Drug & supplement interaction

Gamma-aminobutyric Acid (gaba) + Amphetamine

Amphetamine brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Gamma-aminobutyric Acid (gaba) and Amphetamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Gamma-aminobutyric Acid (gaba) and Amphetamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amphetamine and Gamma-aminobutyric Acid (gaba) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gamma-aminobutyric Acid (gaba) safety at a glance

Gamma-aminobutyric... overall Use caution Often well tolerated short-term, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety information; avoid unless your doctor advises otherwise.
Breastfeeding Avoid Not enough safety information; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amphetamine and Gamma-aminobutyric Acid (gaba)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Amphetamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Amphetamine is filed under 6 classifications — including monoamine oxidase inhibitors (maois), amphetamines, stimulant drugs. Gamma-aminobutyric Acid (gaba) has documented interactions with 2 drug classes — the most serious being antihypertensive drugs (moderate) and cns depressants (minor) — and none of Amphetamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gamma-aminobutyric Acid (gaba) Does Interact With Other Medications

Gamma-aminobutyric Acid (gaba) has 172 moderate, 247 minor known drug interactions in our database — Amphetamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 Minor 247 No known interaction 2,411 (incl. Amphetamine)
Taking anything else?

Check Another of Your Medications Against Gamma-aminobutyric Acid (gaba)

Covers the 2,830 medications we’ve checked against Gamma-aminobutyric Acid (gaba). Pick one to open its full report.

What to actually watch for

What Gamma-aminobutyric Acid (gaba) Itself Has Been Linked To

This is not an interaction — nothing below involves Amphetamine. It is the side-effect record for Gamma-aminobutyric Acid (gaba) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Gamma-aminobutyric Acid (gaba), this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Muscle weakness Worth acting on Additional detail

    “Orally, GABA seems to be generally well tolerated. Sublingually, no adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Drowsiness, gastric upset, minor throat burning, muscle weakness, and nausea.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in nausea and vomiting.

  • Seizures Worth acting on Additional detail

    “Orally, GABA may cause drowsiness, headache, or tiredness. Four children with cerebral palsy taking GABA had convulsions, and an unspecified number experienced motor restlessness. However, causality of these adverse effects was not clear, and the dose of GABA was not specified. Intravenously, GABA 50 mg has been associated with a "lack of alertness" in healthy female volunteers.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in cerebral palsy.

    5 sources cited
    1. 5115. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
    2. 19364. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
    3. 112830. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed
    4. 19362. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
    5. 51159. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  • Changes to your period Additional detail

    “In one study, one patient treated with oral GABA and phosphatidylserine reported transient amenorrhea.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in amenorrhea.

    1 source cited
    1. 19364. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  • Drowsiness Additional detail

    Recorded for Gamma-aminobutyric Acid (gaba) in the same Natural Medicines adverse-effect record shown under Muscle weakness above.

  • Anxiety or restlessness Additional detail

    “Intravenously, GABA 0.1-1.0 mg/kg has been shown to induce anxiety, dysphoria, and mood disturbances in a dose-dependent manner.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 5116. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  • Reduced appetite / Constipation Additional detail

    “Orally, minor throat burning has been associated with GABA in one study. In another study in which GABA was administered with phosphatidylserine, one patient experienced severe gastric distress, two patients reported moderate nausea, and one reported constipation. Children with cerebral palsy taking GABA experienced nausea and decreased appetite.”

    Gamma-aminobutyric Acid (gaba) · Natural Medicines adverse-effect record, reported in cerebral palsy.

    3 sources cited
    1. 5115. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
    2. 19364. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
    3. 19362. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  • Tiredness / Headache Additional detail

    Recorded for Gamma-aminobutyric Acid (gaba) in the same Natural Medicines adverse-effect record shown under Seizures above.

  • Nausea Additional detail

    Recorded for Gamma-aminobutyric Acid (gaba) in the same Natural Medicines adverse-effect record shown under Muscle weakness above.

Everything above comes from the Natural Medicines adverse-effect record for Gamma-aminobutyric Acid (gaba) — expand a row for the licensed statement it rests on. We haven’t matched Amphetamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Amphetamine.

Overlapping uses

What Amphetamine Is Prescribed For, and What Gamma-aminobutyric Acid (gaba) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Amphetamine is a prescription medicine with approved uses on its FDA label. Gamma-aminobutyric Acid (gaba) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Amphetamine is prescribed for: Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group. Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

Gamma-aminobutyric Acid (gaba) has been studied for:

  • Obesity studied, not established Gamma-aminobutyric Acid (gaba) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Gamma-aminobutyric Acid (gaba) for obesity

    Although there has been interest in using oral and sublingual GABA for weight loss, there is insufficient reliable information about the clinical effects of GABA for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amphetamine on your own; if you are taking Gamma-aminobutyric Acid (gaba) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Gamma-aminobutyric Acid (gaba) or Amphetamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Gamma-aminobutyric Acid (gaba) or Amphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amphetamine

This page covers Gamma-aminobutyric Acid (gaba) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amphetamine page lists 130 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 16 major · 97 moderate · 17 minor.

From our pharmacist’s overview on the Amphetamine page

“Amphetamine (Dyanavel XR, Adzenys ER, Mydayis) is a prescription stimulant, usually taken for ADHD, and its interaction list is one to approach with genuine care. Of the 130 supplements and herbal ingredients on file, 16 carry a major rating, and many of those work the same way, either inhibiting monoamine oxidase, as yohimbe does, or…”

Reviewed by 2 · Jul 18, 2026

Open the Amphetamine interaction page

One more smart check

Taking Gamma-aminobutyric Acid (gaba) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,760 real supplement products containing Gamma-aminobutyric Acid (gaba), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gamma-aminobutyric Acid (gaba). Even though Gamma-aminobutyric Acid (gaba) itself has no known interaction with Amphetamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gamma-aminobutyric Acid (gaba) and Amphetamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamma-aminobutyric Acid (gaba)
Top 10%

#107 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amphetamine
Top 1%

#28 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gamma-aminobutyric Acid (gaba) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Gamma-aminobutyric Acid (gaba) and Amphetamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gamma-aminobutyric Acid (gaba)

What is Gamma-aminobutyric Acid (gaba)?

Gamma-aminobutyric Acid (gaba)
  • Anxiety and stress
  • Sleep problems
  • Relaxation
  • High blood pressure
  • Mood support

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplements is limited and mixed, partly because it is unclear how much swallowed GABA actually reaches the brain. It is generally well tolerated short-term, but talk with a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or take other medicines.

Not a plant; an amino acid/neurotransmitter (made naturally in the body and produced for supplements by fermentation) · Capsules, tablets, powders, chewable tablets, gummies, drink mixes

An interaction check asks whether these two react with each other — it does not ask whether Gamma-aminobutyric Acid (gaba) is a good idea for someone in your situation. Here is what our Gamma-aminobutyric Acid (gaba) record says about it on its own.

Gamma-aminobutyric Acid (gaba): dosing

There is no official or standardized dose for GABA supplements. Amounts used in studies have varied widely, and there is not enough strong evidence to recommend a specific dose.The safest approach is to follow the directions on the product label and start with the lowest suggested amount.

From our Gamma-aminobutyric Acid (gaba) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gamma-aminobutyric Acid (gaba) monograph & all interactions
Medication

About Amphetamine

What Is Amphetamine Used For?

Brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER

Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group.

Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

Most-Reported Side Effects for Amphetamine

From FAERS, the FDA’s public side-effect reporting system (50,216 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 3,508 reports
Nausea 3,143 reports
Headache 2,923 reports
Anxiety 2,703 reports
Toxicity to various agents 2,287 reports
See full Amphetamine drug information
Keep checking

Other Drugs & Gamma-aminobutyric Acid (gaba)

Browse every other medication we’ve checked against Gamma-aminobutyric Acid (gaba) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
247Minor
2,410No known interaction
172 Moderate 247 Minor 2,410 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Gamma-aminobutyric Acid (gaba) page.

Minor

247 interactions

Showing 60 of 247 minor interactions — see all 247 on the Gamma-aminobutyric Acid (gaba) page.

No interaction 2,410 drugs checked — show the list

We also checked Gamma-aminobutyric Acid (gaba) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,410 medications checked with no known interaction — see the full Gamma-aminobutyric Acid (gaba) list.

See the full Gamma-aminobutyric Acid (gaba) interactions page
See every supplement checked against Amphetamine, ranked by severity
Evidence & sources

Gamma-aminobutyric Acid (gaba) References

The 12 references that drive our Gamma-aminobutyric Acid (gaba) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gamma-aminobutyric Acid (gaba) and Amphetamine Together: Common Questions

Is it safe to take Gamma-aminobutyric Acid (gaba) with Amphetamine?
We do not list a known interaction between Gamma-aminobutyric Acid (gaba) and Amphetamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Gamma-aminobutyric Acid (gaba) and Amphetamine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Gamma-aminobutyric Acid (gaba) in each. That is a conversation for your prescriber, especially if Amphetamine is being adjusted to a target.
How was the Gamma-aminobutyric Acid (gaba) and Amphetamine combination checked?
Interactions in our licensed database are recorded against drug classes. Amphetamine is filed under 6 classifications, and Gamma-aminobutyric Acid (gaba) has documented interactions with 2 drug classes — none of Amphetamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gamma-aminobutyric Acid (gaba) interact with any other medications?
Yes. Gamma-aminobutyric Acid (gaba) has 419 documented drug interactions in our database — Amphetamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Amphetamine interact with any supplements?
Yes. Amphetamine has documented interactions with 130 supplements in our database — Gamma-aminobutyric Acid (gaba) is not one of them. The Amphetamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gamma-aminobutyric Acid (gaba) monograph Uses, safety profile, and every drug interaction in one place Amphetamine drug information The full plain-English guide to this medication Amphetamine supplement interactions Every supplement checked against Amphetamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amphetamine and Gamma-aminobutyric Acid (gaba)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.