Drug & supplement interaction

Holly + Teprotumumab-Trbw

Teprotumumab-Trbw brand name: Tepezza.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Holly and Teprotumumab-Trbw in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Holly and Teprotumumab-Trbw

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Teprotumumab-Trbw and Holly in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Holly at all — not against Teprotumumab-Trbw, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Holly safety at a glance

Holly overall Use caution The berries are toxic if eaten, and there is little safety data on leaf preparations.

Pregnancy Unsafe When berries are ingested. There is insufficient reliable information available about the safety of holly leaves; avoid using. Read the full pregnancy detail

Breastfeeding Unsafe When berries are ingested. There is insufficient reliable information available about the safety of holly leaves; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Teprotumumab-Trbw and Holly? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Holly Itself Has Been Linked To

This is not an interaction — nothing below involves Teprotumumab-Trbw. It is the side-effect record for Holly on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Holly, this list is the first place to look.

Diarrhea / Vomiting / Nausea Additional detail
“Orally, ingestion of holly leaf can cause GI irritation, diarrhea, nausea, and vomiting (6,18). Holly leaf spines may tear or puncture skin or mucous membranes (6). Ingestion of as few as 2 holly berries can cause vomiting and diarrhea in small children (6). Ingestion of more than 5 holly berries can cause nausea, vomiting, and diarrhea (6,18). Ingestion of 20-30 holly berries can cause death (18).”

Holly · Natural Medicines adverse-effect record, reported in diarrhea.
2 sources cited

6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
“Orally, ingestion of holly leaf can cause GI irritation, diarrhea, nausea, and vomiting (6,18). Holly leaf spines may tear or puncture skin or mucous membranes (6). Ingestion of as few as 2 holly berries can cause vomiting and diarrhea in small children (6). Ingestion of more than 5 holly berries can cause nausea, vomiting, and diarrhea (6,18).”

Holly · Natural Medicines adverse-effect record, reported in diarrhea.
2 sources cited

6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Holly — expand a row for the licensed statement it rests on. We haven’t matched Teprotumumab-Trbw to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Teprotumumab-Trbw.

Special populations

Holly in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When berries are ingested. There is insufficient reliable information available about the safety of holly leaves; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

One more smart check

Taking Holly as Part of a Dietary Supplement Product? Check It for Interactions

We hold 11 real supplement products containing Holly, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Holly. Even though Holly itself has no known interaction with Teprotumumab-Trbw, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Holly and Teprotumumab-Trbw Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Holly

Steady interest

#1,320 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Teprotumumab-Trbw

Steady interest

#2,513 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Holly reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Holly and Teprotumumab-Trbw records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Holly

What is Holly?

Fever
Cough and chest congestion
Joint pain (traditional use)
Digestive complaints
Mild diuretic

Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable human evidence supporting any health benefit of holly leaves, and because of safety concerns it is generally best avoided as a supplement unless guided by a knowledgeable healthcare professional.

Ilex aquifolium · Aquifoliaceae · Leaves and berries (and bark in some traditions) · Dried leaf tea, tinctures, and homeopathic preparations; berries are not used as a supplement

An interaction check asks whether these two react with each other — it does not ask whether Holly is a good idea for someone in your situation. Here is what our Holly record says about it on its own.

Holly: dosing

There is no established or standardized dose for holly, because it has not been properly studied as a medicine. We cannot provide a safe recommended amount.If you choose to use a commercial holly product despite the limited evidence, follow the directions on the label exactly and never exceed them.

From our Holly monograph — the full record covers uses, side effects and every documented interaction.

Read the full Holly monograph & all interactions

Medication

About Teprotumumab-trbw Injection

What Is Teprotumumab-trbw Injection Used For?

Brand name: Tepezza

Teprotumumab-trbw injection is used to treat thyroid eye disease (TED; Graves' eye disease; a disorder in which the immune system causes inflammation and swelling behind the eye). Teprotumumab-trbw is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain protein in the body that causes inflammation in the eye.

See full Teprotumumab-trbw Injection drug information

Keep checking

Other Drugs & Holly

Browse every other medication we’ve checked against Holly — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Holly against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Holly list.

See the full Holly interactions page

See every supplement checked against Teprotumumab-Trbw, ranked by severity

Evidence & sources

Holly References

The 2 references that drive our Holly monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Holly and Teprotumumab-Trbw Together: Common Questions

Is it safe to take Holly with Teprotumumab-Trbw?

We do not list a known interaction between Holly and Teprotumumab-Trbw. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Holly monograph Uses, safety profile, and every drug interaction in one place Teprotumumab-trbw Injection drug information The full plain-English guide to this medication Teprotumumab-Trbw supplement interactions Every supplement checked against Teprotumumab-Trbw, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Teprotumumab-Trbw and Holly?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.