Great Plantain + Nintedanib Esylate
Nintedanib Esylate brand name: Ofev.
We found no known interaction between Great Plantain and Nintedanib Esylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Nintedanib Esylate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Great Plantain and Nintedanib Esylate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Nintedanib Esylate and Great Plantain in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Great Plantain safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Nintedanib Esylate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Nintedanib Esylate is filed under 5 classifications — including anticoagulant/antiplatelet drugs, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Great Plantain has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Nintedanib Esylate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Great Plantain Does Interact With Other Medications
Great Plantain has 2 moderate known drug interactions in our database — Nintedanib Esylate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Great Plantain
We haven’t checked that one against Great Plantain yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Great Plantain. Pick one to open its full report.
Great Plantain in Pregnancy & Breastfeeding
When used orally because it can increase uterine tone.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Nintedanib Esylate Products Have a Food Rule — Great Plantain Should Not Break It
At least one FDA label for a product containing Nintedanib Esylate says to take it with food. If you take Great Plantain on an empty stomach out of habit, keep them separate — and take Nintedanib Esylate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Nintedanib Esylate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended dosage: 150 mg taken orally twice daily approximately 12 hours apart taken with food.
From the Dosage and Administration section of the FDA label we read for Nintedanib Esylate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Nintedanib Esylate
This page covers Great Plantain only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nintedanib Esylate page lists 285 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).
By severity: 5 major · 240 moderate · 40 minor.
From our pharmacist’s overview on the Nintedanib Esylate page
“You take Ofev (nintedanib) to slow lung scarring, and this page deserves a careful read before any supplement joins it. Of the 285 ingredients here, the biggest cluster, over 200, can add to bleeding risk, a real concern since nintedanib itself can make you bleed more easily.”
Reviewed by 2 · Jul 18, 2026
Where Great Plantain and Nintedanib Esylate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,145 of 1,452 supplements looked up here in the last 7 days
#1,962 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Great Plantain reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Great Plantain and Nintedanib Esylate records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Great Plantain
What is Great Plantain?
- Minor wounds and skin irritation
- Insect bites and stings
- Coughs and sore throat
- Digestive upset
- Mild inflammation
Great Plantain is a common weed traditionally used on the skin for minor wounds and bites, and as a tea for coughs or stomach upset. Human evidence for most of these uses is limited, though the plant appears generally well tolerated. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.
Plantago major · Plantaginaceae · Leaves and seeds · Tea, capsules, tinctures, topical salves and ointments, fresh crushed leaves (poultice)
An interaction check asks whether these two react with each other — it does not ask whether Great Plantain is a good idea for someone in your situation. Here is what our Great Plantain record says about it on its own.
Great Plantain: dosing
There is no well-established standardized dose for Great Plantain. Traditional use varies widely, and the amount of active compounds differs between products and plant sources.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist or doctor can help you decide whether it is appropriate for you and review your other medications and health conditions first.
From our Great Plantain monograph — the full record covers uses, side effects and every documented interaction.
About Nintedanib
What Is Nintedanib Used For?
Brand name: Ofev
Nintedanib capsules are approved for adults with idiopathic pulmonary fibrosis (IPF) — a chronic, progressive scarring of the lungs — and for adults with chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, meaning fibrosing lung diseases that continue to worsen over time despite treatment.
Nintedanib capsules (including Ofev) are also indicated to slow the rate of decline in lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD), a lung complication of the autoimmune condition systemic sclerosis (scleroderma). Note that the Nintedanib esylate capsule product is approved for IPF and chronic fibrosing ILDs with a progressive phenotype, but SSc-ILD approval is carried by Ofev and other nintedanib capsule products — always confirm with your prescriber which product you have been prescribed.
Other Drugs & Great Plantain
Browse every other medication we’ve checked against Great Plantain — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Great Plantain against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Methotrexate ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Fluoxetine ›
- Isotretinoin ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Great Plantain list.
Great Plantain References
The 3 references that drive our Great Plantain monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Adom MB, Taher M, Mutalabisin MF, et al. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 2017;96:348-360. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Great Plantain and Nintedanib Esylate Together: Common Questions
Is it safe to take Great Plantain with Nintedanib Esylate?
Do Great Plantain and Nintedanib Esylate have any of the same side effects?
Should I take Great Plantain and Nintedanib Esylate at the same time of day?
How was the Great Plantain and Nintedanib Esylate combination checked?
Does Great Plantain interact with any other medications?
Does Nintedanib Esylate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.