We found no known interaction between Hemlock and Gadoterate Meglumine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Gadoterate Meglumine and Hemlock in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Hemlock at all — not against Gadoterate Meglumine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Hemlock safety at a glance
Hemlock overall
AvoidHemlock is a deadly poison and should never be taken in any amount.
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
No Interaction Found — But Data Suggests Hemlock and Gadoterate Meglumine May Share Several of the Same Side Effects
This is not an interaction. Neither one changes how your body handles the other, and
nothing here says they react together. What our sources do show is that each has
separately been linked to the effects below — so taking both can make those effects
more likely to turn up, and harder to pin on one or the other if they do.
4 of them are
worth acting on rather than waiting out — marked below.
A slow heartbeatWorth acting onAdditional detail
Hemlock
“Hemlock is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, hemlock can cause burning of the mouth, throat, and abdomen, nausea, vomiting, excessive urination, salivation, drowsiness, mydriasis, muscle pain, rapid muscle swelling and stiffness, rhabdomyolysis, and tachycardia followed by bradycardia.”
Hemlock · Natural Medicines adverse-effect record, reported in muscle breakdown.
6 sources cited
6340.Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed ↗
6341.Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
54709.Biberci, E., Altuntas, Y., Cobanoglu, A., and Alpinar, A. Acute respiratory arrest following hemlock (Conium maculatum) intoxication. J.Toxicol.Clin.Toxicol. 2002;40(4):517-518.
54711.Foster, P. F., McFadden, R., Trevino, R., Galliardt, S., Kopczewski, L. A., Gugliuzza, K., Gonzalez, Z., and Wright, F. Successful transplantation of donor organs from a hemlock poisoning victim. Transplantation 9-15-2003;76(5):874-876. PubMed ↗
54716.Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed ↗
“Orally, hemlock can cause tachycardia followed by bradycardia, cardiovascular collapse, and death. In one case report, a 6-year old girl had prolonged coagulation tests after accidental ingestion of hemlock. It can also cause hypertension.
Intravenously, hemlock resulted in a brief cardiac arrest followed by return of spontaneous circulation in one case report.”
Hemlock · Natural Medicines adverse-effect record, reported in cardiac arrest.
6 sources cited
6340.Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed ↗
6341.Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
96877.Konca C, Kahramaner Z, Bosnak M, Kocamaz H. Hemlock (Conium Maculatum) poisoning in a child. Turk J Emerg Med. 2016;14(1):34-6. DOI ↗
110410.Boskabadi J, Askari Z, Zakariaei Z, Fakhar M, Tabaripour R. Mild-to-severe poisoning due to Conium maculatum as toxic herb: A case series. Clin Case Rep. 2021 Jul 23;9(7):e04509.
96876.Brtalik D, Stopyra J, Hannum J. Intravenous poison hemlock injection resulting in prolonged respiratory failure and encephalopathy. J Med Toxicol. 2017;13(2):180-182. PubMed ↗
“Orally, hemlock can cause drowsiness, fatigue, lethargy, dizziness, numbness, loss of speech, tremors, paralysis, seizures, encephalopathy, unconsciousness, and death. Death from hemlock toxicity is usually due to respiratory paralysis.
A case report describes prolonged status epilepticus in a 41-year-old, previously healthy female who mistook hemlock root for parsnip.”
Hemlock · Natural Medicines adverse-effect record, reported in epilepsy.
6 sources cited
6340.Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed ↗
6341.Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
10778.Carod-Artal FJ. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Rev Neurol 2003;36:860-71.
54711.Foster, P. F., McFadden, R., Trevino, R., Galliardt, S., Kopczewski, L. A., Gugliuzza, K., Gonzalez, Z., and Wright, F. Successful transplantation of donor organs from a hemlock poisoning victim. Transplantation 9-15-2003;76(5):874-876. PubMed ↗
54716.Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed ↗
“Orally, hemlock has been reported to cause myoglobinuria, acute tubular necrosis, and acute renal failure. Plasma exchange effectively improved the signs of renal failure in one case of hemlock poisoning.”
Hemlock · Natural Medicines adverse-effect record, reported in poisoning.
5 sources cited
54716.Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed ↗
54717.Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Bruno, S., Scatizzi, A., and De Marco, S. Rhabdomyolysis and acute tubular necrosis in coniine (hemlock) poisoning. Lancet 12-16-1989;2(8677):1461-1462. PubMed ↗
54718.Rizzi, D., Introna, F., Jr., Gagliano, Candela R., Di Nunno, C., Ricco, R., Recchia, R., and De, Michele, V. [Toxic rhabdomyolysis and tubular necrosis in hemlock poisoning. 4 case reports]. Clin.Ter. 2-15-1988;124(3):193-201.
54728.Scatizzi, A., Di Maggio, A., Rizzi, D., Sebastio, A. M., and Basile, C. Acute renal failure due to tubular necrosis caused by wildfowl-mediated hemlock poisoning. Ren Fail. 1993;15(1):93-96. PubMed ↗
54727.Montemurro, N. E., Di Maggio, A., Strippoli, P., Coviello, F., Godino, F., Miloro, G., and Scatizzi, A. Combined dialysis and plasma-exchange in acute renal failure. Biomater.Artif.Cells Immobilization Biotechnol. 1993;21(2):283-287. PubMed ↗
Drowsiness / Vomitingreported in 11.5% of FDA reports for Gadoterate MeglumineAdditional detail
Hemlock
Recorded for Hemlock in the same Natural Medicines adverse-effect record shown under A slow heartbeat above.
Gadoterate Meglumine
Listed in the ADVERSE REACTIONS section of the FDA label for Gadoterate Meglumine, and in voluntary FDA adverse-event reports.
Read the label on DailyMed ›
Nauseareported in 14.3% of FDA reports for Gadoterate MeglumineAdditional detail
Hemlock
“Orally, hemlock causes burning of the mouth, throat, and abdomen. It can also cause nausea, vomiting, and increased salivation.”
Hemlock · Natural Medicines adverse-effect record, reported in nausea and vomiting.
5 sources cited
6341.Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
96877.Konca C, Kahramaner Z, Bosnak M, Kocamaz H. Hemlock (Conium Maculatum) poisoning in a child. Turk J Emerg Med. 2016;14(1):34-6. DOI ↗
96878.Chen HY, Horng H, Rowley F, Smollin C. Rapid respiratory arrest after ingestion of poison hemlock mistaken for wild celery. Clin Toxicol (Phila). 2017;55(2):155-156. PubMed ↗
110410.Boskabadi J, Askari Z, Zakariaei Z, Fakhar M, Tabaripour R. Mild-to-severe poisoning due to Conium maculatum as toxic herb: A case series. Clin Case Rep. 2021 Jul 23;9(7):e04509.
Gadoterate Meglumine
Listed in the ADVERSE REACTIONS section of the FDA label for Gadoterate Meglumine, and in voluntary FDA adverse-event reports.
Read the label on DailyMed ›
SwellingAdditional detail
Hemlock
“Orally, hemlock can cause muscle pain, rapid muscle swelling and stiffness, and rhabdomyolysis. Plasma exchange effectively improved the signs of rhabdomyolysis in one case of hemlock poisoning.”
Hemlock · Natural Medicines adverse-effect record, reported in muscle breakdown.
5 sources cited
6340.Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed ↗
6341.Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
110410.Boskabadi J, Askari Z, Zakariaei Z, Fakhar M, Tabaripour R. Mild-to-severe poisoning due to Conium maculatum as toxic herb: A case series. Clin Case Rep. 2021 Jul 23;9(7):e04509.
54727.Montemurro, N. E., Di Maggio, A., Strippoli, P., Coviello, F., Godino, F., Miloro, G., and Scatizzi, A. Combined dialysis and plasma-exchange in acute renal failure. Biomater.Artif.Cells Immobilization Biotechnol. 1993;21(2):283-287. PubMed ↗
Showing the 10 most notable of 12 shared effects — ranked by how unusual each one is, not just whether both lists mention it.
Reported for Hemlock but not commonly for Gadoterate Meglumine: severe muscle breakdown and muscle pain.
Effects for Gadoterate Meglumine come from the ADVERSE REACTIONS section of its FDA label; effects for
Hemlock come from the Natural Medicines adverse-effect record, quoted above.
Where a percentage is shown, it is the share of 3,653 voluntary FDA FAERS reports for Gadoterate Meglumine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.
🤰Special populations
Hemlock in Pregnancy & Breastfeeding
Pregnancy And LactationUnsafe
When used orally because ingestion can be lethal; avoid using.
Taking Hemlock as Part of a Dietary Supplement Product? Check It for Interactions
We hold 9 real supplement products containing Hemlock, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hemlock. Even though Hemlock itself has no known interaction with Gadoterate Meglumine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
AI product search
How much people look this up
Where Hemlock and Gadoterate Meglumine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
SupplementHemlock
Steady interest
#951 of 1,452
supplements looked up here in the last 7 days
29 days agotoday
MedicationGadoterate Meglumine
Top 10%
#279 of 2,830
medications looked up here in the last 7 days
29 days agotoday
Position among everything looked up on this site, not a measure of how commonly either one is
used or how important it is. A supplement can climb this list because of a news story.
It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hemlock and Gadoterate Meglumine records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Hemlock (Conium maculatum) is a highly poisonous plant that has no safe or proven medicinal use today. Even small amounts can cause paralysis and death, so it should never be consumed or applied to the body. Do not use hemlock or any product containing it.
Conium maculatum · Apiaceae · Whole plant, including leaves, seeds, stems, and roots (all parts are poisonous) · Not safely used in any form; historically prepared as extracts, tinctures, or poultices
An interaction check asks whether these two react with each other — it does not ask whether Hemlock is a good idea for someone in your situation. Here is what our Hemlock record says about it on its own.
Hemlock: dosing
There is no safe dose of hemlock. It is not a supplement and should never be measured out or taken. Even a small amount of plant material or seeds can be fatal to humans and animals.Do not buy, prepare, or consume any product that contains Conium maculatum.
From our Hemlock monograph — the full record covers uses, side effects and every documented interaction.
Most-Reported Side Effects for Gadoterate Meglumine
From FAERS, the FDA’s public side-effect reporting system (3,653 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Urticaria648 reports
Dyspnea546 reports
Nausea523 reports
Pruritus479 reports
Erythema422 reports
Keep checking
Other Drugs & Hemlock
Browse every other medication we’ve checked against Hemlock — both the ones with a known interaction and the ones without. Select any drug for the full detail.
The 18 references that drive our Hemlock monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
Lopez TA, Cid MS, Bianchini ML. Biochemistry of hemlock (Conium maculatum L.) alkaloids and their acute and chronic toxicity in livestock. A review. Toxicon 1999;37:841-65. PubMed ↗
Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed ↗
Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
Carod-Artal FJ. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Rev Neurol 2003;36:860-71.
Biberci, E., Altuntas, Y., Cobanoglu, A., and Alpinar, A. Acute respiratory arrest following hemlock (Conium maculatum) intoxication. J.Toxicol.Clin.Toxicol. 2002;40(4):517-518.
Foster, P. F., McFadden, R., Trevino, R., Galliardt, S., Kopczewski, L. A., Gugliuzza, K., Gonzalez, Z., and Wright, F. Successful transplantation of donor organs from a hemlock poisoning victim. Transplantation 9-15-2003;76(5):874-876. PubMed ↗
Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed ↗
Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Bruno, S., Scatizzi, A., and De Marco, S. Rhabdomyolysis and acute tubular necrosis in coniine (hemlock) poisoning. Lancet 12-16-1989;2(8677):1461-1462. PubMed ↗
Rizzi, D., Introna, F., Jr., Gagliano, Candela R., Di Nunno, C., Ricco, R., Recchia, R., and De, Michele, V. [Toxic rhabdomyolysis and tubular necrosis in hemlock poisoning. 4 case reports]. Clin.Ter. 2-15-1988;124(3):193-201.
Montemurro, N. E., Di Maggio, A., Strippoli, P., Coviello, F., Godino, F., Miloro, G., and Scatizzi, A. Combined dialysis and plasma-exchange in acute renal failure. Biomater.Artif.Cells Immobilization Biotechnol. 1993;21(2):283-287. PubMed ↗
Scatizzi, A., Di Maggio, A., Rizzi, D., Sebastio, A. M., and Basile, C. Acute renal failure due to tubular necrosis caused by wildfowl-mediated hemlock poisoning. Ren Fail. 1993;15(1):93-96. PubMed ↗
Brtalik D, Stopyra J, Hannum J. Intravenous poison hemlock injection resulting in prolonged respiratory failure and encephalopathy. J Med Toxicol. 2017;13(2):180-182. PubMed ↗
Konca C, Kahramaner Z, Bosnak M, Kocamaz H. Hemlock (Conium Maculatum) poisoning in a child. Turk J Emerg Med. 2016;14(1):34-6. DOI ↗
Chen HY, Horng H, Rowley F, Smollin C. Rapid respiratory arrest after ingestion of poison hemlock mistaken for wild celery. Clin Toxicol (Phila). 2017;55(2):155-156. PubMed ↗
Hove KD, Brøns C, Færch K, Lund SS, Rossing P, Vaag A. Effects of 12 weeks of treatment with fermented milk on blood pressure, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind placebo-contro
Boskabadi J, Askari Z, Zakariaei Z, Fakhar M, Tabaripour R. Mild-to-severe poisoning due to Conium maculatum as toxic herb: A case series. Clin Case Rep. 2021 Jul 23;9(7):e04509.
Parreira S, Antunes AP, Bento H, Moniz I. A hemlock salad: a case report of super-refractory status epilepticus after accidental hemlock ingestion. Neurol Sci. 2021 Oct;42(10):4335-9. PubMed ↗
Taking Hemlock and Gadoterate Meglumine Together: Common Questions
Is it safe to take Hemlock with Gadoterate Meglumine?
We do not list a known interaction between Hemlock and Gadoterate Meglumine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hemlock and Gadoterate Meglumine have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Related Supplements & Herbs
Browse interactions for other vitamins, herbs, and supplements.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
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