailyMed › Fumitory’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Fumitory side to compare — that is a limit of the record, not a statement that Fumitory has no side effects.

Everything else you take

See Every Supplement That Interacts With Fruquintinib

This page covers Fumitory only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fruquintinib page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 124 moderate · 38 minor.

From our pharmacist’s overview on the Fruquintinib page

“Fruquintinib (Fruzaqla) is an oral targeted therapy for advanced colorectal cancer, which means keeping its blood level steady is part of what makes it work, and I would treat this supplement list with genuine care. Of the 168 ingredients on file, the large majority interact through CYP3A4, the liver enzyme that clears the drug, so the…”

Reviewed by 2 · Jul 18, 2026

Open the Fruquintinib interaction page

One more smart check

Taking Fumitory as Part of a Dietary Supplement Product? Check It for Interactions

We hold 46 real supplement products containing Fumitory, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fumitory. Even though Fumitory itself has no known interaction with Fruquintinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fumitory and Fruquintinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fumitory
Steady interest

#1,133 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fruquintinib
Top 25%

#546 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Fumitory is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fumitory reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fumitory and Fruquintinib records this page draws on were last updated July 3, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fumitory

What is Fumitory?

  • Digestive and bile-flow complaints
  • Mild liver and gallbladder support
  • Skin conditions like eczema
  • Mild constipation
  • Cleansing or 'detox' tonics

Fumitory is a traditional European herb used mainly for digestive and minor liver or gallbladder complaints, but solid human evidence is very limited. It may cause side effects at higher doses, and its safety is not well established, so talk with your pharmacist or doctor before using it and avoid it during pregnancy and breastfeeding.

Fumaria officinalis · Papaveraceae · Aerial parts (flowering tops, leaves, and stems) · Tea, dried herb, liquid extract, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Fumitory is a good idea for someone in your situation. Here is what our Fumitory record says about it on its own.

Fumitory: dosing

There is no well-established standardized dose for Fumitory. Traditional use involves teas or liquid extracts made from the dried herb, but exact amounts vary widely between products.Because a reliable, evidence-based dose has not been set, the safest approach is to follow the directions on the product label and not exceed them.

From our Fumitory monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fumitory monograph & all interactions
Medication

About Fruquintinib

What Is Fruquintinib Used For?

Brand name: Fruzaqla

Fruzaqla (fruquintinib) is used to treat adults with metastatic colorectal cancer (mCRC) — colorectal cancer that has spread to other parts of the body. It is intended for patients who have already been treated with several prior chemotherapy regimens and other targeted therapies.

Specifically, Fruzaqla is for patients previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and — if their tumor is RAS wild-type and it is medically appropriate — an anti-EGFR therapy.

Most-Reported Side Effects for Fruquintinib

From FAERS, the FDA’s public side-effect reporting system (3,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 470 reports
Colorectal cancer metastatic 388 reports
Colon cancer 371 reports
Diarrhea 275 reports
Blood pressure increased 269 reports
See full Fruquintinib drug information
Keep checking

Other Drugs & Fumitory

Browse every other medication we’ve checked against Fumitory — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fumitory against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fumitory list.

See the full Fumitory interactions page
See every supplement checked against Fruquintinib, ranked by severity
Evidence & sources

Fumitory References

The 1 sources that drive our Fumitory monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Fumitory is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Fumitory — MedlinePlus / RxList Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fumitory and Fruquintinib Together: Common Questions

Is it safe to take Fumitory with Fruquintinib?
We do not list a known interaction between Fumitory and Fruquintinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Fruquintinib interact with any supplements?
Yes. Fruquintinib has documented interactions with 168 supplements in our database — Fumitory is not one of them. The Fruquintinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fumitory monograph Uses, safety profile, and every drug interaction in one place Fruquintinib drug information The full plain-English guide to this medication Fruquintinib supplement interactions Every supplement checked against Fruquintinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fruquintinib and Fumitory?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.