Drug & supplement interaction

Hawaiian Baby Woodrose + Codeine Phosphate

Codeine Phosphate brand name: Codeine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hawaiian Baby Woodrose and Codeine Phosphate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hawaiian Baby Woodrose and Codeine Phosphate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Codeine Phosphate and Hawaiian Baby Woodrose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hawaiian Baby Woodrose safety at a glance

Hawaiian Baby Wood... overall Avoid Seeds contain LSD-like compounds and can cause serious psychological and physical effects.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Codeine Phosphate and Hawaiian Baby Woodrose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Codeine Phosphate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Codeine Phosphate is filed under 6 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates, cns depressants. Hawaiian Baby Woodrose has documented interactions with 1 drug class — the most serious being serotonergic drugs (moderate) — and none of Codeine Phosphate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hawaiian Baby Woodrose Does Interact With Other Medications

Hawaiian Baby Woodrose has 184 moderate known drug interactions in our database — Codeine Phosphate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 184 No known interaction 2,646 (incl. Codeine Phosphate)
Taking anything else?

Check Another of Your Medications Against Hawaiian Baby Woodrose

Covers the 2,830 medications we’ve checked against Hawaiian Baby Woodrose. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hawaiian Baby Woodrose and Codeine Phosphate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on Additional detail

    Hawaiian Baby Woodrose

    “Orally, four homogenized Hawaiian baby woodrose seeds has been reported to cause difficulty expressing thoughts, fits of laughter, and paranoia in one person. The seed has also been reported to cause mood elevation and anxiety. In an 18-year-old male, ingestion of 15 seeds resulted in erratic and bizarre behavior accompanying suicidal and homicidal ideation and depression.”

    Hawaiian Baby Woodrose · Natural Medicines adverse-effect record, reported in anxiety.

    5 sources cited
    1. 103857. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed
    2. 103860. Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62-71. PubMed
    3. 103858. Gertsch JH, Wood C. Case report: an ingestion of Hawaiian Baby Woodrose seeds associated with acute psychosis. Hawaii Med J. 2003 Jun;62(6):127, 129.
    4. 97867. Vigor C, Fabre N, Fourasté I, Moulis C. Neoclerodane diterpenoids from Croton eluteria. J Nat Prod. 2002;65(8):1180-2.
    5. 109536. Sobanski E, Dalm S, Sievers L, et al. Herbal high: substance-induced psychosis after consumption of seeds of the Hawaiian baby woodrose. Z Kinder Jugendpsychiatr Psychother. 2021 Jul;49(4):307-11. PubMed

    Codeine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Codeine Phosphate. Read the label on DailyMed ›

  • Tremor or shakiness Additional detail

    Hawaiian Baby Woodrose

    “Orally, four homogenized Hawaiian baby woodrose seeds have been reported to cause fatigue lasting for 2 hours and tremor of the hands lasting for about 9 hours in one person. Weakness, vertigo, and heaviness in the legs have also been reported. The seeds have also been reported to cause auditory hallucinations and altered visual perception.”

    Hawaiian Baby Woodrose · Natural Medicines adverse-effect record, reported in fatigue.

    5 sources cited
    1. 103857. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed
    2. 5301. Al-Assmar SE. The seeds of the Hawaiian baby woodrose are a powerful hallucinogen. Arch Intern Med 1999;159:2090. PubMed
    3. 103860. Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62-71. PubMed
    4. 5304. Shawcross WE. Recreational use of ergoline alkaloid from Argyreia nervosa. J Psychoactive Drugs 1983;15:251-9.
    5. 97867. Vigor C, Fabre N, Fourasté I, Moulis C. Neoclerodane diterpenoids from Croton eluteria. J Nat Prod. 2002;65(8):1180-2.

    Codeine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Codeine Phosphate. Read the label on DailyMed ›

  • Sweating Additional detail

    Hawaiian Baby Woodrose

    “Hawaiian baby woodrose is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. The number of seeds needed to produce adverse effects differs for each individual.

    Most Common Adverse Effects:

    Orally: Dizziness, fatigue, hallucinations, hypertension, mydriasis, paranoia, sweating, tachycardia.”

    Hawaiian Baby Woodrose · Natural Medicines adverse-effect record, reported in fatigue.

    Codeine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Codeine Phosphate. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Hawaiian Baby Woodrose

    “Orally, approximately four homogenized Hawaiian baby woodrose seeds have been reported to cause temporary blood pressure elevation. In one 18-year-old male, consuming 15 Hawaiian baby woodrose seeds resulted in tachycardia and hypertension. The patient also used cannabis, but symptoms were thought to be related to Hawaiian baby woodrose.”

    Hawaiian Baby Woodrose · Natural Medicines adverse-effect record, reported in hypertension.

    2 sources cited
    1. 103857. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed
    2. 103858. Gertsch JH, Wood C. Case report: an ingestion of Hawaiian Baby Woodrose seeds associated with acute psychosis. Hawaii Med J. 2003 Jun;62(6):127, 129.

    Codeine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Codeine Phosphate. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Hawaiian Baby Woodrose

    Recorded for Hawaiian Baby Woodrose in the same Natural Medicines adverse-effect record shown under Low mood above.

    Codeine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Codeine Phosphate. Read the label on DailyMed ›

  • Tiredness / Dizziness Additional detail

    Hawaiian Baby Woodrose

    Recorded for Hawaiian Baby Woodrose in the same Natural Medicines adverse-effect record shown under Sweating above.

    Codeine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Codeine Phosphate. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Hawaiian Baby Woodrose

    “Orally, four homogenized Hawaiian baby woodrose seeds have been reported to cause nausea and vomiting. The number of seeds needed to produce adverse effects differs for each individual. Additionally, the alkaloid and lysergic acid amide contents vary from batch to batch.”

    Hawaiian Baby Woodrose · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 103857. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed

    Codeine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Codeine Phosphate. Read the label on DailyMed ›

Reported for Hawaiian Baby Woodrose but not commonly for Codeine Phosphate: raised blood pressure, hallucinations and vivid dreams or nightmares.

Effects for Codeine Phosphate come from the ADVERSE REACTIONS section of its FDA label; effects for Hawaiian Baby Woodrose come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 6,086 voluntary FDA FAERS reports for Codeine Phosphate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Hawaiian Baby Woodrose in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Hawaiian Baby Woodrose or Codeine Phosphate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hawaiian Baby Woodrose or Codeine Phosphate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Codeine Phosphate

This page covers Hawaiian Baby Woodrose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Codeine Phosphate page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 114 moderate · 23 minor.

From our pharmacist’s overview on the Codeine Phosphate page

“Codeine phosphate is an opioid painkiller and cough suppressant that slows breathing along with brain activity, and the wrong supplement can push that effect into dangerous territory. Seven of the 144 documented ingredients rate major, and nearly all of that serious risk comes from things that deepen sedation.”

Reviewed by 2 · Jul 18, 2026

Open the Codeine Phosphate interaction page

How much people look this up

Where Hawaiian Baby Woodrose and Codeine Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hawaiian Baby Woodrose
Steady interest

#1,022 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Codeine Phosphate
Top 25%

#342 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hawaiian Baby Woodrose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hawaiian Baby Woodrose and Codeine Phosphate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hawaiian Baby Woodrose

What is Hawaiian Baby Woodrose?

Hawaiian Baby Woodrose
  • Hallucinogenic/psychedelic effects (recreational)
  • Pain relief (traditional)
  • Anti-inflammatory (traditional)
  • Aphrodisiac (traditional Ayurvedic use)
  • Nervous system tonic (traditional)

Hawaiian Baby Woodrose seeds contain LSD-like compounds and are most often used recreationally to cause hallucinations, not as a safe or proven medicine. Because of serious safety risks, unpredictable effects, and unclear legal status, it is generally not recommended. If you are considering any product containing it, talk to a pharmacist or doctor first.

Argyreia nervosa · Convolvulaceae · Seeds (mainly), also roots and leaves in traditional use · Whole seeds, ground seed powder, seed extracts; sometimes sold as ornamental seeds

An interaction check asks whether these two react with each other — it does not ask whether Hawaiian Baby Woodrose is a good idea for someone in your situation. Here is what our Hawaiian Baby Woodrose record says about it on its own.

Hawaiian Baby Woodrose: dosing

There is no established safe or medical dose for Hawaiian Baby Woodrose, and because the strength of the seeds varies, no dose can be considered reliable or safe. The safest choice for most people is to avoid it entirely.

From our Hawaiian Baby Woodrose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hawaiian Baby Woodrose monograph & all interactions
Medication

About Codeine

What Is Codeine Used For?

Brand name: Codeine

Codeine Sulfate tablets are used for the management of mild to moderate pain in adults and adolescents when other treatments have not worked well enough or are not tolerated. It is an opioid medication, so it is only appropriate when non-opioid options are inadequate.

Because of its serious risks — including addiction, misuse, and overdose — codeine is reserved for patients who truly need an opioid. Prescribers are expected to use the lowest effective dose for the shortest time possible.

Most-Reported Side Effects for Codeine Phosphate

From FAERS, the FDA’s public side-effect reporting system (6,086 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dependence 3,533 reports
Overdose 730 reports
Back pain 471 reports
Back injury 240 reports
Arthralgia 173 reports
See full Codeine drug information
Keep checking

Other Drugs & Hawaiian Baby Woodrose

Browse every other medication we’ve checked against Hawaiian Baby Woodrose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
184Moderate
0Minor
2,645No known interaction
184 Moderate 2,645 No interaction
Moderate

184 interactions

Showing 60 of 184 moderate interactions — see all 184 on the Hawaiian Baby Woodrose page.

No interaction 2,645 drugs checked — show the list

We also checked Hawaiian Baby Woodrose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,645 medications checked with no known interaction — see the full Hawaiian Baby Woodrose list.

See the full Hawaiian Baby Woodrose interactions page
See every supplement checked against Codeine Phosphate, ranked by severity
Evidence & sources

Hawaiian Baby Woodrose References

The 9 references that drive our Hawaiian Baby Woodrose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Al-Assmar SE. The seeds of the Hawaiian baby woodrose are a powerful hallucinogen. Arch Intern Med 1999;159:2090. PubMed
  3. Shawcross WE. Recreational use of ergoline alkaloid from Argyreia nervosa. J Psychoactive Drugs 1983;15:251-9.
  4. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  5. Vigor C, Fabre N, Fourasté I, Moulis C. Neoclerodane diterpenoids from Croton eluteria. J Nat Prod. 2002;65(8):1180-2.
  6. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed
  7. Gertsch JH, Wood C. Case report: an ingestion of Hawaiian Baby Woodrose seeds associated with acute psychosis. Hawaii Med J. 2003 Jun;62(6):127, 129.
  8. Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62-71. PubMed
  9. Sobanski E, Dalm S, Sievers L, et al. Herbal high: substance-induced psychosis after consumption of seeds of the Hawaiian baby woodrose. Z Kinder Jugendpsychiatr Psychother. 2021 Jul;49(4):307-11. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hawaiian Baby Woodrose and Codeine Phosphate Together: Common Questions

Is it safe to take Hawaiian Baby Woodrose with Codeine Phosphate?
We do not list a known interaction between Hawaiian Baby Woodrose and Codeine Phosphate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hawaiian Baby Woodrose and Codeine Phosphate have any of the same side effects?
Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Hawaiian Baby Woodrose and Codeine Phosphate combination checked?
Interactions in our licensed database are recorded against drug classes. Codeine Phosphate is filed under 6 classifications, and Hawaiian Baby Woodrose has documented interactions with 1 drug class — none of Codeine Phosphate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hawaiian Baby Woodrose interact with any other medications?
Yes. Hawaiian Baby Woodrose has 184 documented drug interactions in our database — Codeine Phosphate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Codeine Phosphate interact with any supplements?
Yes. Codeine Phosphate has documented interactions with 144 supplements in our database — Hawaiian Baby Woodrose is not one of them. The Codeine Phosphate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hawaiian Baby Woodrose monograph Uses, safety profile, and every drug interaction in one place Codeine drug information The full plain-English guide to this medication Codeine Phosphate supplement interactions Every supplement checked against Codeine Phosphate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Codeine Phosphate and Hawaiian Baby Woodrose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.