Germanium + Ketoprofen
Ketoprofen brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection.
We found no known interaction between Germanium and Ketoprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ketoprofen states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Germanium and Ketoprofen
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ketoprofen and Germanium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Germanium at all — not against Ketoprofen, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Germanium safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Germanium in Pregnancy & Breastfeeding
When used orally due to reported toxicity; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Ketoprofen Products Have a Food Rule — Germanium Should Not Break It
At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Germanium on an empty stomach out of habit, keep them separate — and take Ketoprofen with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ketoprofen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Although food delays the absorption of both formulations (see CLINICAL PHARMACOLOGY ) in most of the clinical trials ketoprofen was taken with food or milk.
From the Dosage and Administration section of the FDA label we read for Ketoprofen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Ketoprofen
This page covers Germanium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoprofen page lists 252 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).
By severity: 7 major · 217 moderate · 28 minor.
From our pharmacist’s overview on the Ketoprofen page
“Bleeding is what worries me most with ketoprofen (Orudis, Oruvail Gel). As an NSAID, it already irritates the stomach lining and slows clotting, and 202 of the 252 supplements and herbs on this page can push that bleeding risk further.”
Reviewed by 2 · Jul 18, 2026
Taking Germanium as Part of a Dietary Supplement Product? Check It for Interactions
We hold 41 real supplement products containing Germanium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Germanium. Even though Germanium itself has no known interaction with Ketoprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Germanium and Ketoprofen Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#852 of 1,452 supplements looked up here in the last 7 days
#946 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Germanium reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Germanium and Ketoprofen records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Germanium
What is Germanium?
- Immune support
- Cancer (unproven, alternative therapy)
- Antioxidant claims
- Pain relief
- General wellness/anti-aging
Germanium is a chemical element sometimes sold as a dietary supplement, but there is no reliable evidence it treats any disease. More importantly, germanium supplements have been linked to serious and sometimes fatal kidney damage, so health authorities have warned against their use. We do not recommend taking germanium supplements.
Not a plant; germanium is a chemical element (mineral) · Capsules, tablets, powders (often as germanium-132 / organic germanium or inorganic germanium salts)
An interaction check asks whether these two react with each other — it does not ask whether Germanium is a good idea for someone in your situation. Here is what our Germanium record says about it on its own.
Germanium: dosing
There is no safe or established dose of germanium as a dietary supplement, and we do not recommend taking it at all.
From our Germanium monograph — the full record covers uses, side effects and every documented interaction.
About Ketoprofen
What Is Ketoprofen Used For?
Brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection
Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods).
Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.
Most-Reported Side Effects for Ketoprofen
From FAERS, the FDA’s public side-effect reporting system (13,040 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Germanium
Browse every other medication we’ve checked against Germanium — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Germanium against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Germanium list.
Germanium References
The 30 references that drive our Germanium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Tao SH, Bolger, PM. Hazard assessment of germanium supplements. Regul Toxicol Pharmacol 1997;25:211-9.
- Budman DR, Schulman P, Vinciguerra V, Degnan TJ. Phase I trial of spirogermanium given by infusion in a multiple-dose schedule. Cancer Treat Rep 1982;66:173-5..
- Mainwaring MG, Poor C, Zander DS, Harman E. Complete remission of pulmonary spindle cell carcinoma after treatment with oral germanium sesquioxide. Chest 2000;117:591-3.. PubMed
- Vogelzang NJ, Gesme DH, Kennedy BJ. A phase II study of spirogermanium in advanced human malignancy. Am J Clin Oncol 1985;8:341-4.. PubMed
- Ettinger DS, Finkelstein DM, Donehower RC, et al. Phase II study of N-methylformamide, spirogermanium, and 4-demethoxydaunorubicin in the treatment of non-small cell lung cancer (EST 3583): an Eastern Cooperative Oncology Group study. Med Pediatr Oncol 1 PubMed
- Higuchi I, Izumo S, Kuriyama M, et al. Germanium myopathy: clinical and experimental pathological studies. Acta Neuropathol (Berl) 1989;79:300-4.. PubMed
- Matsusaka T, Fujii M, Nakano T, et al. Germanium-induced nephropathy: report of two cases and review of the literature. Clin Nephrol 1988;30:341-5..
- Hess B, Raisin J, Zimmermann A, et al. Tubulointerstitial nephropathy persisting 20 months after discontinuation of chronic intake of germanium lactate citrate. Am J Kidney Dis 1993;21:548-52.. PubMed
- Luck BE, Mann H, Melzer H, et al. Renal and other organ failure caused by germanium intoxication. Nephrol Dial Transplant 1999;14:2464-8. PubMed
- Schauss AG. Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide. Biol Trace Elem Res 1991;29:267-80.. PubMed
- Schein PS, Slavik M, Smythe T, et al. Phase I clinical trial of spirogermanium. Cancer Treat Rep 1980;64:1051-6..
- Trope C, Mattsson W, Gynning I, et al. Phase II study of spirogermanium in advanced ovarian malignancy. Cancer Treat Rep 1981;65:119-20..
- Gerber GB, Leonard A. Mutagenicity, carcinogenicity and teratogenicity of germanium compounds. Mutat Res 1997;387:141-6.. PubMed
- Asaka T, Nitta E, Makifuchi T, et al. Germanium intoxication with sensory ataxia. J Neurol Sci 1995;130:220-3.. PubMed
- Sanai T, Okuda S, Onoyama K, et al. Germanium dioxide-induced nephropathy: a new type of renal disease. Nephron. 1990;54:53-60.. PubMed
- Krapf R, Schaffner T, Iten PX. Abuse of germanium associated with fatal lactic acidosis. Nephron 1992;62:351-6.. PubMed
- Takeuchi A, Yoshizawa N, Oshima S, et al. Nephrotoxicity of germanium compounds: report of a case and review of the literature. Nephron 1992;60:436-42.. PubMed
- Luck, B. E., Mann, H., Melzer, H., Dunemann, L., and Begerow, J. Renal and other organ failure caused by germanium intoxication. Nephrol.Dial.Transplant. 1999;14(10):2464-2468. PubMed
- Hirayama, C., Suzuki, H., Ito, M., Okumura, M., and Oda, T. Propagermanium: a nonspecific immune modulator for chronic hepatitis B. J Gastroenterol. 2003;38(6):525-532. PubMed
- Tsutsumi, Y., Tanaka, J., Kanamori, H., Musashi, M., Minami, H., Fukushima, A., Yamato, H., Ehira, N., Kawamura, T., Obara, S., Ogura, N., Asaka, M., Imamura, M., and Masauzi, N. Effectiveness of propagermanium treatment in multiple myeloma patients. Eur. PubMed
- Fujimoto, M., Ishibashi, H., Shimamura, R., Takahashi, K., Hirata, Y., Kudo, J., Niho, Y., Kira, J., and Miyata, K. [A patient with liver cirrhosis manifesting various symptoms including cerebellar ataxia due to germanium intoxication]. Fukuoka Igaku Zass
- Raisin, J., Hess, B., Blatter, M., Zimmermann, A., Descoeudres, C., Horber, F. F., and Jaeger, P. [Toxicity of an organic Germanium compound: deleterious consequences of a "natural remedy"]. Schweiz.Med.Wochenschr. 1-8-1992;122(1-2):11-13.
- Kamijo, M., Yagihashi, S., Kida, K., Narita, S., and Nakata, F. [An autopsy case of chronic germanium intoxication presenting peripheral neuropathy, spinal ataxia, and chronic renal failure]. Rinsho Shinkeigaku 1991;31(2):191-196.
- Obara, K., Saito, T., Sato, H., Yamakage, K., Watanabe, T., Kakizawa, M., Tsukamoto, T., Kobayashi, K., Hongo, M., and Yoshinaga, K. Germanium poisoning: clinical symptoms and renal damage caused by long-term intake of germanium. Jpn.J.Med. 1991;30(1):67- PubMed
- Van der Spoel, J. I., Stricker, B. H., Schipper, M. E., de Bruijn, W., de Smet, P. A., and Esseveld, M. R. [Toxic damage of kidney, liver and muscle attributed to the administration of germanium-lactate-citrate]. Ned.Tijdschr.Geneeskd. 6-22-1991;135(25):1
- Schauss, A. G. Nephrotoxicity in humans by the ultratrace element germanium. Ren Fail. 1991;13(1):1-4. PubMed
- Iijima, M., Mugishima, M., Takeuchi, M., Uchiyama, S., Kobayashi, I., and Maruyama, S. [A case of inorganic germanium poisoning with peripheral and cranial neuropathy, myopathy and autonomic dysfunction]. No To Shinkei 1990;42(9):851-856.
- Nagata, N., Yoneyama, T., Yanagida, K., Ushio, K., Yanagihara, S., Matsubara, O., and Eishi, Y. Accumulation of germanium in the tissues of a long-term user of germanium preparation died of acute renal failure. J.Toxicol.Sci. 1985;10(4):333-341. PubMed
- Woolley, P. V., Ahlgren, J. D., Byrne, P. J., Priego, V. M., and Schein, P. S. A Phase I trial of spirogermanium administered on a continuous infusion schedule. Invest New Drugs 1984;2(3):305-309. PubMed
- Wang L, Zheng C, Zhao D. Successful management of germanium poisoning-induced multiple organ dysfunctions by combined blood purification therapy. Curr Med Res Opin. 2020 Apr;36(4):687-691. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Ketoprofen Is Linked to Lower Levels of One Nutrient
Natural Medicines records Ketoprofen as a medicine that can lower these. This is not an interaction with Germanium — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Ketoprofen nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Germanium and Ketoprofen Together: Common Questions
Is it safe to take Germanium with Ketoprofen?
Do Germanium and Ketoprofen have any of the same side effects?
Should I take Germanium and Ketoprofen at the same time of day?
Does Ketoprofen interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Ketoprofen and Germanium?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.