Drug & supplement interaction

Graviola + Empagliflozin

Empagliflozin brand name: Jardiance.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Graviola and Empagliflozin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Graviola and Empagliflozin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Empagliflozin and Graviola in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Graviola safety at a glance

Graviola overall Use caution Human safety data are limited, and lab studies raise concerns about possible nerve toxicity with long-term use.
Pregnancy Possibly Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Empagliflozin and Graviola? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Empagliflozin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Empagliflozin is filed under 3 classifications — including antidiabetes drugs, oral drugs. Graviola has documented interactions with 1 drug class — the most serious being carbamazepine (tegretol) (moderate) — and none of Empagliflozin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Graviola Does Interact With Other Medications

Graviola has 1 moderate known drug interaction in our database — Empagliflozin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Empagliflozin)
Taking anything else?

Check Another of Your Medications Against Graviola

Covers the 2,830 medications we’ve checked against Graviola. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Graviola and Empagliflozin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 5.4% of FDA reports for Empagliflozin Additional detail

    Graviola

    “In one clinical study, some patients reported nausea and burning pain in the epigastrium after taking graviola leaf extract 300 mg daily.”

    Graviola · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 95045. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed

    Empagliflozin

    Listed in the ADVERSE REACTIONS section of the FDA label for Empagliflozin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Empagliflozin come from the ADVERSE REACTIONS section of its FDA label; effects for Graviola come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 71,563 voluntary FDA FAERS reports for Empagliflozin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Graviola in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Empagliflozin Is Prescribed For, and What Graviola Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Empagliflozin is a prescription medicine with approved uses on its FDA label. Graviola is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Empagliflozin is prescribed for: Jardiance (empagliflozin) tablets are approved for several important uses in adults. It reduces the risk of cardiovascular death and hospitalization in adults with heart failure. It also slows the progression of chronic kidney disease by reducing the risk of serious kidney decline, end-stage kidney disease, cardiovascular death, and hospitalization. In adults with type 2 diabetes and established cardiovascular disease, Jardiance reduces the risk of cardiovascular death.

Read the rest of what Empagliflozin is prescribed for

Jardiance is also used — alongside diet and exercise — to improve blood sugar control in type 2 diabetes in adults and children aged 10 and older. It is not recommended for blood sugar control in type 1 diabetes (it may raise the risk of a dangerous condition called diabetic ketoacidosis) or in type 2 diabetes patients with severely reduced kidney function.

Graviola has been studied for:

  • Diabetes studied, not established Graviola has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Graviola for diabetes

    Although there has been interest in using oral graviola for diabetes, there is insufficient reliable information about the clinical effects of graviola for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Empagliflozin on your own; if you are taking Graviola for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Graviola or Empagliflozin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Graviola or Empagliflozin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Empagliflozin

This page covers Graviola only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Empagliflozin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 216 moderate · 39 minor.

From our pharmacist’s overview on the Empagliflozin page

“Almost everything on this page can nudge blood sugar in someone taking empagliflozin (Jardiance) for type 2 diabetes, heart failure, or kidney protection, and two entries deserve genuine caution before anything else. Siberian cocklebur has caused severe low blood sugar in humans and should not be combined with any glucose-lowering medi…”

Reviewed by 2 · Jul 18, 2026

Open the Empagliflozin interaction page

One more smart check

Taking Graviola as Part of a Dietary Supplement Product? Check It for Interactions

We hold 217 real supplement products containing Graviola, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Graviola. Even though Graviola itself has no known interaction with Empagliflozin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Graviola and Empagliflozin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Graviola
Top half

#637 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Empagliflozin
Top 25%

#545 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Graviola reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Graviola and Empagliflozin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Graviola

What is Graviola?

  • Cancer support (unproven)
  • Infections
  • Inflammation
  • High blood pressure
  • Digestive complaints
  • Diabetes

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online claims that it fights cancer, there is no reliable human evidence that it treats or cures any disease, and animal research raises concerns that it may harm nerve cells. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Annona muricata · Annonaceae · Leaves, fruit, bark, seeds, and roots · Tea, capsules, tinctures, fruit pulp, and juice

An interaction check asks whether these two react with each other — it does not ask whether Graviola is a good idea for someone in your situation. Here is what our Graviola record says about it on its own.

Graviola: dosing

There is no established or standardized safe dose of graviola. Products vary widely in strength and in which plant part they contain.If you choose to use a graviola product, follow the directions on the label, do not exceed the recommended amount, and avoid long-term daily use.

From our Graviola monograph — the full record covers uses, side effects and every documented interaction.

Read the full Graviola monograph & all interactions
Medication

About Empagliflozin

What Is Empagliflozin Used For?

Brand name: Jardiance

Jardiance (empagliflozin) tablets are approved for several important uses in adults. It reduces the risk of cardiovascular death and hospitalization in adults with heart failure. It also slows the progression of chronic kidney disease by reducing the risk of serious kidney decline, end-stage kidney disease, cardiovascular death, and hospitalization. In adults with type 2 diabetes and established cardiovascular disease, Jardiance reduces the risk of cardiovascular death.

Jardiance is also used — alongside diet and exercise — to improve blood sugar control in type 2 diabetes in adults and children aged 10 and older. It is not recommended for blood sugar control in type 1 diabetes (it may raise the risk of a dangerous condition called diabetic ketoacidosis) or in type 2 diabetes patients with severely reduced kidney function.

Most-Reported Side Effects for Empagliflozin

From FAERS, the FDA’s public side-effect reporting system (71,563 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diabetic ketoacidosis 4,153 reports
Nausea 3,866 reports
Blood glucose increased 3,534 reports
Diarrhea 3,424 reports
Weight decreased 3,137 reports
See full Empagliflozin drug information
Keep checking

Other Drugs & Graviola

Browse every other medication we’ve checked against Graviola — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Graviola against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Graviola list.

See the full Graviola interactions page
See every supplement checked against Empagliflozin, ranked by severity
Evidence & sources

Graviola References

The 4 references that drive our Graviola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Graviola and Empagliflozin Together: Common Questions

Is it safe to take Graviola with Empagliflozin?
We do not list a known interaction between Graviola and Empagliflozin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Graviola and Empagliflozin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Graviola and Empagliflozin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Graviola in each. That is a conversation for your prescriber, especially if Empagliflozin is being adjusted to a target.
How was the Graviola and Empagliflozin combination checked?
Interactions in our licensed database are recorded against drug classes. Empagliflozin is filed under 3 classifications, and Graviola has documented interactions with 1 drug class — none of Empagliflozin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Graviola interact with any other medications?
Yes. Graviola has 1 documented drug interaction in our database — Empagliflozin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Empagliflozin interact with any supplements?
Yes. Empagliflozin has documented interactions with 257 supplements in our database — Graviola is not one of them. The Empagliflozin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Graviola monograph Uses, safety profile, and every drug interaction in one place Empagliflozin drug information The full plain-English guide to this medication Empagliflozin supplement interactions Every supplement checked against Empagliflozin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Empagliflozin and Graviola?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.