Drug & supplement interaction

Hawaiian Baby Woodrose + Sofosbuvir

Sofosbuvir brand name: Sovaldi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Hawaiian Baby Woodrose and Sofosbuvir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hawaiian Baby Woodrose and Sofosbuvir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sofosbuvir and Hawaiian Baby Woodrose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hawaiian Baby Woodrose safety at a glance

Hawaiian Baby Wood... overall Avoid Seeds contain LSD-like compounds and can cause serious psychological and physical effects.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sofosbuvir and Hawaiian Baby Woodrose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sofosbuvir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sofosbuvir is filed under 4 classifications — including p-glycoprotein substrates, oral drugs. Hawaiian Baby Woodrose has documented interactions with 1 drug class — the most serious being serotonergic drugs (moderate) — and none of Sofosbuvir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hawaiian Baby Woodrose Does Interact With Other Medications

Hawaiian Baby Woodrose has 184 moderate known drug interactions in our database — Sofosbuvir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 184 No known interaction 2,646 (incl. Sofosbuvir)
Taking anything else?

Check Another of Your Medications Against Hawaiian Baby Woodrose

Covers the 2,830 medications we’ve checked against Hawaiian Baby Woodrose. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hawaiian Baby Woodrose and Sofosbuvir May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tiredness reported in 17.7% of FDA reports for Sofosbuvir Additional detail

    Hawaiian Baby Woodrose

    “Orally, four homogenized Hawaiian baby woodrose seeds have been reported to cause fatigue lasting for 2 hours and tremor of the hands lasting for about 9 hours in one person. Weakness, vertigo, and heaviness in the legs have also been reported. The seeds have also been reported to cause auditory hallucinations and altered visual perception.”

    Hawaiian Baby Woodrose · Natural Medicines adverse-effect record, reported in fatigue.

    5 sources cited
    1. 103857. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed
    2. 5301. Al-Assmar SE. The seeds of the Hawaiian baby woodrose are a powerful hallucinogen. Arch Intern Med 1999;159:2090. PubMed
    3. 103860. Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62-71. PubMed
    4. 5304. Shawcross WE. Recreational use of ergoline alkaloid from Argyreia nervosa. J Psychoactive Drugs 1983;15:251-9.
    5. 97867. Vigor C, Fabre N, Fourasté I, Moulis C. Neoclerodane diterpenoids from Croton eluteria. J Nat Prod. 2002;65(8):1180-2.

    Sofosbuvir

    Listed in the ADVERSE REACTIONS section of the FDA label for Sofosbuvir, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea reported in 7.5% of FDA reports for Sofosbuvir Additional detail

    Hawaiian Baby Woodrose

    “Orally, four homogenized Hawaiian baby woodrose seeds have been reported to cause nausea and vomiting. The number of seeds needed to produce adverse effects differs for each individual. Additionally, the alkaloid and lysergic acid amide contents vary from batch to batch.”

    Hawaiian Baby Woodrose · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 103857. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed

    Sofosbuvir

    Listed in the ADVERSE REACTIONS section of the FDA label for Sofosbuvir, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Hawaiian Baby Woodrose but not commonly for Sofosbuvir: raised blood pressure, hallucinations, a fast or pounding heartbeat and vivid dreams or nightmares.

Effects for Sofosbuvir come from the ADVERSE REACTIONS section of its FDA label; effects for Hawaiian Baby Woodrose come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 52,253 voluntary FDA FAERS reports for Sofosbuvir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Hawaiian Baby Woodrose in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Sofosbuvir

This page covers Hawaiian Baby Woodrose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 37 moderate · 16 minor.

From our pharmacist’s overview on the Sofosbuvir page

“Sofosbuvir (Sovaldi) cures hepatitis C over a fixed course, so a supplement that lowers its blood level risks more than a side effect; it can let the virus survive treatment. The two major-rated interactions among the 55 ingredients here do exactly that: St.”

Reviewed by 2 · Jul 18, 2026

Open the Sofosbuvir interaction page

How much people look this up

Where Hawaiian Baby Woodrose and Sofosbuvir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hawaiian Baby Woodrose
Steady interest

#1,418 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sofosbuvir
Steady interest

#2,096 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hawaiian Baby Woodrose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Hawaiian Baby Woodrose and Sofosbuvir records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hawaiian Baby Woodrose

What is Hawaiian Baby Woodrose?

Hawaiian Baby Woodrose
  • Hallucinogenic/psychedelic effects (recreational)
  • Pain relief (traditional)
  • Anti-inflammatory (traditional)
  • Aphrodisiac (traditional Ayurvedic use)
  • Nervous system tonic (traditional)

Hawaiian Baby Woodrose seeds contain LSD-like compounds and are most often used recreationally to cause hallucinations, not as a safe or proven medicine. Because of serious safety risks, unpredictable effects, and unclear legal status, it is generally not recommended. If you are considering any product containing it, talk to a pharmacist or doctor first.

Argyreia nervosa · Convolvulaceae · Seeds (mainly), also roots and leaves in traditional use · Whole seeds, ground seed powder, seed extracts; sometimes sold as ornamental seeds

An interaction check asks whether these two react with each other — it does not ask whether Hawaiian Baby Woodrose is a good idea for someone in your situation. Here is what our Hawaiian Baby Woodrose record says about it on its own.

Hawaiian Baby Woodrose: dosing

There is no established safe or medical dose for Hawaiian Baby Woodrose, and because the strength of the seeds varies, no dose can be considered reliable or safe. The safest choice for most people is to avoid it entirely.

From our Hawaiian Baby Woodrose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hawaiian Baby Woodrose monograph & all interactions
Medication

About Sofosbuvir

What Is Sofosbuvir Used For?

Brand name: Sovaldi

Sovaldi (sofosbuvir) is used to treat chronic hepatitis C virus (HCV) infection. In adults, it treats genotype 1, 2, 3, or 4 HCV — with or without compensated cirrhosis (mild liver scarring that the liver is still managing). It is always used as part of a combination regimen with other antiviral medicines.

In children 3 years and older, Sovaldi is approved for genotype 2 or 3 HCV, with or without compensated cirrhosis, in combination with ribavirin. Sovaldi is also used with ribavirin in adults with HCV-related liver cancer (hepatocellular carcinoma) who are waiting for a liver transplant, to help prevent HCV from returning after transplant.

Most-Reported Side Effects for Sofosbuvir

From FAERS, the FDA’s public side-effect reporting system (52,335 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 9,258 reports
Headache 7,696 reports
Nausea 3,911 reports
Hepatitis c 3,047 reports
Insomnia 2,435 reports
See full Sofosbuvir drug information
Keep checking

Other Drugs & Hawaiian Baby Woodrose

Browse every other medication we’ve checked against Hawaiian Baby Woodrose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
184Moderate
0Minor
2,645No known interaction
184 Moderate 2,645 No interaction
Moderate

184 interactions

Showing 60 of 184 moderate interactions — see all 184 on the Hawaiian Baby Woodrose page.

No interaction 2,645 drugs checked — show the list

We also checked Hawaiian Baby Woodrose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,645 medications checked with no known interaction — see the full Hawaiian Baby Woodrose list.

See the full Hawaiian Baby Woodrose interactions page
See every supplement checked against Sofosbuvir, ranked by severity
Evidence & sources

Hawaiian Baby Woodrose References

The 9 references that drive our Hawaiian Baby Woodrose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Al-Assmar SE. The seeds of the Hawaiian baby woodrose are a powerful hallucinogen. Arch Intern Med 1999;159:2090. PubMed
  3. Shawcross WE. Recreational use of ergoline alkaloid from Argyreia nervosa. J Psychoactive Drugs 1983;15:251-9.
  4. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  5. Vigor C, Fabre N, Fourasté I, Moulis C. Neoclerodane diterpenoids from Croton eluteria. J Nat Prod. 2002;65(8):1180-2.
  6. Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int. 2012;214(1-3):e6-8. PubMed
  7. Gertsch JH, Wood C. Case report: an ingestion of Hawaiian Baby Woodrose seeds associated with acute psychosis. Hawaii Med J. 2003 Jun;62(6):127, 129.
  8. Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62-71. PubMed
  9. Sobanski E, Dalm S, Sievers L, et al. Herbal high: substance-induced psychosis after consumption of seeds of the Hawaiian baby woodrose. Z Kinder Jugendpsychiatr Psychother. 2021 Jul;49(4):307-11. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hawaiian Baby Woodrose and Sofosbuvir Together: Common Questions

Is it safe to take Hawaiian Baby Woodrose with Sofosbuvir?
We do not list a known interaction between Hawaiian Baby Woodrose and Sofosbuvir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hawaiian Baby Woodrose and Sofosbuvir have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Hawaiian Baby Woodrose and Sofosbuvir combination checked?
Interactions in our licensed database are recorded against drug classes. Sofosbuvir is filed under 4 classifications, and Hawaiian Baby Woodrose has documented interactions with 1 drug class — none of Sofosbuvir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hawaiian Baby Woodrose interact with any other medications?
Yes. Hawaiian Baby Woodrose has 184 documented drug interactions in our database — Sofosbuvir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sofosbuvir interact with any supplements?
Yes. Sofosbuvir has documented interactions with 55 supplements in our database — Hawaiian Baby Woodrose is not one of them. The Sofosbuvir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hawaiian Baby Woodrose monograph Uses, safety profile, and every drug interaction in one place Sofosbuvir drug information The full plain-English guide to this medication Sofosbuvir supplement interactions Every supplement checked against Sofosbuvir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sofosbuvir and Hawaiian Baby Woodrose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.