Drug & supplement interaction

Goa Powder + Guanabenz Acetate

Guanabenz Acetate brand name: Wytensin.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Goa Powder and Guanabenz Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Goa Powder and Guanabenz Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Guanabenz Acetate and Goa Powder in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Goa Powder at all — not against Guanabenz Acetate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Goa Powder safety at a glance

Goa Powder overall Use caution It is a strong skin irritant meant only for external use and can be toxic if swallowed.
Pregnancy Avoid Safety has not been established, so avoid use during pregnancy.
Breastfeeding Avoid Safety has not been established, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Guanabenz Acetate and Goa Powder? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Goa Powder Itself Has Been Linked To

This is not an interaction — nothing below involves Guanabenz Acetate. It is the side-effect record for Goa Powder on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Goa Powder, this list is the first place to look.

  • Swelling Additional detail

    “Topically, application of goa powder can cause redness, swelling, pustules, and conjunctivitis (18).”

    Goa Powder · Natural Medicines adverse-effect record, reported in conjunctivitis.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Diarrhea / Vomiting Additional detail

    “Goa powder can cause vomiting and diarrhea when taken orally or absorbed through the skin (18).”

    Goa Powder · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Goa Powder — expand a row for the licensed statement it rests on. We haven’t matched Guanabenz Acetate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Guanabenz Acetate.

Everything else you take

See Every Supplement That Interacts With Guanabenz Acetate

This page covers Goa Powder only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guanabenz Acetate page lists 137 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 112 moderate · 21 minor.

From our pharmacist’s overview on the Guanabenz Acetate page

“Guanabenz acetate (Wytensin) is an older blood pressure medicine, and the 137 supplements on file call for genuine vigilance, beginning with the four rated major. Two are toxic plants that can strain the heart or swing pressure hard, one is tyramine, found in aged cheeses and cured meats, which fights the drug's effect, and one is acti…”

Reviewed by 2 · Jul 18, 2026

Open the Guanabenz Acetate interaction page

How much people look this up

Where Goa Powder and Guanabenz Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goa Powder
Steady interest

#1,240 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Guanabenz Acetate
Steady interest

#1,745 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Goa Powder reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Goa Powder and Guanabenz Acetate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Goa Powder

What is Goa Powder?

  • Psoriasis (topical)
  • Ringworm and other fungal skin infections
  • Scaly skin conditions
  • Eczema-like rashes

Goa powder (also called araroba) is a natural source of chrysarobin, a substance historically used on the skin for psoriasis and fungal infections. It is a harsh, irritating chemical that is mostly of historical interest today, and it should never be swallowed. If you are considering anything containing chrysarobin or anthralin, talk with a doctor or pharmacist first.

Andira araroba · Fabaceae · A yellow powder (chrysarobin) extracted from the wood and trunk cavities of the araroba tree · Topical ointments, pastes, and creams; historically a raw powder

An interaction check asks whether these two react with each other — it does not ask whether Goa Powder is a good idea for someone in your situation. Here is what our Goa Powder record says about it on its own.

Goa Powder: dosing

There is no established or standardized dose for Goa powder as a supplement. Historically it was mixed into ointments at concentrations chosen by a pharmacist or physician, and even then it had to be used carefully because of irritation and staining.If you encounter a product that contains chrysarobin or the related medicine anthralin, follow the product label exactly and do not apply more than directed. Because this is a potent and irritating substance, it is best to use it only under the guidance of a doctor or pharmacist.

From our Goa Powder monograph — the full record covers uses, side effects and every documented interaction.

Read the full Goa Powder monograph & all interactions
Medication

About Guanabenz

What Is Guanabenz Used For?

Brand name: Wytensin

  • Guanabenz is used to treat high blood pressure. It is in a class of medications called centrally acting alpha2A-adrenergic receptor agonists. Guanabenz works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body.

  • High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

See full Guanabenz drug information
Keep checking

Other Drugs & Goa Powder

Browse every other medication we’ve checked against Goa Powder — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Goa Powder References

The 1 references that drive our Goa Powder monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Goa Powder and Guanabenz Acetate Together: Common Questions

Is it safe to take Goa Powder with Guanabenz Acetate?
We do not list a known interaction between Goa Powder and Guanabenz Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Guanabenz Acetate interact with any supplements?
Yes. Guanabenz Acetate has documented interactions with 137 supplements in our database — Goa Powder is not one of them. The Guanabenz Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Guanabenz Acetate and Goa Powder?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.