Drug & supplement interaction

Gamma-aminobutyric Acid (gaba) + Factor 7a

Factor 7a brand name: NovoSeven RT.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Gamma-aminobutyric Acid (gaba) and Factor 7a in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Gamma-aminobutyric Acid (gaba) and Factor 7a

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Factor 7a and Gamma-aminobutyric Acid (gaba) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gamma-aminobutyric Acid (gaba) safety at a glance

Gamma-aminobutyric... overall Use caution Often well tolerated short-term, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety information; avoid unless your doctor advises otherwise.
Breastfeeding Avoid Not enough safety information; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Factor 7a and Gamma-aminobutyric Acid (gaba)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Gamma-aminobutyric Acid (gaba) Does Interact With Other Medications

Gamma-aminobutyric Acid (gaba) has 172 moderate, 247 minor known drug interactions in our database — Factor 7a isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 Minor 247 No known interaction 2,411 (incl. Factor 7a)
Taking anything else?

Check Another of Your Medications Against Gamma-aminobutyric Acid (gaba)

Covers the 2,830 medications we’ve checked against Gamma-aminobutyric Acid (gaba). Pick one to open its full report.

What to actually watch for

What Gamma-aminobutyric Acid (gaba) Itself Has Been Linked To

This is not an interaction — nothing below involves Factor 7a. It is the side-effect record for Gamma-aminobutyric Acid (gaba) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Gamma-aminobutyric Acid (gaba), this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Muscle weakness Worth acting on Additional detail

    “Orally, GABA seems to be generally well tolerated. Sublingually, no adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Drowsiness, gastric upset, minor throat burning, muscle weakness, and nausea.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in nausea and vomiting.

  • Seizures Worth acting on Additional detail

    “Orally, GABA may cause drowsiness, headache, or tiredness. Four children with cerebral palsy taking GABA had convulsions, and an unspecified number experienced motor restlessness. However, causality of these adverse effects was not clear, and the dose of GABA was not specified. Intravenously, GABA 50 mg has been associated with a "lack of alertness" in healthy female volunteers.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in cerebral palsy.

    5 sources cited
    1. 5115. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
    2. 19364. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
    3. 112830. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed
    4. 19362. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
    5. 51159. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  • Changes to your period Additional detail

    “In one study, one patient treated with oral GABA and phosphatidylserine reported transient amenorrhea.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in amenorrhea.

    1 source cited
    1. 19364. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  • Drowsiness Additional detail

    Recorded for Gamma-aminobutyric Acid (gaba) in the same Natural Medicines adverse-effect record shown under Muscle weakness above.

  • Anxiety or restlessness Additional detail

    “Intravenously, GABA 0.1-1.0 mg/kg has been shown to induce anxiety, dysphoria, and mood disturbances in a dose-dependent manner.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 5116. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  • Reduced appetite / Constipation Additional detail

    “Orally, minor throat burning has been associated with GABA in one study. In another study in which GABA was administered with phosphatidylserine, one patient experienced severe gastric distress, two patients reported moderate nausea, and one reported constipation. Children with cerebral palsy taking GABA experienced nausea and decreased appetite.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in cerebral palsy.

    3 sources cited
    1. 5115. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
    2. 19364. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
    3. 19362. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  • Tiredness / Headache Additional detail

    Recorded for Gamma-aminobutyric Acid (gaba) in the same Natural Medicines adverse-effect record shown under Seizures above.

  • Nausea Additional detail

    Recorded for Gamma-aminobutyric Acid (gaba) in the same Natural Medicines adverse-effect record shown under Muscle weakness above.

Everything above comes from the Natural Medicines adverse-effect record for Gamma-aminobutyric Acid (gaba) — expand a row for the licensed statement it rests on. We haven’t matched Factor 7a to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Factor 7a.

One more smart check

Taking Gamma-aminobutyric Acid (gaba) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,760 real supplement products containing Gamma-aminobutyric Acid (gaba), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gamma-aminobutyric Acid (gaba). Even though Gamma-aminobutyric Acid (gaba) itself has no known interaction with Factor 7a, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gamma-aminobutyric Acid (gaba) and Factor 7a Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamma-aminobutyric Acid (gaba)
Top 10%

#111 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Factor 7a
Top 10%

#171 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gamma-aminobutyric Acid (gaba) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Gamma-aminobutyric Acid (gaba) and Factor 7a records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gamma-aminobutyric Acid (gaba)

What is Gamma-aminobutyric Acid (gaba)?

Gamma-aminobutyric Acid (gaba)
  • Anxiety and stress
  • Sleep problems
  • Relaxation
  • High blood pressure
  • Mood support

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplements is limited and mixed, partly because it is unclear how much swallowed GABA actually reaches the brain. It is generally well tolerated short-term, but talk with a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or take other medicines.

Not a plant; an amino acid/neurotransmitter (made naturally in the body and produced for supplements by fermentation) · Capsules, tablets, powders, chewable tablets, gummies, drink mixes

An interaction check asks whether these two react with each other — it does not ask whether Gamma-aminobutyric Acid (gaba) is a good idea for someone in your situation. Here is what our Gamma-aminobutyric Acid (gaba) record says about it on its own.

Gamma-aminobutyric Acid (gaba): dosing

There is no official or standardized dose for GABA supplements. Amounts used in studies have varied widely, and there is not enough strong evidence to recommend a specific dose.The safest approach is to follow the directions on the product label and start with the lowest suggested amount.

From our Gamma-aminobutyric Acid (gaba) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gamma-aminobutyric Acid (gaba) monograph & all interactions
Keep checking

Other Drugs & Gamma-aminobutyric Acid (gaba)

Browse every other medication we’ve checked against Gamma-aminobutyric Acid (gaba) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
247Minor
2,410No known interaction
172 Moderate 247 Minor 2,410 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Gamma-aminobutyric Acid (gaba) page.

Minor

247 interactions

Showing 60 of 247 minor interactions — see all 247 on the Gamma-aminobutyric Acid (gaba) page.

No interaction 2,410 drugs checked — show the list

We also checked Gamma-aminobutyric Acid (gaba) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,410 medications checked with no known interaction — see the full Gamma-aminobutyric Acid (gaba) list.

See the full Gamma-aminobutyric Acid (gaba) interactions page
See every supplement checked against Factor 7a, ranked by severity
Evidence & sources

Gamma-aminobutyric Acid (gaba) References

The 12 references that drive our Gamma-aminobutyric Acid (gaba) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gamma-aminobutyric Acid (gaba) and Factor 7a Together: Common Questions

Is it safe to take Gamma-aminobutyric Acid (gaba) with Factor 7a?
We do not list a known interaction between Gamma-aminobutyric Acid (gaba) and Factor 7a. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Gamma-aminobutyric Acid (gaba) interact with any other medications?
Yes. Gamma-aminobutyric Acid (gaba) has 419 documented drug interactions in our database — Factor 7a is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gamma-aminobutyric Acid (gaba) monograph Uses, safety profile, and every drug interaction in one place Factor 7a supplement interactions Every supplement checked against Factor 7a, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.