Glucuronolactone + Enasidenib
Enasidenib brand name: Idhifa.
We found no known interaction between Glucuronolactone and Enasidenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Glucuronolactone and Enasidenib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Enasidenib and Glucuronolactone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Glucuronolactone at all — not against Enasidenib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Glucuronolactone safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Enasidenib
This page covers Glucuronolactone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enasidenib page lists 203 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).
By severity: 3 major · 156 moderate · 44 minor.
From our pharmacist’s overview on the Enasidenib page
“Anyone taking enasidenib (Idhifa) for acute myeloid leukemia should treat this supplement list with genuine care, beginning with the major-rated entries: grapefruit, St. John's wort, and activated charcoal.”
Reviewed by 2 · Jul 18, 2026
Taking Glucuronolactone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 478 real supplement products containing Glucuronolactone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Glucuronolactone. Even though Glucuronolactone itself has no known interaction with Enasidenib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Glucuronolactone and Enasidenib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#272 of 1,452 supplements looked up here in the last 7 days
#2,467 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Glucuronolactone is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Glucuronolactone reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Glucuronolactone and Enasidenib records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Glucuronolactone
What is Glucuronolactone?
- Energy and stamina
- Mental focus and alertness
- Reducing fatigue
- Athletic performance
- Detoxification support (traditional belief)
Glucuronolactone is a naturally occurring compound that is commonly added to energy drinks and supplements, often alongside caffeine and taurine. There is very little solid human evidence that it provides energy, focus, or other benefits on its own, and most studies tested it only as part of a combined product. It appears reasonably well tolerated at the amounts used in drinks, but its long-term safety and effects in pregnancy and breastfeeding are not well studied.
Not a plant; a manufactured/naturally occurring compound (D-glucuronolactone) · Energy drinks, capsules, powders, pre-workout blends
An interaction check asks whether these two react with each other — it does not ask whether Glucuronolactone is a good idea for someone in your situation. Here is what our Glucuronolactone record says about it on its own.
Glucuronolactone: dosing
There is no officially established or standardized dose of glucuronolactone for any health purpose. In energy drinks it commonly appears in amounts of a few hundred milligrams per serving, often alongside caffeine and taurine.Because a proven effective dose has not been identified, the best advice is to follow the product label and not exceed it.
From our Glucuronolactone monograph — the full record covers uses, side effects and every documented interaction.
About Enasidenib
What Is Enasidenib Used For?
Brand name: Idhifa
Idhifa (enasidenib) is used to treat adult patients with acute myeloid leukemia (AML) — a fast-moving cancer of the blood and bone marrow — whose disease has come back after treatment (relapsed) or has stopped responding to treatment (refractory). It is specifically for patients whose leukemia has a mutation in the IDH2 gene, which must be confirmed by an FDA-approved test before starting therapy.
Other Drugs & Glucuronolactone
Browse every other medication we’ve checked against Glucuronolactone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Glucuronolactone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Glucuronolactone list.
Glucuronolactone References
The 2 sources that drive our Glucuronolactone monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Glucuronolactone is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Caffeine and Energy Drinks — NIH National Center for Complementary and Integrative Health Source
- Caffeine — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Glucuronolactone and Enasidenib Together: Common Questions
Is it safe to take Glucuronolactone with Enasidenib?
Does Enasidenib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Enasidenib and Glucuronolactone?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.